Tuberculosis, the Disrupted Immune-Endocrine Response and the Potential Thymic Repercussion As a Contributing Factor to Disease Physiopathology

Upon the pathogen encounter, the host seeks to ensure an adequate inflammatory reaction to combat infection but at the same time tries to prevent collateral damage, through several regulatory mechanisms, like an endocrine response involving the production of adrenal steroid hormones. Our studies sho...

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Autores principales: D'Attilio, Luciano, Santucci, Natalia, Bongiovanni, Bettina, Bay, María Luisa, Bottasso, Oscar
Formato: article artículo publishedVersion
Lenguaje:Inglés
Publicado: Frontiers Research Foundation 2019
Materias:
Tuberculosis
Immune-endocrine communication
Inflammation
Thymic involution
Pathophysiology
Hormones
Acceso en línea:http://hdl.handle.net/2133/14382
http://hdl.handle.net/2133/14382
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
id I15-R121-2133-14382
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Inglés
orig_language_str_mv eng
topic Tuberculosis
Immune-endocrine communication
Inflammation
Thymic involution
Pathophysiology
Hormones
spellingShingle Tuberculosis
Immune-endocrine communication
Inflammation
Thymic involution
Pathophysiology
Hormones
D'Attilio, Luciano
Santucci, Natalia
Bongiovanni, Bettina
Bay, María Luisa
Bottasso, Oscar
Tuberculosis, the Disrupted Immune-Endocrine Response and the Potential Thymic Repercussion As a Contributing Factor to Disease Physiopathology
topic_facet Tuberculosis
Immune-endocrine communication
Inflammation
Thymic involution
Pathophysiology
Hormones
description Upon the pathogen encounter, the host seeks to ensure an adequate inflammatory reaction to combat infection but at the same time tries to prevent collateral damage, through several regulatory mechanisms, like an endocrine response involving the production of adrenal steroid hormones. Our studies show that active tuberculosis (TB) patients present an immune-endocrine imbalance characterized by an impaired cellular immunity together with increased plasma levels of cortisol, pro-inflammatory cytokines, and decreased amounts of dehydroepiandrosterone. Studies in patients undergoing specific treatment revealed that cortisol levels remained increased even after several months of initiating therapy. In addition to the well-known metabolic and immunological effects, glucocorticoids are involved in thymic cortical depletion with immature thymocytes being quite sensitive to such an effect. The thymus is a central lymphoid organ supporting thymocyte T-cell development, i.e., lineage commitment, selection events and thymic emigration. While thymic TB is an infrequent manifestation of the disease, several pieces of experimental and clinical evidence point out that the thymus can be infected by mycobacteria. Beyond this, the thymic microenvironment during TB may be also altered because of the immune-hormonal alterations. The thymus may be then an additional target of organ involvement further contributing to a deficient control of infection and disease immunopathology.
format article
artículo
publishedVersion
author D'Attilio, Luciano
Santucci, Natalia
Bongiovanni, Bettina
Bay, María Luisa
Bottasso, Oscar
author_facet D'Attilio, Luciano
Santucci, Natalia
Bongiovanni, Bettina
Bay, María Luisa
Bottasso, Oscar
author_sort D'Attilio, Luciano
title Tuberculosis, the Disrupted Immune-Endocrine Response and the Potential Thymic Repercussion As a Contributing Factor to Disease Physiopathology
title_short Tuberculosis, the Disrupted Immune-Endocrine Response and the Potential Thymic Repercussion As a Contributing Factor to Disease Physiopathology
title_full Tuberculosis, the Disrupted Immune-Endocrine Response and the Potential Thymic Repercussion As a Contributing Factor to Disease Physiopathology
title_fullStr Tuberculosis, the Disrupted Immune-Endocrine Response and the Potential Thymic Repercussion As a Contributing Factor to Disease Physiopathology
title_full_unstemmed Tuberculosis, the Disrupted Immune-Endocrine Response and the Potential Thymic Repercussion As a Contributing Factor to Disease Physiopathology
title_sort tuberculosis, the disrupted immune-endocrine response and the potential thymic repercussion as a contributing factor to disease physiopathology
publisher Frontiers Research Foundation
publishDate 2019
url http://hdl.handle.net/2133/14382
http://hdl.handle.net/2133/14382
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bdutipo_str Repositorios
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