A review on the pathophysiology of temporal lobe epilepsy: from neuroplasticity to neuronal death

This review is focused and tries to introduce the reader in the basic concepts of the epilepsy, specially of the temporal lobe epilepsy. From the knowledge provided by different animal models, it’s introduced to the physiopathology of this type of epilepsy recognizing the participation of two system...

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Detalles Bibliográficos
Autor principal: Pereno, Germán Leandro
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional de Córdoba 2010
Materias:
animals models
temporal lobe epilepsy
hippocampus
amygdala
modelos animales
epilepsia del lóbulo temporal
hipocampo
amígdala
Acceso en línea:https://revistas.unc.edu.ar/index.php/racc/article/view/5269
Aporte de:
Revista Argentina de Ciencias del Comportamiento de Universidad Nacional de Córdoba
id I10-R363-article-5269
record_format ojs
spelling I10-R363-article-52692024-09-03T22:30:27Z A review on the pathophysiology of temporal lobe epilepsy: from neuroplasticity to neuronal death Fisiopatología de la epilepsia del lóbulo temporal: revisión del proceso de muerte neuronal a la neuroplasticidad Pereno, Germán Leandro animals models temporal lobe epilepsy hippocampus amygdala modelos animales epilepsia del lóbulo temporal hipocampo amígdala This review is focused and tries to introduce the reader in the basic concepts of the epilepsy, specially of the temporal lobe epilepsy. From the knowledge provided by different animal models, it’s introduced to the physiopathology of this type of epilepsy recognizing the participation of two systems of neurotransmition: the gabaergic and glutamatergic. It is known that an excess of glutamate has as a consequence neuronal death, this is the excitotoxicity. It’s enumerated different reports that, although they sometimes proved contradictory results, the majority find neuronal death in areas of the limbic system after a status epilepticus in experimental animals. Finally, since the brain is not immutable to this death, the principal concepts of the neuroplasticidad are review, providing reports that demonstrate that plastic processes happen in epileptic brains, both in the hippocampus and in the amygdala. El presente trabajo de revisión, está orientado y pretende introducir al lector a los conceptos básicos de la epilepsia, especialmente la epilepsia del lóbulo temporal. Partiendo del conocimiento provisto por diferentes modelos animales, se introduce la fisiopatología de este tipo de epilepsia reconociendo la participación de dos sistemas de neurotransmisión: el gabaérgico y glutamatérgico. Es conocido que el exceso de glutamato tiene como consecuencia la muerte neuronal: la excitotoxicidad. Se enumeran diferentes investigaciones que, a pesar de mostrar, a veces resultados contradictorios, la mayoría de ellas encuentran muerte neuronal en áreas del sistema límbico luego de un estado epiléptico en animales de experimentación. Finalmente, como el cerebro no es inmutable a esta muerte, se revisan los principales conceptos de neuroplasticidad, seleccionando investigaciones que demuestran los procesos plásticos que ocurren en cerebros epilépticos, tanto en el hipocampo como en la amígdala. Universidad Nacional de Córdoba 2010-02-20 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/racc/article/view/5269 10.32348/1852.4206.v2.n1.5269 Argentinean Journal of Behavioral Sciences; Vol 2, No 1 (2010): Revista Argentina de Ciencias del Comportamiento; 46-57 Revista Argentina de Ciencias del Comportamiento; Vol 2, No 1 (2010): Revista Argentina de Ciencias del Comportamiento; 46-57 1852-4206 10.32348/1852.4206.v2.n1 spa https://revistas.unc.edu.ar/index.php/racc/article/view/5269/5432 Derechos de autor 2010 Germán Leandro Pereno
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-363
container_title_str Revista Argentina de Ciencias del Comportamiento
language Español
format Artículo revista
topic animals models
temporal lobe epilepsy
hippocampus
amygdala
modelos animales
epilepsia del lóbulo temporal
hipocampo
amígdala
spellingShingle animals models
temporal lobe epilepsy
hippocampus
amygdala
modelos animales
epilepsia del lóbulo temporal
hipocampo
amígdala
Pereno, Germán Leandro
A review on the pathophysiology of temporal lobe epilepsy: from neuroplasticity to neuronal death
topic_facet animals models
temporal lobe epilepsy
hippocampus
amygdala
modelos animales
epilepsia del lóbulo temporal
hipocampo
amígdala
author Pereno, Germán Leandro
author_facet Pereno, Germán Leandro
author_sort Pereno, Germán Leandro
title A review on the pathophysiology of temporal lobe epilepsy: from neuroplasticity to neuronal death
title_short A review on the pathophysiology of temporal lobe epilepsy: from neuroplasticity to neuronal death
title_full A review on the pathophysiology of temporal lobe epilepsy: from neuroplasticity to neuronal death
title_fullStr A review on the pathophysiology of temporal lobe epilepsy: from neuroplasticity to neuronal death
title_full_unstemmed A review on the pathophysiology of temporal lobe epilepsy: from neuroplasticity to neuronal death
title_sort review on the pathophysiology of temporal lobe epilepsy: from neuroplasticity to neuronal death
description This review is focused and tries to introduce the reader in the basic concepts of the epilepsy, specially of the temporal lobe epilepsy. From the knowledge provided by different animal models, it’s introduced to the physiopathology of this type of epilepsy recognizing the participation of two systems of neurotransmition: the gabaergic and glutamatergic. It is known that an excess of glutamate has as a consequence neuronal death, this is the excitotoxicity. It’s enumerated different reports that, although they sometimes proved contradictory results, the majority find neuronal death in areas of the limbic system after a status epilepticus in experimental animals. Finally, since the brain is not immutable to this death, the principal concepts of the neuroplasticidad are review, providing reports that demonstrate that plastic processes happen in epileptic brains, both in the hippocampus and in the amygdala.
publisher Universidad Nacional de Córdoba
publishDate 2010
url https://revistas.unc.edu.ar/index.php/racc/article/view/5269
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AT perenogermanleandro reviewonthepathophysiologyoftemporallobeepilepsyfromneuroplasticitytoneuronaldeath
first_indexed 2024-09-03T22:32:00Z
last_indexed 2024-09-03T22:32:00Z
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