Alcohol-related problems: neurobiological bases of alcohol consumption and animal models developed to address these problems

The present review is focused on animal models for the study of alcohol use, abuse and dependence. These models have helped to understand several features of alcohol consumption, ranging from genetic influences to environmental factors such us early experiences with the drug. Additionally, animal mo...

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Autores principales: March, Samanta M., Miranda Morales, Roberto Sebastián
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional de Córdoba 2009
Materias:
rat
alcohol
opiate system
genetic models
rata
sistema opiáceo
bases genéticas
Acceso en línea:https://revistas.unc.edu.ar/index.php/racc/article/view/5302
Aporte de:
Revista Argentina de Ciencias del Comportamiento de Universidad Nacional de Córdoba
id I10-R363-article-5302
record_format ojs
spelling I10-R363-article-53022019-05-07T14:44:12Z Alcohol-related problems: neurobiological bases of alcohol consumption and animal models developed to address these problems Problemas Relacionados al Alcohol: Bases Neurobiológicas del consumo de alcohol y Modelos Animales desarrollados para el abordaje de estas problemáticas March, Samanta M. Miranda Morales, Roberto Sebastián rat alcohol opiate system genetic models rata alcohol sistema opiáceo bases genéticas The present review is focused on animal models for the study of alcohol use, abuse and dependence. These models have helped to understand several features of alcohol consumption, ranging from genetic influences to environmental factors such us early experiences with the drug. Additionally, animal models have been useful tools to assess the efficacy of pharmacological treatments as well as alcohol associated phenomena, such as craving, tolerance and reinstatement. First we introduce a short description of the neurobiological basis of alcohol reinforcement, focused on the opiate system. Then we cover several animal models, from genetic models, and models focused on the study of alcohol related disorders to animal models that emphasize the importance of early experiences with the drug in the development of alcohol use and alcohol related disorders. El presente trabajo se centra en los modelos animales desarrollados para el abordaje del uso, abuso y dependencia de alcohol. Estos modelos han permitido el abordaje de diversas aristas vinculadas con la ingesta de alcohol, desde las disposiciones genéticas hasta los efectos de la exposición a la droga durante el desarrollo. También han permitido la evaluación de la eficacia de tratamientos farmacológicos y de los fenómenos asociados con el abuso de la droga, como el deseo incontrolable (craving), tolerancia y recaída. El articulo comienza con una breve reseña de las bases neurobiológicas del reforzamiento etílico, principalmente el rol del sistema opiáceo. De allí se abordan diferentes modelos, se describen modelos centrados en las bases genéticas, luego se describen modelos vinculados al estudio de fenómenos específicos observados en personas con desórdenes relacionados al uso de alcohol y finalmente modelos que subrayan cómo las experiencias tempranas con la droga pueden predisponer a un consumo problemático etapas posteriores de la vida. Universidad Nacional de Córdoba 2009-09-02 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/racc/article/view/5302 10.32348/1852.4206.v1.n1.5302 Argentinean Journal of Behavioral Sciences; Vol 1, No 1 (2009): Revista Argentina de Ciencias del Comportamiento; 36-50 Revista Argentina de Ciencias del Comportamiento; Vol 1, No 1 (2009): Revista Argentina de Ciencias del Comportamiento; 36-50 1852-4206 10.32348/1852.4206.v1.n1 spa https://revistas.unc.edu.ar/index.php/racc/article/view/5302/5465 Derechos de autor 2009 Samanta M. March, Roberto Sebastián Miranda Morales
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-363
container_title_str Revista Argentina de Ciencias del Comportamiento
language Español
format Artículo revista
topic rat
alcohol
opiate system
genetic models
rata
alcohol
sistema opiáceo
bases genéticas
spellingShingle rat
alcohol
opiate system
genetic models
rata
alcohol
sistema opiáceo
bases genéticas
March, Samanta M.
Miranda Morales, Roberto Sebastián
Alcohol-related problems: neurobiological bases of alcohol consumption and animal models developed to address these problems
topic_facet rat
alcohol
opiate system
genetic models
rata
alcohol
sistema opiáceo
bases genéticas
author March, Samanta M.
Miranda Morales, Roberto Sebastián
author_facet March, Samanta M.
Miranda Morales, Roberto Sebastián
author_sort March, Samanta M.
title Alcohol-related problems: neurobiological bases of alcohol consumption and animal models developed to address these problems
title_short Alcohol-related problems: neurobiological bases of alcohol consumption and animal models developed to address these problems
title_full Alcohol-related problems: neurobiological bases of alcohol consumption and animal models developed to address these problems
title_fullStr Alcohol-related problems: neurobiological bases of alcohol consumption and animal models developed to address these problems
title_full_unstemmed Alcohol-related problems: neurobiological bases of alcohol consumption and animal models developed to address these problems
title_sort alcohol-related problems: neurobiological bases of alcohol consumption and animal models developed to address these problems
description The present review is focused on animal models for the study of alcohol use, abuse and dependence. These models have helped to understand several features of alcohol consumption, ranging from genetic influences to environmental factors such us early experiences with the drug. Additionally, animal models have been useful tools to assess the efficacy of pharmacological treatments as well as alcohol associated phenomena, such as craving, tolerance and reinstatement. First we introduce a short description of the neurobiological basis of alcohol reinforcement, focused on the opiate system. Then we cover several animal models, from genetic models, and models focused on the study of alcohol related disorders to animal models that emphasize the importance of early experiences with the drug in the development of alcohol use and alcohol related disorders.
publisher Universidad Nacional de Córdoba
publishDate 2009
url https://revistas.unc.edu.ar/index.php/racc/article/view/5302
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AT mirandamoralesrobertosebastian alcoholrelatedproblemsneurobiologicalbasesofalcoholconsumptionandanimalmodelsdevelopedtoaddresstheseproblems
AT marchsamantam problemasrelacionadosalalcoholbasesneurobiologicasdelconsumodealcoholymodelosanimalesdesarrolladosparaelabordajedeestasproblematicas
AT mirandamoralesrobertosebastian problemasrelacionadosalalcoholbasesneurobiologicasdelconsumodealcoholymodelosanimalesdesarrolladosparaelabordajedeestasproblematicas
first_indexed 2024-09-03T22:32:03Z
last_indexed 2024-09-03T22:32:03Z
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