Quercetin prevents liver carcinogenesis by inducing cell cycle arrest, decreasing cell proliferation and enhancing apoptosis
Quercetin is the most abundant flavonoid in human diet. It has special interest since it holds anticancerous properties. This study aims to clarify the mechanisms involved in quercetin effects during the occurrence of preneoplastic lesions in rat liver. Adult male Wistar rats were subjected to a two...
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| Autores principales: | , , , , , , , , , , |
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| Formato: | article artículo publishedVersion |
| Lenguaje: | Inglés |
| Publicado: |
Wiley
2018
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| Acceso en línea: | http://hdl.handle.net/2133/10486 http://hdl.handle.net/2133/10486 |
| Aporte de: |
| id |
I15-R121-2133-10486 |
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| record_format |
dspace |
| institution |
Universidad Nacional de Rosario |
| institution_str |
I-15 |
| repository_str |
R-121 |
| collection |
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) |
| language |
Inglés |
| topic |
Liver Preneoplasia Quercetin Cell Cycle Apoptosis |
| spellingShingle |
Liver Preneoplasia Quercetin Cell Cycle Apoptosis Casella, María Laura Parody, Juan Pablo Ceballos Mancini, María Paula Quiroga, Ariel Darío Ronco, María Teresa Francés, Daniel Eleazar Monti, Juan Alberto Pisani, Gerardo Bruno Carnovale, Cristina Ester Carrillo, María Cristina Álvarez, María de Luján Quercetin prevents liver carcinogenesis by inducing cell cycle arrest, decreasing cell proliferation and enhancing apoptosis |
| topic_facet |
Liver Preneoplasia Quercetin Cell Cycle Apoptosis |
| description |
Quercetin is the most abundant flavonoid in human diet. It has special interest since it holds anticancerous properties. This study aims to clarify the mechanisms involved in quercetin effects during the occurrence of preneoplastic lesions in rat liver. Adult male Wistar rats were subjected to a two-phase model of hepatocarcinogenesis (IP group). IP animals also received quercetin 10 and 20 mg/kg body weight (IPQ10 and IPQ20 groups, respectively). Antioxidant defenses were modified by quercetin administration at both doses. However, only IPQ20 group showed a reduction in number and volume of preneoplastic lesions. This
group showed increased apoptosis and a reduction in the proliferative index. In addition, IPQ20 group displayed a reduction of cell percentages in G1 and S phases, accumulation in G2 and decrease in M phase, with reduced expression of cyclin D1, cyclin A, cyclin B and cdk1. Interestingly, peroxisome proliferator-activated receptor α (PPARα) levels were reduced in IPQ20 group. The outcomes of this study represent a significant contribution to the current understanding on the preventive mechanisms of quercetin during the early stages of liver cancer development, demonstrating that in addition to its known proapoptotic characteristics, the flavonoid modulates the expression of critical cell cycle
regulators and PPARα activity. |
| format |
article artículo publishedVersion |
| author |
Casella, María Laura Parody, Juan Pablo Ceballos Mancini, María Paula Quiroga, Ariel Darío Ronco, María Teresa Francés, Daniel Eleazar Monti, Juan Alberto Pisani, Gerardo Bruno Carnovale, Cristina Ester Carrillo, María Cristina Álvarez, María de Luján |
| author_facet |
Casella, María Laura Parody, Juan Pablo Ceballos Mancini, María Paula Quiroga, Ariel Darío Ronco, María Teresa Francés, Daniel Eleazar Monti, Juan Alberto Pisani, Gerardo Bruno Carnovale, Cristina Ester Carrillo, María Cristina Álvarez, María de Luján |
| author_sort |
Casella, María Laura |
| title |
Quercetin prevents liver carcinogenesis by inducing cell cycle arrest, decreasing cell proliferation and enhancing apoptosis |
| title_short |
Quercetin prevents liver carcinogenesis by inducing cell cycle arrest, decreasing cell proliferation and enhancing apoptosis |
| title_full |
Quercetin prevents liver carcinogenesis by inducing cell cycle arrest, decreasing cell proliferation and enhancing apoptosis |
| title_fullStr |
Quercetin prevents liver carcinogenesis by inducing cell cycle arrest, decreasing cell proliferation and enhancing apoptosis |
| title_full_unstemmed |
Quercetin prevents liver carcinogenesis by inducing cell cycle arrest, decreasing cell proliferation and enhancing apoptosis |
| title_sort |
quercetin prevents liver carcinogenesis by inducing cell cycle arrest, decreasing cell proliferation and enhancing apoptosis |
| publisher |
Wiley |
| publishDate |
2018 |
| url |
http://hdl.handle.net/2133/10486 http://hdl.handle.net/2133/10486 |
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