Antiphospholipid and antioangiogenic activity in females with recurrent miscarriage and antiphospholipid syndrome
Background: Antiphospholipid syndrome is an autoimmune disease characterized by thrombosis, fetal losses and thrombocytopenia associated to antiphospholipid antibodies. They are directed to phospholipids, such as cardiolipins (anticardiolipin) and lupus anticoagulant or to complexes formed by phosph...
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| Autores principales: | , , , , , , , , |
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| Formato: | article artículo acceptedVersion |
| Lenguaje: | Inglés |
| Publicado: |
SAGE
2017
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| Acceso en línea: | http://hdl.handle.net/2133/10231 http://hdl.handle.net/2133/10231 |
| Aporte de: |
| id |
I15-R121-2133-10231 |
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| record_format |
dspace |
| institution |
Universidad Nacional de Rosario |
| institution_str |
I-15 |
| repository_str |
R-121 |
| collection |
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) |
| language |
Inglés |
| orig_language_str_mv |
eng |
| topic |
Pregnancy Immunoassay Coagulation Testing |
| spellingShingle |
Pregnancy Immunoassay Coagulation Testing Pelusa, Héctor Fabián Pezzarini, Eleonora Basiglio, Cecilia Lorena Musuruana, Jorge Bearzotti, Mariela Svetaz, María José Daniele, Stella Maris Bottai, Hebe Arriaga, Sandra Mónica María Antiphospholipid and antioangiogenic activity in females with recurrent miscarriage and antiphospholipid syndrome |
| topic_facet |
Pregnancy Immunoassay Coagulation Testing |
| description |
Background: Antiphospholipid syndrome is an autoimmune disease characterized by thrombosis, fetal losses and thrombocytopenia associated to antiphospholipid antibodies. They are directed to phospholipids, such as cardiolipins (anticardiolipin) and lupus anticoagulant or to complexes formed by phospholipids and protein cofactors, such as b2
glycoprotein 1 (a-b2GP1) and annexin V (a-annexin V). These auto-antibodies may be considered as a family of antibodies involved in thrombotic events and antiphospholipid activity. On the other hand, some proangiogenic factors are involved in the normal development of placental vasculature, such as the vascular endothelial growth factor. Overexpression of vascular endothelial growth factor receptor in its soluble form (sVEGFR-1) has been associated to a higher antiangiogenic activity. Our aim was to analyse the association between anticardiolipin, lupus anticoagulant, a-b2GP1, a-annexin V and sVEGFR-1 with recurrent miscarriage before week 10 of gestation in females with antiphospholipid syndrome. Methods: We studied 24 females (primary or secondary antiphospholipid syndrome), who were divided into two groups: females with recurrent miscarriage before week 10 of gestation (M; n=12) and females with no history of
fetal loss (NM; n=12). Anticardiolipin, a-b2GP1, a-annexin V and sVEGF-R1 concentrations were assessed by ELISA, while lupus anticoagulant was assessed by screening and confirmatory tests. Results: A significant association was observed between the number of positive biomarkers and the belonging group (P<0.05). Besides, a positive result for lupus anticoagulant and a-b2GP1 was found to be significantly associated to the M group (P<0.05).
Conclusions: Lupus anticoagulant and a-b2GP1 may be implicated in pregnancies complicated by recurrent miscarriage in females with antiphospholipid syndrome. |
| format |
article artículo acceptedVersion |
| author |
Pelusa, Héctor Fabián Pezzarini, Eleonora Basiglio, Cecilia Lorena Musuruana, Jorge Bearzotti, Mariela Svetaz, María José Daniele, Stella Maris Bottai, Hebe Arriaga, Sandra Mónica María |
| author_facet |
Pelusa, Héctor Fabián Pezzarini, Eleonora Basiglio, Cecilia Lorena Musuruana, Jorge Bearzotti, Mariela Svetaz, María José Daniele, Stella Maris Bottai, Hebe Arriaga, Sandra Mónica María |
| author_sort |
Pelusa, Héctor Fabián |
| title |
Antiphospholipid and antioangiogenic activity in females with recurrent miscarriage and antiphospholipid syndrome |
| title_short |
Antiphospholipid and antioangiogenic activity in females with recurrent miscarriage and antiphospholipid syndrome |
| title_full |
Antiphospholipid and antioangiogenic activity in females with recurrent miscarriage and antiphospholipid syndrome |
| title_fullStr |
Antiphospholipid and antioangiogenic activity in females with recurrent miscarriage and antiphospholipid syndrome |
| title_full_unstemmed |
Antiphospholipid and antioangiogenic activity in females with recurrent miscarriage and antiphospholipid syndrome |
| title_sort |
antiphospholipid and antioangiogenic activity in females with recurrent miscarriage and antiphospholipid syndrome |
| publisher |
SAGE |
| publishDate |
2017 |
| url |
http://hdl.handle.net/2133/10231 http://hdl.handle.net/2133/10231 |
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Repositorios |
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