Dysregulated Network of Immune, Endocrine and Metabolic Markers is Associated to More Severe Human Chronic Chagas Cardiomyopathy

Individuals who are infected with Trypanosoma cruzi develop chronic Chagas cardiomyopathy (CCC), which is a complication involving a series of immune pathogenetic mechanisms, although an association between immune and metabolic alterations was more recently proposed. Accordingly, we investigated the...

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Autores principales: González, Florencia Belén, Villar, Silvina Raquel, D'Attilio, Luciano, Leiva, Rodolfo, Marquez, Julia, Lioi, Susana, Beloscar, Juan, Bottasso, Oscar, Pérez, Ana Rosa
Formato: article artículo publishedVersion
Lenguaje:Inglés
Publicado: S. Karger AG 2019
Materias:
Chagas disease
Immuno-metabolism
Cortisol
Tumor necrosis factor-α
Interleukin-6
Adipocytokines
Tumor necrosis factor-α receptor type-1
Acceso en línea:http://hdl.handle.net/2133/14381
http://hdl.handle.net/2133/14381
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
id I15-R121-2133-14381
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Inglés
orig_language_str_mv eng
topic Chagas disease
Immuno-metabolism
Cortisol
Tumor necrosis factor-α
Interleukin-6
Adipocytokines
Tumor necrosis factor-α receptor type-1
spellingShingle Chagas disease
Immuno-metabolism
Cortisol
Tumor necrosis factor-α
Interleukin-6
Adipocytokines
Tumor necrosis factor-α receptor type-1
González, Florencia Belén
Villar, Silvina Raquel
D'Attilio, Luciano
Leiva, Rodolfo
Marquez, Julia
Lioi, Susana
Beloscar, Juan
Bottasso, Oscar
Pérez, Ana Rosa
Dysregulated Network of Immune, Endocrine and Metabolic Markers is Associated to More Severe Human Chronic Chagas Cardiomyopathy
topic_facet Chagas disease
Immuno-metabolism
Cortisol
Tumor necrosis factor-α
Interleukin-6
Adipocytokines
Tumor necrosis factor-α receptor type-1
description Individuals who are infected with Trypanosoma cruzi develop chronic Chagas cardiomyopathy (CCC), which is a complication involving a series of immune pathogenetic mechanisms, although an association between immune and metabolic alterations was more recently proposed. Accordingly, we investigated the immuno-metabolic response in chagasic patients and their possible influence on CCC pathogenesis. To this end, T. cruzi-seropositive (asymptomatic or with CCC) and sero-negative individuals were studied. Serum tumour necrosis factor (TNF)-α, interleukin (IL)-6, adipocytokines and the expression of their receptors in peripheral blood mononuclear cell (PBMC) were evaluated, together with other factors influencing the immune response. CCC patients showed major metabolic and hormonal abnormalities, in parallel with increased IL-6 and leptin serum levels. TNF-α receptor s, leptin and adiponectin receptors (ObR and Adipo-Rs respectively), as well as PPAR-γ expression in PBMCs from CCC patients were compatible with a counteracting response leading to an unfavourable immune-metabolic profile. These results suggest that persistently increased levels of immune-metabolic pro-inflammatory mediators along with the adverse endocrine anti-inflammatory response of CCC individuals, may contribute to the underlying mechanisms dealing with myocardial tissue damage.
format article
artículo
publishedVersion
author González, Florencia Belén
Villar, Silvina Raquel
D'Attilio, Luciano
Leiva, Rodolfo
Marquez, Julia
Lioi, Susana
Beloscar, Juan
Bottasso, Oscar
Pérez, Ana Rosa
author_facet González, Florencia Belén
Villar, Silvina Raquel
D'Attilio, Luciano
Leiva, Rodolfo
Marquez, Julia
Lioi, Susana
Beloscar, Juan
Bottasso, Oscar
Pérez, Ana Rosa
author_sort González, Florencia Belén
title Dysregulated Network of Immune, Endocrine and Metabolic Markers is Associated to More Severe Human Chronic Chagas Cardiomyopathy
title_short Dysregulated Network of Immune, Endocrine and Metabolic Markers is Associated to More Severe Human Chronic Chagas Cardiomyopathy
title_full Dysregulated Network of Immune, Endocrine and Metabolic Markers is Associated to More Severe Human Chronic Chagas Cardiomyopathy
title_fullStr Dysregulated Network of Immune, Endocrine and Metabolic Markers is Associated to More Severe Human Chronic Chagas Cardiomyopathy
title_full_unstemmed Dysregulated Network of Immune, Endocrine and Metabolic Markers is Associated to More Severe Human Chronic Chagas Cardiomyopathy
title_sort dysregulated network of immune, endocrine and metabolic markers is associated to more severe human chronic chagas cardiomyopathy
publisher S. Karger AG
publishDate 2019
url http://hdl.handle.net/2133/14381
http://hdl.handle.net/2133/14381
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