Study of properties and structure of gels for topical application in post-extraction tooth sockets
The process from an active ingredient to the final medicine requires pre-formulation and stability studies of the product developed under different conditions, as well as the standardization of the extract as raw material. The objective of this work was to characterize formulations for topical appli...
Guardado en:
| Autores principales: | , , , |
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| Formato: | Artículo revista |
| Lenguaje: | Español |
| Publicado: |
Facultad de Odontología
2022
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| Materias: | |
| Acceso en línea: | https://revistas.unc.edu.ar/index.php/RevFacOdonto/article/view/39609 |
| Aporte de: |
| id |
I10-R335-article-39609 |
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| record_format |
ojs |
| institution |
Universidad Nacional de Córdoba |
| institution_str |
I-10 |
| repository_str |
R-335 |
| container_title_str |
Revista de la Facultad de Odontología |
| language |
Español |
| format |
Artículo revista |
| topic |
alendronate arnica montana gel characterization Alendronato Arnica montana caracterización del gel |
| spellingShingle |
alendronate arnica montana gel characterization Alendronato Arnica montana caracterización del gel Virga , María Carolina Aguzzi, Alejandra Cecilia De Leonardi, Adriana Ruth María Moro, Cecilia Study of properties and structure of gels for topical application in post-extraction tooth sockets |
| topic_facet |
alendronate arnica montana gel characterization Alendronato Arnica montana caracterización del gel |
| author |
Virga , María Carolina Aguzzi, Alejandra Cecilia De Leonardi, Adriana Ruth María Moro, Cecilia |
| author_facet |
Virga , María Carolina Aguzzi, Alejandra Cecilia De Leonardi, Adriana Ruth María Moro, Cecilia |
| author_sort |
Virga , María Carolina |
| title |
Study of properties and structure of gels for topical application in post-extraction tooth sockets |
| title_short |
Study of properties and structure of gels for topical application in post-extraction tooth sockets |
| title_full |
Study of properties and structure of gels for topical application in post-extraction tooth sockets |
| title_fullStr |
Study of properties and structure of gels for topical application in post-extraction tooth sockets |
| title_full_unstemmed |
Study of properties and structure of gels for topical application in post-extraction tooth sockets |
| title_sort |
study of properties and structure of gels for topical application in post-extraction tooth sockets |
| description |
The process from an active ingredient to the final medicine requires pre-formulation and stability studies of the product developed under different conditions, as well as the standardization of the extract as raw material. The objective of this work was to characterize formulations for topical application (gels), for use in post-extraction tooth sockets. Materials and methods: The gels were made according to good laboratory practice standards. The pH of the gel formulations was measure with a pH meter (Eutech, Cyberscan) using 1% aqueous solutions of the gels at room temperature. Extensibility was determined with a wooden block and glass slide apparatus. The gel was added and the time it took too completely separate from the fixed was note. The spreading capacity was calculate using formulas (S = W × L / T) The measurement of the consistency of the gels was carried out by dropping a cone from a fixed distance of 10 cm in such a way that it lands in the center of a glass cup filled with the gel. Cone penetration was measured from the surface of the gel to the tip of the cone within the gel. The distance traveled by the cone after 10 seconds was recorded. To analyze the superficial topographic characteristics of the gels, photographs were taken with a confocal microscope. Results: All formulations are in a range of pH values close to neutrality (pH 6.4-6.9). The gel prepared with alendronate presented higher extensibility, while the others showed lower extensibility with similarities between them. The consistency analysis showed no differences between the formulations. The selected formulations presented a brown olive-green color with different intensities; they presented a homogeneous appearance to the naked eye, but heterogeneous when observed under a confocal microscope. Conclusions: In the characterization of the gels, show that they have a variable texture and consistency depends on the type and concentration of the active ingredient used. The most suitable gel formulation was alendronate. |
| publisher |
Facultad de Odontología |
| publishDate |
2022 |
| url |
https://revistas.unc.edu.ar/index.php/RevFacOdonto/article/view/39609 |
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2024-09-03T21:16:28Z |
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2025-10-10T05:06:47Z |
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I10-R335-article-396092025-10-06T13:04:40Z Study of properties and structure of gels for topical application in post-extraction tooth sockets Estudio de propiedades y estructura de geles de aplicación tópica para uso en alvéolos dentarios postextracción Virga , María Carolina Aguzzi, Alejandra Cecilia De Leonardi, Adriana Ruth María Moro, Cecilia alendronate arnica montana gel characterization Alendronato Arnica montana caracterización del gel The process from an active ingredient to the final medicine requires pre-formulation and stability studies of the product developed under different conditions, as well as the standardization of the extract as raw material. The objective of this work was to characterize formulations for topical application (gels), for use in post-extraction tooth sockets. Materials and methods: The gels were made according to good laboratory practice standards. The pH of the gel formulations was measure with a pH meter (Eutech, Cyberscan) using 1% aqueous solutions of the gels at room temperature. Extensibility was determined with a wooden block and glass slide apparatus. The gel was added and the time it took too completely separate from the fixed was note. The spreading capacity was calculate using formulas (S = W × L / T) The measurement of the consistency of the gels was carried out by dropping a cone from a fixed distance of 10 cm in such a way that it lands in the center of a glass cup filled with the gel. Cone penetration was measured from the surface of the gel to the tip of the cone within the gel. The distance traveled by the cone after 10 seconds was recorded. To analyze the superficial topographic characteristics of the gels, photographs were taken with a confocal microscope. Results: All formulations are in a range of pH values close to neutrality (pH 6.4-6.9). The gel prepared with alendronate presented higher extensibility, while the others showed lower extensibility with similarities between them. The consistency analysis showed no differences between the formulations. The selected formulations presented a brown olive-green color with different intensities; they presented a homogeneous appearance to the naked eye, but heterogeneous when observed under a confocal microscope. Conclusions: In the characterization of the gels, show that they have a variable texture and consistency depends on the type and concentration of the active ingredient used. The most suitable gel formulation was alendronate. El proceso de un principio activo al medicamento final requiere de estudios de pre-formulación y de estabilidad del producto desarrollado en distintas condiciones, así como la estandarización del extracto. El objetivo fue caracterizar formulaciones de aplicación tópica, para uso en alvéolo postextracción dentaria. Materiales y métodos: Los geles fueron preparados según normas de buenas prácticas de laboratorio. El pH de las formulaciones se midió con medidor de pH (Eutech, Cyberscan) usando 1% soluciones a temperatura ambiente. La extensibilidad se determinó con un bloque de madera y un aparato de portaobjetos de vidrio. Se añadió el gel y se anotó el tiempo que tarda para separarse completamente del fijo. La capacidad de esparcimiento se calculó mediante fórmulas (S = W × L / T) La medición de la consistencia se llevó a cabo dejando caer un cono desde una distancia fija de 10 cm de tal manera que caiga en el centro de una taza de vidrio llena con el gel. La penetración del cono se midió desde la superficie del gel hasta la punta del cono dentro del gel. Se anotó la distancia recorrida por el cono después de 10 segundos. Para analizar las características topográficas superficiales se tomaron fotografías con microscopio confocal. Resultados: Todas las formulaciones se encuentran en un rango de valores de pH cercanos a la neutralidad (pH 6,4-6,9). La muestra con alendronato presentó mayor extensibilidad, mientras que los otros demostraron menor extensibilidad. El análisis de la consistencia no mostró diferencias entre las formulaciones. Las formulaciones presentaron un color verde oliva pardo; presentaron aspecto homogéneo a simple vista, pero heterogéneos cuando se observaron bajo microscopio confocal. Conclusiones: se pudo demostrarse que presentan una textura y consistencia variable que depende del tipo y concentración del principio activo empleado. La fórmula de gel más adecuada fue la de alendronato. Facultad de Odontología 2022-12-05 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/RevFacOdonto/article/view/39609 Revista de la Facultad de Odontología; Vol. 32 Núm. 3 (2022): Rev Fac Odont 32(3)-2022-Diciembre; 4-9 2545-7594 0325-1071 spa https://revistas.unc.edu.ar/index.php/RevFacOdonto/article/view/39609/39641 10.25014/ Derechos de autor 2022 María Carolina Virga , Alejandra Cecilia Aguzzi, Adriana Ruth María De Leonardi, Cecilia Moro https://creativecommons.org/licenses/by/4.0 |