Garlic inhibitory effect on platelet activity induced by different agonists

Platelets are essential elements of human blood. In addition to their normal role, platelets are involved in causing myocardial infarction, stroke and other thrombotic disorders. Platelet activation in vivo, probably involves a combination of agonists. Garlic has beneficial effects due to its abili...

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Autores principales: González, Roxana Elizabeth, Soto, Verónica Carolina, Sance, María Mirta, Galmarini, Claudio Rómulo
Formato: Artículo revista
Lenguaje:Inglés
Publicado: Facultad de Ciencias Agrarias-UNCuyo 2021
Materias:
Allium sativum L.
Perla INTA cultivar
coagulación
efecto antiagregatorio
coagulation
antiaggregatory effect
Acceso en línea:https://revistas.uncu.edu.ar/ojs3/index.php/RFCA/article/view/4644
Aporte de:
Revista de la Facultad de Ciencias Agrarias UNCuyo de Universidad Nacional de Cuyo
id I11-R107article-4644
record_format ojs
institution Universidad Nacional de Cuyo
institution_str I-11
repository_str R-107
container_title_str Revista de la Facultad de Ciencias Agrarias UNCuyo
language Inglés
format Artículo revista
topic Allium sativum L.
Perla INTA cultivar
coagulación
efecto antiagregatorio
Allium sativum L.
Perla INTA cultivar
coagulation
antiaggregatory effect
spellingShingle Allium sativum L.
Perla INTA cultivar
coagulación
efecto antiagregatorio
Allium sativum L.
Perla INTA cultivar
coagulation
antiaggregatory effect
González, Roxana Elizabeth
Soto, Verónica Carolina
Sance, María Mirta
Galmarini, Claudio Rómulo
Garlic inhibitory effect on platelet activity induced by different agonists
topic_facet Allium sativum L.
Perla INTA cultivar
coagulación
efecto antiagregatorio
Allium sativum L.
Perla INTA cultivar
coagulation
antiaggregatory effect
author González, Roxana Elizabeth
Soto, Verónica Carolina
Sance, María Mirta
Galmarini, Claudio Rómulo
author_facet González, Roxana Elizabeth
Soto, Verónica Carolina
Sance, María Mirta
Galmarini, Claudio Rómulo
author_sort González, Roxana Elizabeth
title Garlic inhibitory effect on platelet activity induced by different agonists
title_short Garlic inhibitory effect on platelet activity induced by different agonists
title_full Garlic inhibitory effect on platelet activity induced by different agonists
title_fullStr Garlic inhibitory effect on platelet activity induced by different agonists
title_full_unstemmed Garlic inhibitory effect on platelet activity induced by different agonists
title_sort garlic inhibitory effect on platelet activity induced by different agonists
description Platelets are essential elements of human blood. In addition to their normal role, platelets are involved in causing myocardial infarction, stroke and other thrombotic disorders. Platelet activation in vivo, probably involves a combination of agonists. Garlic has beneficial effects due to its ability to inhibit platelet aggregation and thromboxane formation. The aim of this work was to evaluate the ability of garlic extracts to inhibit platelet aggregation induced by different agonists and their mixtures in different donors. Significant differences were found in platelet aggregation in response to each agonist (P ≤ 0.05). The highest antiaggregatory effect was observed with arachidonic acid and the lowest effect with collagen-arachidonic acid mixture. Interaction effects between donor and agonist (or mixtures) were detected. The study showed the potential of aqueous garlic extracts to prevent platelet aggregation induced by different agonist. Highlights Platelets play a central role in the progression of atherosclerotic lesions. Blood from nine non-smoker healthy donors was used for in vitro platelet aggregation study. Significant differences were found in platelet aggregation in response to each agonist. Aqueous garlic extracts could prevent platelet aggregation induced by different agonist.
publisher Facultad de Ciencias Agrarias-UNCuyo
publishDate 2021
url https://revistas.uncu.edu.ar/ojs3/index.php/RFCA/article/view/4644
work_keys_str_mv AT gonzalezroxanaelizabeth garlicinhibitoryeffectonplateletactivityinducedbydifferentagonists
AT sotoveronicacarolina garlicinhibitoryeffectonplateletactivityinducedbydifferentagonists
AT sancemariamirta garlicinhibitoryeffectonplateletactivityinducedbydifferentagonists
AT galmariniclaudioromulo garlicinhibitoryeffectonplateletactivityinducedbydifferentagonists
first_indexed 2022-06-20T13:53:50Z
last_indexed 2022-06-20T13:53:50Z
bdutipo_str Revistas
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