Therapeutic efficacy of metronomic chemotherapy with cyclophosphamide and doxorubicin on murine mammary adenocarcinomas

Metronomic chemotherapy (MCT) involves the chronic administration of doses of chemotherapy drugs that are below the maximum tolerated dose (MTD), at frequent and regular intervals, without extended rest periods [1]. It aims to achieve a balance between efficacy in tumor killing and lack of toxicity....

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Mainetti, Leandro Ernesto, Rico, María José, Fernández Zenobi, María Virginia, Perroud, Herman A., Roggero, Eduardo, Rozados, Viviana R., Scharovsky, O. Graciela
Formato: article artículo publishedVersion
Lenguaje:Inglés
Publicado: Oxford University Press 2018
Materias:
Angiogenesis
Cyclophosphamide
doxorubicin
toxicity
Acceso en línea:http://hdl.handle.net/2133/11094
http://hdl.handle.net/2133/11094
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
id I15-R121-2133-11094
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Inglés
orig_language_str_mv eng
topic Angiogenesis
Cyclophosphamide
doxorubicin
toxicity
spellingShingle Angiogenesis
Cyclophosphamide
doxorubicin
toxicity
Mainetti, Leandro Ernesto
Rico, María José
Fernández Zenobi, María Virginia
Perroud, Herman A.
Roggero, Eduardo
Rozados, Viviana R.
Scharovsky, O. Graciela
Therapeutic efficacy of metronomic chemotherapy with cyclophosphamide and doxorubicin on murine mammary adenocarcinomas
topic_facet Angiogenesis
Cyclophosphamide
doxorubicin
toxicity
description Metronomic chemotherapy (MCT) involves the chronic administration of doses of chemotherapy drugs that are below the maximum tolerated dose (MTD), at frequent and regular intervals, without extended rest periods [1]. It aims to achieve a balance between efficacy in tumor killing and lack of toxicity. The inhibition of angiogenesis would explain its therapeutic effect [2, 3]. We have demonstrated the antitumor efficacy of MCT with cyclophosphamide (Cy) as a single drug [4] and in combination with celecoxib on mice mammary adenocarcinomas (MA) [5]. Considering the high incidence of mammary tumors in humans, in this study, we analyze the therapeutic efficacy, toxicity and mechanism/s of action of MCT combining Cy and doxorubicin (Dox), in mouse MA tumor-models.
format article
artículo
publishedVersion
author Mainetti, Leandro Ernesto
Rico, María José
Fernández Zenobi, María Virginia
Perroud, Herman A.
Roggero, Eduardo
Rozados, Viviana R.
Scharovsky, O. Graciela
author_facet Mainetti, Leandro Ernesto
Rico, María José
Fernández Zenobi, María Virginia
Perroud, Herman A.
Roggero, Eduardo
Rozados, Viviana R.
Scharovsky, O. Graciela
author_sort Mainetti, Leandro Ernesto
title Therapeutic efficacy of metronomic chemotherapy with cyclophosphamide and doxorubicin on murine mammary adenocarcinomas
title_short Therapeutic efficacy of metronomic chemotherapy with cyclophosphamide and doxorubicin on murine mammary adenocarcinomas
title_full Therapeutic efficacy of metronomic chemotherapy with cyclophosphamide and doxorubicin on murine mammary adenocarcinomas
title_fullStr Therapeutic efficacy of metronomic chemotherapy with cyclophosphamide and doxorubicin on murine mammary adenocarcinomas
title_full_unstemmed Therapeutic efficacy of metronomic chemotherapy with cyclophosphamide and doxorubicin on murine mammary adenocarcinomas
title_sort therapeutic efficacy of metronomic chemotherapy with cyclophosphamide and doxorubicin on murine mammary adenocarcinomas
publisher Oxford University Press
publishDate 2018
url http://hdl.handle.net/2133/11094
http://hdl.handle.net/2133/11094
work_keys_str_mv AT mainettileandroernesto therapeuticefficacyofmetronomicchemotherapywithcyclophosphamideanddoxorubicinonmurinemammaryadenocarcinomas
AT ricomariajose therapeuticefficacyofmetronomicchemotherapywithcyclophosphamideanddoxorubicinonmurinemammaryadenocarcinomas
AT fernandezzenobimariavirginia therapeuticefficacyofmetronomicchemotherapywithcyclophosphamideanddoxorubicinonmurinemammaryadenocarcinomas
AT perroudhermana therapeuticefficacyofmetronomicchemotherapywithcyclophosphamideanddoxorubicinonmurinemammaryadenocarcinomas
AT roggeroeduardo therapeuticefficacyofmetronomicchemotherapywithcyclophosphamideanddoxorubicinonmurinemammaryadenocarcinomas
AT rozadosvivianar therapeuticefficacyofmetronomicchemotherapywithcyclophosphamideanddoxorubicinonmurinemammaryadenocarcinomas
AT scharovskyograciela therapeuticefficacyofmetronomicchemotherapywithcyclophosphamideanddoxorubicinonmurinemammaryadenocarcinomas
bdutipo_str Repositorios
_version_ 1764820406561144834

Ejemplares similares