Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit

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It is known that long-term exposure to stressful situations can produce severe consequences affecting behavioral, endocrine and immunological parameters. We have previously shown that stressed BALB/c mice had poor learning performance, which was reverted by glatiramer acetate treatment through a mec...

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Autores principales: Palumbo, María Laura, Di Rosso, María Emilia, Simon, Elias Hugo, Gonzalez Murano, María Rosa, Genaro, Ana María
Formato: Artículo acceptedVersion
Lenguaje:Inglés
Publicado: Elsevier 2020
Materias:
Chronic stress
Cytokines
Hippocampus
Lymph nodes
Glatiramer acetate
Acceso en línea:http://repositorio.unnoba.edu.ar:8080/xmlui/handle/23601/108
Aporte de:
Re DI Repositorio Digital UNNOBA de Universidad Nacional del Noroeste de la Provincia de Buenos Aires
id I103-R405-23601-108
record_format dspace
institution Universidad Nacional del Noroeste de la Provincia de Buenos Aires
institution_str I-103
repository_str R-405
collection Re DI Repositorio Digital UNNOBA
language Inglés
topic Chronic stress
Cytokines
Hippocampus
Lymph nodes
Glatiramer acetate
spellingShingle Chronic stress
Cytokines
Hippocampus
Lymph nodes
Glatiramer acetate
Palumbo, María Laura
Di Rosso, María Emilia
Simon, Elias Hugo
Gonzalez Murano, María Rosa
Genaro, Ana María
Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit
topic_facet Chronic stress
Cytokines
Hippocampus
Lymph nodes
Glatiramer acetate
description It is known that long-term exposure to stressful situations can produce severe consequences affecting behavioral, endocrine and immunological parameters. We have previously shown that stressed BALB/c mice had poor learning performance, which was reverted by glatiramer acetate treatment through a mechanism that likely involved the regulation of the cytokine balance and adult neurogenesis. In addition, recent results suggest that cytokine and neurotrophin expression in the hippocampus displayed similar tendencies as those in the serum. However, if lymphoid cells could be good candidates as peripheral markers of memory impairment have not yet been investigated. For this purpose, we analyzed the spatial memory and the neutrophin and cytokine mRNA levels in lymph nodes and hippocampus in mice submitted to chronic stress treated or not with glatiramer acetate. Results indicated that there was a correlation between the cytokine and neurotrophin mRNA levels in the hippocampus and in the peripheral lymph nodes, and the cognitive performance in BALB/c mice. In particular, our results suggest that altered IFN-γ levels could be used as peripheral biomarker of cognitive deficit and treatment response.
format Artículo
Artículo
acceptedVersion
Artículo
Artículo
acceptedVersion
Artículo
Artículo
acceptedVersion
author Palumbo, María Laura
Di Rosso, María Emilia
Simon, Elias Hugo
Gonzalez Murano, María Rosa
Genaro, Ana María
author_facet Palumbo, María Laura
Di Rosso, María Emilia
Simon, Elias Hugo
Gonzalez Murano, María Rosa
Genaro, Ana María
author_sort Palumbo, María Laura
title Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit
title_short Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit
title_full Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit
title_fullStr Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit
title_full_unstemmed Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit
title_sort altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit
publisher Elsevier
publishDate 2020
url http://repositorio.unnoba.edu.ar:8080/xmlui/handle/23601/108
work_keys_str_mv AT palumbomarialaura alteredinterferongexpressioninlymphocytesasapotentialperipheralmarkerofchronicstressinducedcognitivedeficit
AT dirossomariaemilia alteredinterferongexpressioninlymphocytesasapotentialperipheralmarkerofchronicstressinducedcognitivedeficit
AT simoneliashugo alteredinterferongexpressioninlymphocytesasapotentialperipheralmarkerofchronicstressinducedcognitivedeficit
AT gonzalezmuranomariarosa alteredinterferongexpressioninlymphocytesasapotentialperipheralmarkerofchronicstressinducedcognitivedeficit
AT genaroanamaria alteredinterferongexpressioninlymphocytesasapotentialperipheralmarkerofchronicstressinducedcognitivedeficit
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spelling I103-R405-23601-1082025-10-21T20:58:36Z Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit Palumbo, María Laura Di Rosso, María Emilia Simon, Elias Hugo Gonzalez Murano, María Rosa Genaro, Ana María Chronic stress Cytokines Hippocampus Lymph nodes Glatiramer acetate It is known that long-term exposure to stressful situations can produce severe consequences affecting behavioral, endocrine and immunological parameters. We have previously shown that stressed BALB/c mice had poor learning performance, which was reverted by glatiramer acetate treatment through a mechanism that likely involved the regulation of the cytokine balance and adult neurogenesis. In addition, recent results suggest that cytokine and neurotrophin expression in the hippocampus displayed similar tendencies as those in the serum. However, if lymphoid cells could be good candidates as peripheral markers of memory impairment have not yet been investigated. For this purpose, we analyzed the spatial memory and the neutrophin and cytokine mRNA levels in lymph nodes and hippocampus in mice submitted to chronic stress treated or not with glatiramer acetate. Results indicated that there was a correlation between the cytokine and neurotrophin mRNA levels in the hippocampus and in the peripheral lymph nodes, and the cognitive performance in BALB/c mice. In particular, our results suggest that altered IFN-γ levels could be used as peripheral biomarker of cognitive deficit and treatment response. Fil: Palumbo, María Laura. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones Básicas y Aplicadas; Argentina. Fil: Palumbo, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fil: Palumbo, María Laura. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires (CITNOBA) – UNNOBA-UNSAdA-CONICET; Argentina. Fil: Di Rosso, María Emilia. Universidad de Buenos Aires. Facultad de Medicina. Primera Cátedra de Farmacología; Argentina. Fil: Di Rosso, María Emilia. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina. Fil: Di Rosso, María Emilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fil: Simón, Elías Hugo. Universidad de Buenos Aires. Facultad de Medicina. Primera Cátedra de Farmacología; Argentina. Fil: González Murano, María Rosa. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina. Fil: González Murano, María Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fil: Genaro, Ana María. Universidad de Buenos Aires. Facultad de Medicina. Primera Cátedra de Farmacología; Argentina. Fil: Genaro, Ana María. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina. Fil: Genaro, Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Con referato 2020-09-25T14:10:13Z 2020-09-25T14:10:13Z 2018-07 info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/acceptedVersion info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/acceptedVersion info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/acceptedVersion Palumbo, M. L., Di Rosso, M. E., Simon, E. H., Gonzalez Murano, M. R., y Genaro, A. M. (2018). Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit. Cytokine. http://repositorio.unnoba.edu.ar:8080/xmlui/handle/23601/108 1043-4666 http://repositorio.unnoba.edu.ar:8080/xmlui/handle/23601/108 eng info:eu-repo/grantAgreement/CONICET/PIP/11220110100792CO/AR. Ciudad de Autónoma de Buenos Aires/Red COES de Repositorios de Acceso Abierto/RCOESRAA info:eu-repo/grantAgreement/UBA/UBACyT/20020130100290BA/AR. Ciudad de Autónoma de Buenos Aires/Red COES de Repositorios de Acceso Abierto/RCOESRAA info:eu-repo/grantAgreement/ANPCyT/PICT/2013-0538/AR. Ciudad de Autónoma de Buenos Aires/Red COES de Repositorios de Acceso Abierto/RCOESRAA info:eu-repo/grantAgreement/CONICET-UNNOBA/PIO/15720150100010CO/AR. Buenos Aires/Red COES de Repositorios de Acceso Abierto/RCOESRAA https://doi.org/10.1016/j.cyto.2017.11.010 info:eu-repo/semantics/closedAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ application/pdf application/pdf image/jpeg Elsevier Cytokine

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