Review of the Discussion Surrounding the Incorporation of Sex as a Biological Variable (SABV) in Preclinical Research

The examination of sex as a biological variable (SABV) in preclinical research presents unique challenges and has gained significant prominence over the past decade. This article critically examines the ongoing debates surrounding the incorporation of SABV, emphasizing the limitations of the current...

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Autores principales: Suárez Tomé, Danila, Goris, Veronica, Mileo, Agostina, Belli, Laura Florencia, Cano Colazo, María Victoria, Shokida , Natsumi S., Labombarda, Florencia
Formato: Artículo revista
Lenguaje:Español
Publicado: Centro de Investigaciones de la Facultad de Filosofía y Humanidades 2025
Materias:
Sexo como variable biológica (SABV)
Contextualismo sexual
Diversidad sexual
Investigación preclínica
Epistemología feminista de la ciencia
Sex as a biological variable (SABV)
Sex contextualism
Sexual diversity
Preclinical research
Feminist epistemology of science
Acceso en línea:https://revistas.unc.edu.ar/index.php/afjor/article/view/46051
Aporte de:
Epistemología e Historia de la Ciencia de Universidad Nacional de Córdoba
id I10-R341-article-46051
record_format ojs
spelling I10-R341-article-460512025-12-31T23:20:05Z Review of the Discussion Surrounding the Incorporation of Sex as a Biological Variable (SABV) in Preclinical Research Revisión de la discusión en torno a la incorporación del sexo como variable biológica (SABV) en investigación preclínica Suárez Tomé, Danila Goris, Veronica Mileo, Agostina Belli, Laura Florencia Cano Colazo, María Victoria Shokida , Natsumi S. Labombarda, Florencia Sexo como variable biológica (SABV) Contextualismo sexual Diversidad sexual Investigación preclínica Epistemología feminista de la ciencia Sex as a biological variable (SABV) Sex contextualism Sexual diversity Preclinical research Feminist epistemology of science The examination of sex as a biological variable (SABV) in preclinical research presents unique challenges and has gained significant prominence over the past decade. This article critically examines the ongoing debates surrounding the incorporation of SABV, emphasizing the limitations of the current binary framework that restricts the understanding of sex to a simplistic, a priori classification of male and female. Such an approach perpetuates an essentialist perspective of sexual difference, potentially resulting in biased research outcomes and inadequate medical treatments. We advocate for a contextualist perspective, aligning with Richardson's (2022) concept of “sex contextualism,” which interprets sex as a set of variable biological characteristics across multiple biological levels and experimental contexts. We argue that this approach enhances the precision and relevance of scientific findings, and provides a more accurate representation of the biological and social diversity of the human population. This paper provides specific examples and advocates for a more inclusive and equitable methodology in integrating sex into preclinical research. El análisis del sexo como variable biológica (Sex as a Biological Variable, SABV) en la investigación preclínica ha cobrado creciente relevancia en la última década, planteando desafíos únicos. Este artículo revisa los debates sobre la inclusión del SABV destacando los problemas del enfoque binario actual que limita la comprensión del sexo a una clasificación simplista y a apriori de masculino (male) y femenino (female). Este enfoque perpetúa una visión esencialista de la diferencia sexual que puede llevar a resultados de investigación sesgados y tratamientos médicos inadecuados. Proponemos un enfoque contextualista, siguiendo la propuesta del “contextualismo sexual” de Richardson (2022), que considera el sexo como un conjunto de características biológicas variables en múltiples niveles biológicos y contextos experimentales. Argumentamos que este enfoque puede mejorar la precisión y relevancia de los resultados científicos, reflejando mejor la diversidad biológica y social de la población humana. Este artículo presenta ejemplos particulares y propone un enfoque más inclusivo y equitativo para la inclusión del sexo en la investigación preclínica. Centro de Investigaciones de la Facultad de Filosofía y Humanidades 2025-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf text/html https://revistas.unc.edu.ar/index.php/afjor/article/view/46051 10.61377/ehc.46051 Epistemología e Historia de la Ciencia; Vol. 9 No. 1 (2025); 28-45 Epistemología e Historia de la Ciencia; Vol. 9 Núm. 1 (2025); 28-45 Epistemología e Historia de la Ciencia; v. 9 n. 1 (2025); 28-45 2525-1198 10.61377/ehc.20259.1 spa https://revistas.unc.edu.ar/index.php/afjor/article/view/46051/52068 https://revistas.unc.edu.ar/index.php/afjor/article/view/46051/52069 Derechos de autor 2025 Danila Suárez Tomé, Veronica Goris, Agostina Mileo, Laura Florencia Belli, María Victoria Cano Colazo, Natsumi S. Shokida , Florencia Labombarda https://creativecommons.org/licenses/by-nc-nd/4.0
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-341
container_title_str Epistemología e Historia de la Ciencia
language Español
format Artículo revista
topic Sexo como variable biológica (SABV)
Contextualismo sexual
Diversidad sexual
Investigación preclínica
Epistemología feminista de la ciencia
Sex as a biological variable (SABV)
Sex contextualism
Sexual diversity
Preclinical research
Feminist epistemology of science
spellingShingle Sexo como variable biológica (SABV)
Contextualismo sexual
Diversidad sexual
Investigación preclínica
Epistemología feminista de la ciencia
Sex as a biological variable (SABV)
Sex contextualism
Sexual diversity
Preclinical research
Feminist epistemology of science
Suárez Tomé, Danila
Goris, Veronica
Mileo, Agostina
Belli, Laura Florencia
Cano Colazo, María Victoria
Shokida , Natsumi S.
Labombarda, Florencia
Review of the Discussion Surrounding the Incorporation of Sex as a Biological Variable (SABV) in Preclinical Research
topic_facet Sexo como variable biológica (SABV)
Contextualismo sexual
Diversidad sexual
Investigación preclínica
Epistemología feminista de la ciencia
Sex as a biological variable (SABV)
Sex contextualism
Sexual diversity
Preclinical research
Feminist epistemology of science
author Suárez Tomé, Danila
Goris, Veronica
Mileo, Agostina
Belli, Laura Florencia
Cano Colazo, María Victoria
Shokida , Natsumi S.
Labombarda, Florencia
author_facet Suárez Tomé, Danila
Goris, Veronica
Mileo, Agostina
Belli, Laura Florencia
Cano Colazo, María Victoria
Shokida , Natsumi S.
Labombarda, Florencia
author_sort Suárez Tomé, Danila
title Review of the Discussion Surrounding the Incorporation of Sex as a Biological Variable (SABV) in Preclinical Research
title_short Review of the Discussion Surrounding the Incorporation of Sex as a Biological Variable (SABV) in Preclinical Research
title_full Review of the Discussion Surrounding the Incorporation of Sex as a Biological Variable (SABV) in Preclinical Research
title_fullStr Review of the Discussion Surrounding the Incorporation of Sex as a Biological Variable (SABV) in Preclinical Research
title_full_unstemmed Review of the Discussion Surrounding the Incorporation of Sex as a Biological Variable (SABV) in Preclinical Research
title_sort review of the discussion surrounding the incorporation of sex as a biological variable (sabv) in preclinical research
description The examination of sex as a biological variable (SABV) in preclinical research presents unique challenges and has gained significant prominence over the past decade. This article critically examines the ongoing debates surrounding the incorporation of SABV, emphasizing the limitations of the current binary framework that restricts the understanding of sex to a simplistic, a priori classification of male and female. Such an approach perpetuates an essentialist perspective of sexual difference, potentially resulting in biased research outcomes and inadequate medical treatments. We advocate for a contextualist perspective, aligning with Richardson's (2022) concept of “sex contextualism,” which interprets sex as a set of variable biological characteristics across multiple biological levels and experimental contexts. We argue that this approach enhances the precision and relevance of scientific findings, and provides a more accurate representation of the biological and social diversity of the human population. This paper provides specific examples and advocates for a more inclusive and equitable methodology in integrating sex into preclinical research.
publisher Centro de Investigaciones de la Facultad de Filosofía y Humanidades
publishDate 2025
url https://revistas.unc.edu.ar/index.php/afjor/article/view/46051
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first_indexed 2026-02-04T19:04:19Z
last_indexed 2026-02-04T19:04:19Z
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