Review of the Discussion Surrounding the Incorporation of Sex as a Biological Variable (SABV) in Preclinical Research
The examination of sex as a biological variable (SABV) in preclinical research presents unique challenges and has gained significant prominence over the past decade. This article critically examines the ongoing debates surrounding the incorporation of SABV, emphasizing the limitations of the current...
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| Autores principales: | , , , , , , |
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| Formato: | Artículo revista |
| Lenguaje: | Español |
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Centro de Investigaciones de la Facultad de Filosofía y Humanidades
2025
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/afjor/article/view/46051 |
| Aporte de: |
| Sumario: | The examination of sex as a biological variable (SABV) in preclinical research presents unique challenges and has gained significant prominence over the past decade. This article critically examines the ongoing debates surrounding the incorporation of SABV, emphasizing the limitations of the current binary framework that restricts the understanding of sex to a simplistic, a priori classification of male and female. Such an approach perpetuates an essentialist perspective of sexual difference, potentially resulting in biased research outcomes and inadequate medical treatments. We advocate for a contextualist perspective, aligning with Richardson's (2022) concept of “sex contextualism,” which interprets sex as a set of variable biological characteristics across multiple biological levels and experimental contexts. We argue that this approach enhances the precision and relevance of scientific findings, and provides a more accurate representation of the biological and social diversity of the human population. This paper provides specific examples and advocates for a more inclusive and equitable methodology in integrating sex into preclinical research. |
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