Attenuation of liver cancer development by oral glycerol supplementation in the rat

PURPOSE:Glycerol usage is increasing in food industry for human and animal nutrition. This study analyzed the impact of glycerol metabolism when orally supplemented during the early stage of rat liver carcinogenesis.METHODS:Wistar rats were subjected to a 2-phase model of hepatocarcinogenesis (initi...

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Autores principales: Capiglioni, Alejo M., Lorenzetti, Florencia, Quiroga, Ariel Darío, Parody, Juan Pablo, Ronco, María Teresa, Pisani, Gerardo Bruno, Carrillo, María Cristina, Ceballos Mancini, María Paula, Alvarez, María de Luján
Otros Autores: Rassetto, Mauricio: asistencia técnica
Formato: article artículo publishedVersion
Lenguaje:Inglés
Publicado: Springer 2018
Materias:
Apoptosis
Glycerol
Liver Preneoplasia
Oxidative Stress
Acceso en línea:http://hdl.handle.net/2133/13719
http://hdl.handle.net/2133/13719
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
id I15-R121-2133-13719
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Inglés
topic Apoptosis
Glycerol
Liver Preneoplasia
Oxidative Stress
spellingShingle Apoptosis
Glycerol
Liver Preneoplasia
Oxidative Stress
Capiglioni, Alejo M.
Lorenzetti, Florencia
Quiroga, Ariel Darío
Parody, Juan Pablo
Ronco, María Teresa
Pisani, Gerardo Bruno
Carrillo, María Cristina
Ceballos Mancini, María Paula
Alvarez, María de Luján
Attenuation of liver cancer development by oral glycerol supplementation in the rat
topic_facet Apoptosis
Glycerol
Liver Preneoplasia
Oxidative Stress
description PURPOSE:Glycerol usage is increasing in food industry for human and animal nutrition. This study analyzed the impact of glycerol metabolism when orally supplemented during the early stage of rat liver carcinogenesis.METHODS:Wistar rats were subjected to a 2-phase model of hepatocarcinogenesis (initiated-promoted, IP group). IP animals also received glycerol by gavage (200 mg/kg body weight, IPGly group).RESULTS:Glycerol treatment reduced the volume of preneoplastic lesions by decreasing the proliferative status of liver foci, increasing the expression of p53 and p21 proteins and reducing the expression of cyclin D1 and cyclin-dependent kinase 1. Besides, apoptosis was enhanced in IPGly animals, given by an increment of Bax/Bcl-2 ratio, Bad and PUMA mitochondrial expression, a concomitant increase in cytochrome c release and caspase-3 activation. Furthermore, hepatic levels of glycerol phosphate and markers of oxidative stress were increased in IPGly rats. Oxidative stress intermediates act as intracellular messengers, inducing p53 activation and changes in JNK and Erk signaling pathways, with JNK activation and Erk inhibition.CONCLUSION:The present work provides novel data concerning the preventive actions of glycerol during the development of liver cancer and represents an economically feasible intervention to treat high-risk individuals.
author2 Rassetto, Mauricio: asistencia técnica
author_facet Rassetto, Mauricio: asistencia técnica
Capiglioni, Alejo M.
Lorenzetti, Florencia
Quiroga, Ariel Darío
Parody, Juan Pablo
Ronco, María Teresa
Pisani, Gerardo Bruno
Carrillo, María Cristina
Ceballos Mancini, María Paula
Alvarez, María de Luján
format article
artículo
publishedVersion
author Capiglioni, Alejo M.
Lorenzetti, Florencia
Quiroga, Ariel Darío
Parody, Juan Pablo
Ronco, María Teresa
Pisani, Gerardo Bruno
Carrillo, María Cristina
Ceballos Mancini, María Paula
Alvarez, María de Luján
author_sort Capiglioni, Alejo M.
title Attenuation of liver cancer development by oral glycerol supplementation in the rat
title_short Attenuation of liver cancer development by oral glycerol supplementation in the rat
title_full Attenuation of liver cancer development by oral glycerol supplementation in the rat
title_fullStr Attenuation of liver cancer development by oral glycerol supplementation in the rat
title_full_unstemmed Attenuation of liver cancer development by oral glycerol supplementation in the rat
title_sort attenuation of liver cancer development by oral glycerol supplementation in the rat
publisher Springer
publishDate 2018
url http://hdl.handle.net/2133/13719
http://hdl.handle.net/2133/13719
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