Lessons from the Fourth Metronomic and Anti-angiogenic Therapy Meeting, 24–25 June 2014, Milan
The Fourth Metronomic and Anti-angiogenic Therapy Meeting was held in Milan 24–25 June 2014. The meeting was a true translational meeting where researchers and clinicians shared their results, experiences, and insights in order to continue gathering useful evidence on metronomic approaches. Several...
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| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | article artículo publishedVersion |
| Lenguaje: | Inglés |
| Publicado: |
European Institute of Oncology.OECI
2018
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| Materias: | |
| Acceso en línea: | http://hdl.handle.net/2133/11095 http://hdl.handle.net/2133/11095 |
| Aporte de: |
| id |
I15-R121-2133-11095 |
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| record_format |
dspace |
| institution |
Universidad Nacional de Rosario |
| institution_str |
I-15 |
| repository_str |
R-121 |
| collection |
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) |
| language |
Inglés |
| orig_language_str_mv |
eng |
| topic |
metronomic chemotherapy cancer Drug repurposing Anti-angiogenesis Pharmacoeconomics Adult Child |
| spellingShingle |
metronomic chemotherapy cancer Drug repurposing Anti-angiogenesis Pharmacoeconomics Adult Child Bouche, Gauthier André, Nicolas Banavali, Shripad Berthold, Frank Berruti, Alfredo Bocci, Guido Brandi, Giovanni Cavallaro, Ugo Cinieri, Saviero Colleoni, Marco Curigliano, Giuseppe Di Desidero, Teresa Eniu, Alexandru Fazio, Nicola Kerbel, Robert Hutchinson, Lisa Ledzewicz, Urszula Munzone, Elisabetta Pasquier, Eddy Scharovsky, O. Graciela Shaked, Yuval Štěrba, Jaroslav Villalba, Martin Bertolini, Francesco Lessons from the Fourth Metronomic and Anti-angiogenic Therapy Meeting, 24–25 June 2014, Milan |
| topic_facet |
metronomic chemotherapy cancer Drug repurposing Anti-angiogenesis Pharmacoeconomics Adult Child |
| description |
The Fourth Metronomic and Anti-angiogenic Therapy Meeting was held in Milan 24–25 June 2014. The meeting was a true translational meeting where researchers and clinicians shared their results, experiences, and insights in order to continue gathering useful evidence on metronomic approaches. Several speakers emphasised that exact mechanisms of action, best timing, and optimal dosage are still not well understood and that the field would learn a lot from ancillary studies performed during the clinical trials of metronomic chemotherapies. From the pre-clinical side, new research findings indicate additional possible mechanisms of actions of metronomic schedule on the immune and blood vessel compartments of the tumour micro-environment. New clinical results of metronomic chemotherapy were presented in particular in paediatric cancers [especially neuroblastoma and central nervous system (CNS) tumours], in angiosarcoma (together with beta-blockers), in hepatocellular carcinoma, in prostate cancer, and in breast cancer. The use of repurposed drugs such as metformin, celecoxib, or valproic acid in the metronomic regimen was reported and highlighted the potential of other candidate drugs to be repurposed. The clinical experiences from low- and middle-income countries with affordable regimens gave very encouraging results which will allow more patients to be effectively treated in economies where new drugs are not accessible. Looking at the impact of metronomic approaches that have been shown to be effective, it was admitted that those approaches were rarely used in clinical practice, in part because of the absence of commercial interest for companies. However, performing well-designed clinical trials of metronomic and repurposing approaches demonstrating substantial improvement, especially in populations with the greatest unmet needs, may be an easier solution than addressing the financial issue. Metronomics should always be seen as a chance to come up with new innovative affordable approaches and not as a cheap rescue strategy. |
| format |
article artículo publishedVersion |
| author |
Bouche, Gauthier André, Nicolas Banavali, Shripad Berthold, Frank Berruti, Alfredo Bocci, Guido Brandi, Giovanni Cavallaro, Ugo Cinieri, Saviero Colleoni, Marco Curigliano, Giuseppe Di Desidero, Teresa Eniu, Alexandru Fazio, Nicola Kerbel, Robert Hutchinson, Lisa Ledzewicz, Urszula Munzone, Elisabetta Pasquier, Eddy Scharovsky, O. Graciela Shaked, Yuval Štěrba, Jaroslav Villalba, Martin Bertolini, Francesco |
| author_facet |
Bouche, Gauthier André, Nicolas Banavali, Shripad Berthold, Frank Berruti, Alfredo Bocci, Guido Brandi, Giovanni Cavallaro, Ugo Cinieri, Saviero Colleoni, Marco Curigliano, Giuseppe Di Desidero, Teresa Eniu, Alexandru Fazio, Nicola Kerbel, Robert Hutchinson, Lisa Ledzewicz, Urszula Munzone, Elisabetta Pasquier, Eddy Scharovsky, O. Graciela Shaked, Yuval Štěrba, Jaroslav Villalba, Martin Bertolini, Francesco |
| author_sort |
Bouche, Gauthier |
| title |
Lessons from the Fourth Metronomic and Anti-angiogenic Therapy Meeting, 24–25 June 2014, Milan |
| title_short |
Lessons from the Fourth Metronomic and Anti-angiogenic Therapy Meeting, 24–25 June 2014, Milan |
| title_full |
Lessons from the Fourth Metronomic and Anti-angiogenic Therapy Meeting, 24–25 June 2014, Milan |
| title_fullStr |
Lessons from the Fourth Metronomic and Anti-angiogenic Therapy Meeting, 24–25 June 2014, Milan |
| title_full_unstemmed |
Lessons from the Fourth Metronomic and Anti-angiogenic Therapy Meeting, 24–25 June 2014, Milan |
| title_sort |
lessons from the fourth metronomic and anti-angiogenic therapy meeting, 24–25 june 2014, milan |
| publisher |
European Institute of Oncology.OECI |
| publishDate |
2018 |
| url |
http://hdl.handle.net/2133/11095 http://hdl.handle.net/2133/11095 |
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