Association between baseline VEGF/sVEGFR-2 and VEGF/TSP-1 ratios and response to metronomic chemotherapy using cyclophosphamide and celecoxib in patients with advanced breast cancer

Background: Metronomic chemotherapy (MCT) with cyclophosphamide (Cy) and celecoxib (Cel) has therapeutic efficacy and low toxicity profile in advanced breast cancer patients (ABCP), but no reliable biomarkers of response have been found yet that allow patient selection for treatment. AIM: To investi...

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Autores principales: Perroud, Herman A, Rico, María José, Alasino, Carlos María, Pezzotto, Stella Maris, Rozados, Viviana R., Scharovsky, O. Graciela
Formato: article artículo publishedVersion
Lenguaje:Inglés
Publicado: Indian Cancer Society and Indian Society of Oncology 2018
Materias:
Biomarkers
Celecoxib 
Cyclophosphamide
metronomic chemotherapy
Acceso en línea:http://hdl.handle.net/2133/11554
http://hdl.handle.net/2133/11554
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
id I15-R121-2133-11554
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Inglés
orig_language_str_mv eng
topic Biomarkers
Celecoxib 
Cyclophosphamide
metronomic chemotherapy
spellingShingle Biomarkers
Celecoxib 
Cyclophosphamide
metronomic chemotherapy
Perroud, Herman A
Rico, María José
Alasino, Carlos María
Pezzotto, Stella Maris
Rozados, Viviana R.
Scharovsky, O. Graciela
Association between baseline VEGF/sVEGFR-2 and VEGF/TSP-1 ratios and response to metronomic chemotherapy using cyclophosphamide and celecoxib in patients with advanced breast cancer
topic_facet Biomarkers
Celecoxib 
Cyclophosphamide
metronomic chemotherapy
description Background: Metronomic chemotherapy (MCT) with cyclophosphamide (Cy) and celecoxib (Cel) has therapeutic efficacy and low toxicity profile in advanced breast cancer patients (ABCP), but no reliable biomarkers of response have been found yet that allow patient selection for treatment. AIM: To investigate the potential role as biomarkers of pro- and antiangiogenic parameters and evaluate their response in ABCP receiving metronomic Cy 50 mg p.o./day + Cel 400 mg p.o./day. Materials and Methods: Serum levels of vascular endothelial growth factor-C (VEGF-C), soluble VEGF receptors 2 and 3 (sVEGFR-2, sVEGFR-3), were measured at different time points in 13/15 patients included in a phase II trial of MCT with Cy+Cel. Results: Serum levels of sVEGFR-2 and sVEGFR-3 increased significantly during treatment (P = 0.0392; P = 0.0066, respectively). VEGF-C showed no significant modifications. Previous determinations of VEGF and TSP-1 in the same patients were utilized. VEGF/sVEGFR-2, VEGF/TSP-1, and VEGF-C/sVEGFR-3 ratios decreased significantly along the treatment (P = 0.0092; P = 0.0072; P = 0.0141, respectively). Nonsignificant variations were observed for VEGF-C/sVEGFR-2 ratio. Baseline values of VEGF/sVEGFR-2 and VEGF/TSP-1 ratios were associated with time to progression (TTP) (P = 0.0407; P = 0.0394, respectively) meanwhile baseline VEGF was marginally significant (P = 0.0716). Patients with values lower than the 50 th percentile for both ratios showed longer TTP. Conclusions: We have identified the baseline VEGF/sVEGFR-2 and VEGF/TSP-1 ratios as potential biomarkers of response in ABCP treated metronomically with Cy+Cel. This finding warrants its confirmation in a higher number of patients.
format article
artículo
publishedVersion
author Perroud, Herman A
Rico, María José
Alasino, Carlos María
Pezzotto, Stella Maris
Rozados, Viviana R.
Scharovsky, O. Graciela
author_facet Perroud, Herman A
Rico, María José
Alasino, Carlos María
Pezzotto, Stella Maris
Rozados, Viviana R.
Scharovsky, O. Graciela
author_sort Perroud, Herman A
title Association between baseline VEGF/sVEGFR-2 and VEGF/TSP-1 ratios and response to metronomic chemotherapy using cyclophosphamide and celecoxib in patients with advanced breast cancer
title_short Association between baseline VEGF/sVEGFR-2 and VEGF/TSP-1 ratios and response to metronomic chemotherapy using cyclophosphamide and celecoxib in patients with advanced breast cancer
title_full Association between baseline VEGF/sVEGFR-2 and VEGF/TSP-1 ratios and response to metronomic chemotherapy using cyclophosphamide and celecoxib in patients with advanced breast cancer
title_fullStr Association between baseline VEGF/sVEGFR-2 and VEGF/TSP-1 ratios and response to metronomic chemotherapy using cyclophosphamide and celecoxib in patients with advanced breast cancer
title_full_unstemmed Association between baseline VEGF/sVEGFR-2 and VEGF/TSP-1 ratios and response to metronomic chemotherapy using cyclophosphamide and celecoxib in patients with advanced breast cancer
title_sort association between baseline vegf/svegfr-2 and vegf/tsp-1 ratios and response to metronomic chemotherapy using cyclophosphamide and celecoxib in patients with advanced breast cancer
publisher Indian Cancer Society and Indian Society of Oncology
publishDate 2018
url http://hdl.handle.net/2133/11554
http://hdl.handle.net/2133/11554
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