Biosynthesis of heme O in intraerythrocytic stages of Plasmodium falciparum and potential inhibitors of this pathway

A number of antimalarial drugs interfere with the electron transport chain and heme-related reactions; however, the biosynthesis of heme derivatives in Plasmodium parasites has not been fully elucidated. Here, we characterized the steps that lead to the farnesylation of heme. After the identificatio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Simão-Gurge, Raquel M., Wunderlich, Gerhard, Cricco, Julia Alejandra, Galindo Cubillos, Eliana F., Domenech-Carbó, Antonio, Cebrián-Torrejón, Gerardo, Almeida, Fernando G., Cirulli, Brenda Analía, Katzin, Alejandro M.
Formato:	article artículo publishedVersion
Lenguaje:	Inglés
Publicado:	Springer Nature 2020
Materias:	Antimalarial drugs Plasmodium parasites Heme O synthesis Plasmodium Falciparum Inhibitors
Acceso en línea:	http://hdl.handle.net/2133/18326 http://hdl.handle.net/2133/18326
Aporte de:	Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario

id	I15-R121-2133-18326
record_format	dspace
institution	Universidad Nacional de Rosario
institution_str	I-15
repository_str	R-121
collection	Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language	Inglés
orig_language_str_mv	eng
topic	Antimalarial drugs Plasmodium parasites Heme O synthesis Plasmodium Falciparum Inhibitors
spellingShingle	Antimalarial drugs Plasmodium parasites Heme O synthesis Plasmodium Falciparum Inhibitors Simão-Gurge, Raquel M. Wunderlich, Gerhard Cricco, Julia Alejandra Galindo Cubillos, Eliana F. Domenech-Carbó, Antonio Cebrián-Torrejón, Gerardo Almeida, Fernando G. Cirulli, Brenda Analía Katzin, Alejandro M. Biosynthesis of heme O in intraerythrocytic stages of Plasmodium falciparum and potential inhibitors of this pathway
topic_facet	Antimalarial drugs Plasmodium parasites Heme O synthesis Plasmodium Falciparum Inhibitors
description	A number of antimalarial drugs interfere with the electron transport chain and heme-related reactions; however, the biosynthesis of heme derivatives in Plasmodium parasites has not been fully elucidated. Here, we characterized the steps that lead to the farnesylation of heme. After the identification of a gene encoding heme O synthase, we identified heme O synthesis in blood stage parasites through the incorporation of radioactive precursors. The presence of heme O synthesis in intraerythrocytic stages of Plasmodium falciparum was confirmed by mass spectrometry. Inabenfide and uniconazole–P appeared to interfere in heme synthesis, accordingly, parasite growth was also affected by the addition of these drugs. We conclude that heme O synthesis occurs in blood stage-P. falciparum and this pathway could be a potential target for antimalarial drugs.
format	article artículo publishedVersion
author	Simão-Gurge, Raquel M. Wunderlich, Gerhard Cricco, Julia Alejandra Galindo Cubillos, Eliana F. Domenech-Carbó, Antonio Cebrián-Torrejón, Gerardo Almeida, Fernando G. Cirulli, Brenda Analía Katzin, Alejandro M.
author_facet	Simão-Gurge, Raquel M. Wunderlich, Gerhard Cricco, Julia Alejandra Galindo Cubillos, Eliana F. Domenech-Carbó, Antonio Cebrián-Torrejón, Gerardo Almeida, Fernando G. Cirulli, Brenda Analía Katzin, Alejandro M.
author_sort	Simão-Gurge, Raquel M.
title	Biosynthesis of heme O in intraerythrocytic stages of Plasmodium falciparum and potential inhibitors of this pathway
title_short	Biosynthesis of heme O in intraerythrocytic stages of Plasmodium falciparum and potential inhibitors of this pathway
title_full	Biosynthesis of heme O in intraerythrocytic stages of Plasmodium falciparum and potential inhibitors of this pathway
title_fullStr	Biosynthesis of heme O in intraerythrocytic stages of Plasmodium falciparum and potential inhibitors of this pathway
title_full_unstemmed	Biosynthesis of heme O in intraerythrocytic stages of Plasmodium falciparum and potential inhibitors of this pathway
title_sort	biosynthesis of heme o in intraerythrocytic stages of plasmodium falciparum and potential inhibitors of this pathway
publisher	Springer Nature
publishDate	2020
url	http://hdl.handle.net/2133/18326 http://hdl.handle.net/2133/18326
work_keys_str_mv	AT simaogurgeraquelm biosynthesisofhemeoinintraerythrocyticstagesofplasmodiumfalciparumandpotentialinhibitorsofthispathway AT wunderlichgerhard biosynthesisofhemeoinintraerythrocyticstagesofplasmodiumfalciparumandpotentialinhibitorsofthispathway AT criccojuliaalejandra biosynthesisofhemeoinintraerythrocyticstagesofplasmodiumfalciparumandpotentialinhibitorsofthispathway AT galindocubilloselianaf biosynthesisofhemeoinintraerythrocyticstagesofplasmodiumfalciparumandpotentialinhibitorsofthispathway AT domenechcarboantonio biosynthesisofhemeoinintraerythrocyticstagesofplasmodiumfalciparumandpotentialinhibitorsofthispathway AT cebriantorrejongerardo biosynthesisofhemeoinintraerythrocyticstagesofplasmodiumfalciparumandpotentialinhibitorsofthispathway AT almeidafernandog biosynthesisofhemeoinintraerythrocyticstagesofplasmodiumfalciparumandpotentialinhibitorsofthispathway AT cirullibrendaanalia biosynthesisofhemeoinintraerythrocyticstagesofplasmodiumfalciparumandpotentialinhibitorsofthispathway AT katzinalejandrom biosynthesisofhemeoinintraerythrocyticstagesofplasmodiumfalciparumandpotentialinhibitorsofthispathway
bdutipo_str	Repositorios
_version_	1764820410235355136

Biosynthesis of heme O in intraerythrocytic stages of Plasmodium falciparum and potential inhibitors of this pathway

Ejemplares similares