Molecular epidemiology pattern of hepatitis C virus infection in central region of Argentina

The presence of HCV RNA and genotype distribution among 310 samples from Central region of Argentina was detected by molecular techniques (RT-nested PCR and RFLP). HCV/HIV coinfection was 11,8% and genotype 1 was more prevalent (73%) in this group. Among HCV monoinfected individuals the prevalence o...

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Autores principales: Ré, Viviana E., Farías, Adrián A., Díaz, María P., Pisano, María B., Mengarelli, Silvia, Kremer, Luis, Elbarcha, Osvaldo, Contiagiani, Marta
Formato: Artículo revista
Lenguaje:Español
Publicado: Escuela de Salud Pública y Ambiente. Fac. Cs. Médicas UNC 2014
Materias:
Virus de la hepatitis C (HCV)
genotipos
epidemiología molecular
coinfección HCV/HIV
Argentina
Acceso en línea:https://revistas.unc.edu.ar/index.php/RSD/article/view/7122
Aporte de:
Revista de Salud Pública de Universidad Nacional de Córdoba
id I10-R360-article-7122
record_format ojs
spelling I10-R360-article-71222025-04-03T12:07:23Z Molecular epidemiology pattern of hepatitis C virus infection in central region of Argentina Perfil epidemiológico molecular de la infección por el virus de la Hepatitis C en la región central de Argentina Ré, Viviana E. Farías, Adrián A. Díaz, María P. Pisano, María B. Mengarelli, Silvia Kremer, Luis Elbarcha, Osvaldo Contiagiani, Marta Virus de la hepatitis C (HCV) genotipos epidemiología molecular coinfección HCV/HIV Argentina The presence of HCV RNA and genotype distribution among 310 samples from Central region of Argentina was detected by molecular techniques (RT-nested PCR and RFLP). HCV/HIV coinfection was 11,8% and genotype 1 was more prevalent (73%) in this group. Among HCV monoinfected individuals the prevalence of genotypes 1 and 2 were 49.4% and 43,9%, respectively.Logistic regression analysis showed that age and intravenous drug use (IVDU) are independent determinants of genotype distribution. Genotype 2 had higher prevalence in people older than 50 years, but not association with routes of transmission could be found. The prevalence of genotype 1 was due to the use IVDU among young adults. The increasing prevalence of genotype 1, homogeneously distributed in all ages has important implications in therapeutic decisions, considering its low response to antiviral therapy. La presencia de RNA-HCV y la distribución de genotipos se detectaron mediante técnicas moleculares (RT-nested PCR y RFLP) en 310 muestras de individuos de la región centro de Argentina. Se halló 11,8% de coinfección HCV/HIV, con mayor prevalencia de genotipo 1 (73%). La distribución de los genotipos 1 y 2 entre individuos monoinfectados fue de 49,4% y 43,9%, respectivamente. El análisis de regresión logística multivariado mostró que la edad y el uso de drogas endovenosas (UDEV) condicionó la distribución de genotipos. El genotipo 2 se halló frecuentemente entre adultos mayores y su diseminación no se pudo asociar a ninguna vía de transmisión. El genotipo 1 se lo halló principalmente en adultos jóvenes y asociados al UDEV. El notable incremento de genotipo 1, homogéneamente distribuido en todas las edades posee importantes implicancias en las decisiones terapéuticas, considerando que posee baja respuesta a la terapia antiviral. Escuela de Salud Pública y Ambiente. Fac. Cs. Médicas UNC 2014-04-07 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/RSD/article/view/7122 10.31052/1853.1180.v13.n2.7122 Revista de Salud Pública; Vol. 13 Núm. 2 (2009); 15-21 1852-9429 1853-1180 10.31052/1853.1180.v13.n2 spa https://revistas.unc.edu.ar/index.php/RSD/article/view/7122/8195 Derechos de autor 1969 Universidad Nacional de Córdoba https://creativecommons.org/licenses/by-nc/4.0
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-360
container_title_str Revista de Salud Pública
language Español
format Artículo revista
topic Virus de la hepatitis C (HCV)
genotipos
epidemiología molecular
coinfección HCV/HIV
Argentina
spellingShingle Virus de la hepatitis C (HCV)
genotipos
epidemiología molecular
coinfección HCV/HIV
Argentina
Ré, Viviana E.
Farías, Adrián A.
Díaz, María P.
Pisano, María B.
Mengarelli, Silvia
Kremer, Luis
Elbarcha, Osvaldo
Contiagiani, Marta
Molecular epidemiology pattern of hepatitis C virus infection in central region of Argentina
topic_facet Virus de la hepatitis C (HCV)
genotipos
epidemiología molecular
coinfección HCV/HIV
Argentina
author Ré, Viviana E.
Farías, Adrián A.
Díaz, María P.
Pisano, María B.
Mengarelli, Silvia
Kremer, Luis
Elbarcha, Osvaldo
Contiagiani, Marta
author_facet Ré, Viviana E.
Farías, Adrián A.
Díaz, María P.
Pisano, María B.
Mengarelli, Silvia
Kremer, Luis
Elbarcha, Osvaldo
Contiagiani, Marta
author_sort Ré, Viviana E.
title Molecular epidemiology pattern of hepatitis C virus infection in central region of Argentina
title_short Molecular epidemiology pattern of hepatitis C virus infection in central region of Argentina
title_full Molecular epidemiology pattern of hepatitis C virus infection in central region of Argentina
title_fullStr Molecular epidemiology pattern of hepatitis C virus infection in central region of Argentina
title_full_unstemmed Molecular epidemiology pattern of hepatitis C virus infection in central region of Argentina
title_sort molecular epidemiology pattern of hepatitis c virus infection in central region of argentina
description The presence of HCV RNA and genotype distribution among 310 samples from Central region of Argentina was detected by molecular techniques (RT-nested PCR and RFLP). HCV/HIV coinfection was 11,8% and genotype 1 was more prevalent (73%) in this group. Among HCV monoinfected individuals the prevalence of genotypes 1 and 2 were 49.4% and 43,9%, respectively.Logistic regression analysis showed that age and intravenous drug use (IVDU) are independent determinants of genotype distribution. Genotype 2 had higher prevalence in people older than 50 years, but not association with routes of transmission could be found. The prevalence of genotype 1 was due to the use IVDU among young adults. The increasing prevalence of genotype 1, homogeneously distributed in all ages has important implications in therapeutic decisions, considering its low response to antiviral therapy.
publisher Escuela de Salud Pública y Ambiente. Fac. Cs. Médicas UNC
publishDate 2014
url https://revistas.unc.edu.ar/index.php/RSD/article/view/7122
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last_indexed 2025-05-10T05:20:43Z
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