First evidence of the interaction between deleted in malignant brain tumor 1 and galectin-3 in the mammalian oviduct

The oviduct supports the transport and final maturation of gametes, and harbors fertilization and early embryo development. The oviductal epithelium is responsible for providing the correct environment for these processes. Deleted in malignant brain tumor 1 (DMBT1) is expressed by multiple organisms...

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Detalles Bibliográficos
Autores principales: Roldán, María Lorena, Marini, Patricia Estela
Formato: article artículo acceptedVersion
Lenguaje:Inglés
Publicado: Springer 2019
Materias:
Oviduct
Fallopian tube
DMBT1
Galectin-3
Acceso en línea:http://hdl.handle.net/2133/13972
http://hdl.handle.net/2133/13972
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
id I15-R121-2133-13972
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Inglés
orig_language_str_mv eng
topic Oviduct
Fallopian tube
DMBT1
Galectin-3
spellingShingle Oviduct
Fallopian tube
DMBT1
Galectin-3
Roldán, María Lorena
Marini, Patricia Estela
First evidence of the interaction between deleted in malignant brain tumor 1 and galectin-3 in the mammalian oviduct
topic_facet Oviduct
Fallopian tube
DMBT1
Galectin-3
description The oviduct supports the transport and final maturation of gametes, and harbors fertilization and early embryo development. The oviductal epithelium is responsible for providing the correct environment for these processes. Deleted in malignant brain tumor 1 (DMBT1) is expressed by multiple organisms and several cell types, and the interaction of the rabbit ortholog of DMBT1 with galectin-3 (gal-3) modulates the polarity of epithelial cells. This interaction has not yet been shown in locations other than rabbit kidney and human-cultured endothelial cells. DMBT1 and gal-3 also protect epithelial layers from pathogens and trauma, and are innate immunity components. DMBT1 has been detected in the porcine oviduct, and gal-3 has been reported in the Fallopian tube and in the cow oviduct. Interaction between both proteins would show a probable physiological function in the female reproductive tract. This work describes the presence and co-localization of DMBT1 and gal-3 mainly in the apical region of the epithelial cells of the Fallopian tube and the porcine oviduct, and co-immunoprecipitation in membrane-enriched epithelial cell extracts from the porcine oviduct. The findings strongly support a functional interaction in the mammalian oviduct, suggestive of a role on epithelial protection and homeostasis, which might be related to epithelium–gamete interaction.
format article
artículo
acceptedVersion
author Roldán, María Lorena
Marini, Patricia Estela
author_facet Roldán, María Lorena
Marini, Patricia Estela
author_sort Roldán, María Lorena
title First evidence of the interaction between deleted in malignant brain tumor 1 and galectin-3 in the mammalian oviduct
title_short First evidence of the interaction between deleted in malignant brain tumor 1 and galectin-3 in the mammalian oviduct
title_full First evidence of the interaction between deleted in malignant brain tumor 1 and galectin-3 in the mammalian oviduct
title_fullStr First evidence of the interaction between deleted in malignant brain tumor 1 and galectin-3 in the mammalian oviduct
title_full_unstemmed First evidence of the interaction between deleted in malignant brain tumor 1 and galectin-3 in the mammalian oviduct
title_sort first evidence of the interaction between deleted in malignant brain tumor 1 and galectin-3 in the mammalian oviduct
publisher Springer
publishDate 2019
url http://hdl.handle.net/2133/13972
http://hdl.handle.net/2133/13972
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AT marinipatriciaestela firstevidenceoftheinteractionbetweendeletedinmalignantbraintumor1andgalectin3inthemammalianoviduct
bdutipo_str Repositorios
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