DLG1 polarity protein expression associates with the disease progress of low-grade cervical intraepithelial lesions

Human Disc large tumor suppressor (DLG1) participates in regulating cell polarity and proliferation, suggesting an important connection between epithelial organization and cellular growth control. However, it was demonstrated that DLG1 could acquire oncogenic attributes in some specific contexts. In...

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Autores principales: Cavatorta, Ana Laura, Di Gregorio, Alejandra, Bugnon Valdano, Marina Paula, Marziali, Federico Emanuel, Cabral, Mariela, Bottai, Hebe, Cittadini, Jorge, Nocito, Ana Lía, Gardiol, Daniela
Lenguaje:Inglés
Publicado: Elsevier 2019
Materias:
DLG1
LSIL progression
Immunohistochemistry
Cervical cancer
Acceso en línea:http://hdl.handle.net/2133/14229
http://hdl.handle.net/2133/14229
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
id I15-R121-2133-14229
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Inglés
orig_language_str_mv eng
topic DLG1
LSIL progression
Immunohistochemistry
Cervical cancer
spellingShingle DLG1
LSIL progression
Immunohistochemistry
Cervical cancer
Cavatorta, Ana Laura
Di Gregorio, Alejandra
Bugnon Valdano, Marina Paula
Marziali, Federico Emanuel
Cabral, Mariela
Bottai, Hebe
Cittadini, Jorge
Nocito, Ana Lía
Gardiol, Daniela
DLG1 polarity protein expression associates with the disease progress of low-grade cervical intraepithelial lesions
topic_facet DLG1
LSIL progression
Immunohistochemistry
Cervical cancer
description Human Disc large tumor suppressor (DLG1) participates in regulating cell polarity and proliferation, suggesting an important connection between epithelial organization and cellular growth control. However, it was demonstrated that DLG1 could acquire oncogenic attributes in some specific contexts. In this work, we evaluated the expression of DLG1 and its contribution to the progress of cervical lesions in order to investigate a potential role of this polarity protein in human oncogenic processes. We analyzed cervical biopsies from women with low-grade squamous intraepithelial lesion (LSIL) diagnosis (n=30), for DLG1 expression by immunohistochemistry. These results were correlated with the clinical monitoring of the patients during a 24-month follow-up period. Our data indicate that while all LSIL patients with a DLG1 staining pattern similar to normal tissues are significantly more likely to regress (n=23, Pattern I), all LSIL biopsy specimens showing a diffuse and intense DLG1 staining likely progress to high-grade lesions (n=4, Pattern II). Finally, all persistent LSIL analyzed showed an undetermined DLG1 staining, with a diffuse distribution without a strong intensity (n=3, Pattern III). We found a significant association between the expression pattern of DLG1 and the evolution of the lesion (p<0.00001). This work contributes to the knowledge of DLG1 biological functions, suggesting that its expression may have an important role in the progression of early dysplastic cervical lesions, giving prognostic information.
author Cavatorta, Ana Laura
Di Gregorio, Alejandra
Bugnon Valdano, Marina Paula
Marziali, Federico Emanuel
Cabral, Mariela
Bottai, Hebe
Cittadini, Jorge
Nocito, Ana Lía
Gardiol, Daniela
author_facet Cavatorta, Ana Laura
Di Gregorio, Alejandra
Bugnon Valdano, Marina Paula
Marziali, Federico Emanuel
Cabral, Mariela
Bottai, Hebe
Cittadini, Jorge
Nocito, Ana Lía
Gardiol, Daniela
author_sort Cavatorta, Ana Laura
title DLG1 polarity protein expression associates with the disease progress of low-grade cervical intraepithelial lesions
title_short DLG1 polarity protein expression associates with the disease progress of low-grade cervical intraepithelial lesions
title_full DLG1 polarity protein expression associates with the disease progress of low-grade cervical intraepithelial lesions
title_fullStr DLG1 polarity protein expression associates with the disease progress of low-grade cervical intraepithelial lesions
title_full_unstemmed DLG1 polarity protein expression associates with the disease progress of low-grade cervical intraepithelial lesions
title_sort dlg1 polarity protein expression associates with the disease progress of low-grade cervical intraepithelial lesions
publisher Elsevier
publishDate 2019
url http://hdl.handle.net/2133/14229
http://hdl.handle.net/2133/14229
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