Comparative Effectiveness of Two Metronomic Chemotherapy Schedules. Our Experience in the Preclinical Field

Metronomic chemotherapy refers to the chronic, equally spaced, delivery of low doses of chemotherapeutic drugs, without extended interruptions. Previously, we developed two combined metronomic schemes for the treatment of murine mammary tumors. The aim of this study was to compare their effects on t...

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Autores principales: Rico, María José, Perroud, Herman A, Mainetti, Leandro Ernesto, Rozados, Viviana R., Scharovsky, O. Graciela
Formato: article artículo acceptedVersion
Lenguaje:Inglés
Publicado: Taylor & Francis 2018
Materias:
Metronomic chemotherapy
Combined treatment
Cyclophosphamide
Doxorubicin
Celecoxib
 Mammary adenocarcinomas
Acceso en línea:http://hdl.handle.net/2133/11113
http://hdl.handle.net/2133/11113
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
id I15-R121-2133-11113
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Inglés
orig_language_str_mv eng
topic Metronomic chemotherapy
Combined treatment
Cyclophosphamide
Doxorubicin
Celecoxib
 Mammary adenocarcinomas
spellingShingle Metronomic chemotherapy
Combined treatment
Cyclophosphamide
Doxorubicin
Celecoxib
 Mammary adenocarcinomas
Rico, María José
Perroud, Herman A
Mainetti, Leandro Ernesto
Rozados, Viviana R.
Scharovsky, O. Graciela
Comparative Effectiveness of Two Metronomic Chemotherapy Schedules. Our Experience in the Preclinical Field
topic_facet Metronomic chemotherapy
Combined treatment
Cyclophosphamide
Doxorubicin
Celecoxib
 Mammary adenocarcinomas
description Metronomic chemotherapy refers to the chronic, equally spaced, delivery of low doses of chemotherapeutic drugs, without extended interruptions. Previously, we developed two combined metronomic schemes for the treatment of murine mammary tumors. The aim of this study was to compare their effects on tumor and metastasis growth, survival, and toxicity. Metronomic chemotherapy with Cyclophosphamide + Celecoxib (Cy + Cel) showed higher antimetastatic power than Cyclophosphamide + Doxorubicin (Cy + Dox), while being similar in other aspects. That difference, plus the advantage that represents its oral administration, suggests that the Cy + Cel combination is more suitable than Cy + Dox for metronomic chemotherapy of mammary tumors and could be proposed to the translation to the clinic.
format article
artículo
acceptedVersion
author Rico, María José
Perroud, Herman A
Mainetti, Leandro Ernesto
Rozados, Viviana R.
Scharovsky, O. Graciela
author_facet Rico, María José
Perroud, Herman A
Mainetti, Leandro Ernesto
Rozados, Viviana R.
Scharovsky, O. Graciela
author_sort Rico, María José
title Comparative Effectiveness of Two Metronomic Chemotherapy Schedules. Our Experience in the Preclinical Field
title_short Comparative Effectiveness of Two Metronomic Chemotherapy Schedules. Our Experience in the Preclinical Field
title_full Comparative Effectiveness of Two Metronomic Chemotherapy Schedules. Our Experience in the Preclinical Field
title_fullStr Comparative Effectiveness of Two Metronomic Chemotherapy Schedules. Our Experience in the Preclinical Field
title_full_unstemmed Comparative Effectiveness of Two Metronomic Chemotherapy Schedules. Our Experience in the Preclinical Field
title_sort comparative effectiveness of two metronomic chemotherapy schedules. our experience in the preclinical field
publisher Taylor & Francis
publishDate 2018
url http://hdl.handle.net/2133/11113
http://hdl.handle.net/2133/11113
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AT rozadosvivianar comparativeeffectivenessoftwometronomicchemotherapyschedulesourexperienceinthepreclinicalfield
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