Efectos adversos cardíacos de la domperidona en pacientes adultos : revisión sistemática

Background: Domperidone is widely prescribed in patients with gastrointestinal disorders but some cardiac adverse effects have been recently reported. Aim: To evaluate the risk of QT prolongation, ventricular arrhythmias and sudden cardiac death associated with the use of oral domperidone in adults...

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Autores principales: Marzi, Marta Mónica, Weitz, Darío, Avila, Aylén, Molina, Gabriel, Caraballo, Lucía, Piskulic, Laura
Formato: article artículo publishedVersion
Lenguaje:Español
Publicado: Sociedad Médica de Santiago 2018
Materias:
Arrhythmias, Cardiac
Domperidone
Long QT
Review
Arritmias Cardíacas
Domperidona
Acceso en línea:http://hdl.handle.net/2133/10526
http://hdl.handle.net/2133/10526
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
id I15-R121-2133-10526
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Español
orig_language_str_mv spa
topic Arrhythmias, Cardiac
Domperidone
Long QT
Review
Arritmias Cardíacas
Domperidona
spellingShingle Arrhythmias, Cardiac
Domperidone
Long QT
Review
Arritmias Cardíacas
Domperidona
Marzi, Marta Mónica
Weitz, Darío
Avila, Aylén
Molina, Gabriel
Caraballo, Lucía
Piskulic, Laura
Efectos adversos cardíacos de la domperidona en pacientes adultos : revisión sistemática
topic_facet Arrhythmias, Cardiac
Domperidone
Long QT
Review
Arritmias Cardíacas
Domperidona
description Background: Domperidone is widely prescribed in patients with gastrointestinal disorders but some cardiac adverse effects have been recently reported. Aim: To evaluate the risk of QT prolongation, ventricular arrhythmias and sudden cardiac death associated with the use of oral domperidone in adults without cancer. Material and Methods: Systematic searches in MEDLINE, LILACS, SciELO, the Cochrane Library and regulatory agencies websites were performed, followed by a manual search of cited references. The search strategy consisted of combining free and indexed text words without any date or language restriction. Results: Three case-control studies met the inclusion criteria; none of them evaluated QT interval prolongation. With low risk of bias, each study quantified the risk of ventricular arrhythmia or sudden cardiac death (VA/SCD). The odds ratios for these events in these studies were 4.7 (95% confidence interval (CI): 1.4-16), 1.59 (95% CI: 1.28-1.98) and 11.02 (95% CI: 2.02-62.3) respectively. A significantly increased risk was observed in patients older than 60 years of age or receiving doses > 30 mg/day. Conclusions: Heterogeneity between selected studies did not allow the computation of a summary measure. However, evidence was found that an increased risk of VA/SCD is associated with the use of oral domperidone in adults.
format article
artículo
publishedVersion
author Marzi, Marta Mónica
Weitz, Darío
Avila, Aylén
Molina, Gabriel
Caraballo, Lucía
Piskulic, Laura
author_facet Marzi, Marta Mónica
Weitz, Darío
Avila, Aylén
Molina, Gabriel
Caraballo, Lucía
Piskulic, Laura
author_sort Marzi, Marta Mónica
title Efectos adversos cardíacos de la domperidona en pacientes adultos : revisión sistemática
title_short Efectos adversos cardíacos de la domperidona en pacientes adultos : revisión sistemática
title_full Efectos adversos cardíacos de la domperidona en pacientes adultos : revisión sistemática
title_fullStr Efectos adversos cardíacos de la domperidona en pacientes adultos : revisión sistemática
title_full_unstemmed Efectos adversos cardíacos de la domperidona en pacientes adultos : revisión sistemática
title_sort efectos adversos cardíacos de la domperidona en pacientes adultos : revisión sistemática
publisher Sociedad Médica de Santiago
publishDate 2018
url http://hdl.handle.net/2133/10526
http://hdl.handle.net/2133/10526
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bdutipo_str Repositorios
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