Are Changes in the Wnt/β-Catenin Pathway Involved in Cocaine and Stress-Induced Long-Term Neuroadaptations?

Drug addiction has been defined as a chronic relapsing brain disease, characterized by compulsive drug seeking and use, despite harmful consequences. This phenomenon has been extensively studied and the use of animal models has contributed to elucidate neurobiological bases of the different stag...

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Detalles Bibliográficos
Autores principales: Cuesta, Santiago, Pacchioni, Alejandra María
Otros Autores: Cerchiara, Florencia: for their English technical assistance
Formato: article artículo publishedVersion
Lenguaje:Inglés
Publicado: Elyns Group 2018
Materias:
Cocaine
Sensitization
Stress
Vulnerability to Addiction
Acceso en línea:http://hdl.handle.net/2133/11427
http://hdl.handle.net/2133/11427
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
id I15-R121-2133-11427
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Inglés
orig_language_str_mv eng
topic Cocaine
Sensitization
Stress
Vulnerability to Addiction
spellingShingle Cocaine
Sensitization
Stress
Vulnerability to Addiction
Cuesta, Santiago
Pacchioni, Alejandra María
Are Changes in the Wnt/β-Catenin Pathway Involved in Cocaine and Stress-Induced Long-Term Neuroadaptations?
topic_facet Cocaine
Sensitization
Stress
Vulnerability to Addiction
description Drug addiction has been defined as a chronic relapsing brain disease, characterized by compulsive drug seeking and use, despite harmful consequences. This phenomenon has been extensively studied and the use of animal models has contributed to elucidate neurobiological bases of the different stages in the addiction process. For the past years, we have been studying the role of the Wnt (Wingless-related integration site) pathways in cocaine-induce neuroadaptations by using the behavioral sensitization paradigm to model addiction-like behaviors. The Wnt pathways are critical during the development of both the central and peripheral nervous systems. In particular, we centered our attention on the Wnt/β-catenin or canonical pathway. This pathway mediates the stabilization and nuclear translocation of the final effector β-catenin, where it can promote the expression of different target genes. Our findings reveal a specific spatiotemporal participation of the Wnt/β-catenin pathway in cocaine-induced behavioral sensitization. We found that while the initiation or development of sensitization involves an inhibition in the Prefrontal Cortex’s canonical pathway, the expression is related with activation in the Nucleus Accumbens. Furthermore, we recently discover that stress during adolescence has an impact on cocaine-induced effect in adulthood. Intriguingly, we also found that the exposure to this early life stress influence the activity of the Wnt/β-catenin pathway, proposing that this signaling pathway could be mediating the proactive effect of stress on drug properties. In this manuscript, we cover different mechanisms that may underlie cocaine- and stress-induced changes in the Wnt canonical pathway. We also revise the idea of this pathway as a common target for adolescent stress and for the vulnerability to drug abuse later in life. We suggest that the canonical Wnt pathway constitutes a promising target that may open a door to new therapeutic strategies for the treatment of cocaine addiction.
author2 Cerchiara, Florencia: for their English technical assistance
author_facet Cerchiara, Florencia: for their English technical assistance
Cuesta, Santiago
Pacchioni, Alejandra María
format article
artículo
publishedVersion
author Cuesta, Santiago
Pacchioni, Alejandra María
author_sort Cuesta, Santiago
title Are Changes in the Wnt/β-Catenin Pathway Involved in Cocaine and Stress-Induced Long-Term Neuroadaptations?
title_short Are Changes in the Wnt/β-Catenin Pathway Involved in Cocaine and Stress-Induced Long-Term Neuroadaptations?
title_full Are Changes in the Wnt/β-Catenin Pathway Involved in Cocaine and Stress-Induced Long-Term Neuroadaptations?
title_fullStr Are Changes in the Wnt/β-Catenin Pathway Involved in Cocaine and Stress-Induced Long-Term Neuroadaptations?
title_full_unstemmed Are Changes in the Wnt/β-Catenin Pathway Involved in Cocaine and Stress-Induced Long-Term Neuroadaptations?
title_sort are changes in the wnt/β-catenin pathway involved in cocaine and stress-induced long-term neuroadaptations?
publisher Elyns Group
publishDate 2018
url http://hdl.handle.net/2133/11427
http://hdl.handle.net/2133/11427
work_keys_str_mv AT cuestasantiago arechangesinthewntbcateninpathwayinvolvedincocaineandstressinducedlongtermneuroadaptations
AT pacchionialejandramaria arechangesinthewntbcateninpathwayinvolvedincocaineandstressinducedlongtermneuroadaptations
bdutipo_str Repositorios
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