Acinic cell carcinoma of the salivary glands: clinical and histopathological study of 12 cases
Objective: Acinic cell carcinoma (CCA) is the third malignant epithelial tumor of the salivary glands in adults; low-grade tumor of malignancy, composed of neoplastic cells with serous acinar differentiation. The objective of this work was to analyze 12 cases of CCA according to their loca...
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| Formato: | Artículo revista |
| Lenguaje: | Español |
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Facultad de Odontología
2021
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/RevFacOdonto/article/view/35947 |
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I10-R335-article-35947 |
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ojs |
| institution |
Universidad Nacional de Córdoba |
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I-10 |
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R-335 |
| container_title_str |
Revista de la Facultad de Odontología |
| language |
Español |
| format |
Artículo revista |
| topic |
salivary glands tumors acinic cell carcinoma clinic histology immunohistochemistry glándulas salivales tumores carcinoma de células acinares clínica histología inmunohistoquímica |
| spellingShingle |
salivary glands tumors acinic cell carcinoma clinic histology immunohistochemistry glándulas salivales tumores carcinoma de células acinares clínica histología inmunohistoquímica Samar, María Elena Avila, Rodolfo Esteban Ferraris, , Ricardo Virgilio García, Pedro Emilio Fonseca, Ismael Bernardo Fernández, Javier Elías Gomez Rosso, María Araceli Ferraris, Florencia Acinic cell carcinoma of the salivary glands: clinical and histopathological study of 12 cases |
| topic_facet |
salivary glands tumors acinic cell carcinoma clinic histology immunohistochemistry glándulas salivales tumores carcinoma de células acinares clínica histología inmunohistoquímica |
| author |
Samar, María Elena Avila, Rodolfo Esteban Ferraris, , Ricardo Virgilio García, Pedro Emilio Fonseca, Ismael Bernardo Fernández, Javier Elías Gomez Rosso, María Araceli Ferraris, Florencia |
| author_facet |
Samar, María Elena Avila, Rodolfo Esteban Ferraris, , Ricardo Virgilio García, Pedro Emilio Fonseca, Ismael Bernardo Fernández, Javier Elías Gomez Rosso, María Araceli Ferraris, Florencia |
| author_sort |
Samar, María Elena |
| title |
Acinic cell carcinoma of the salivary glands: clinical and histopathological study of 12 cases |
| title_short |
Acinic cell carcinoma of the salivary glands: clinical and histopathological study of 12 cases |
| title_full |
Acinic cell carcinoma of the salivary glands: clinical and histopathological study of 12 cases |
| title_fullStr |
Acinic cell carcinoma of the salivary glands: clinical and histopathological study of 12 cases |
| title_full_unstemmed |
Acinic cell carcinoma of the salivary glands: clinical and histopathological study of 12 cases |
| title_sort |
acinic cell carcinoma of the salivary glands: clinical and histopathological study of 12 cases |
| description |
Objective: Acinic cell carcinoma (CCA) is the third malignant epithelial tumor of the salivary glands in adults; low-grade tumor of malignancy, composed of neoplastic cells with serous acinar differentiation. The objective of this work was to analyze 12 cases of CCA according to their location, clinical characteristics, histological and immunohistochemical pattern and cell types, following the latest classification of the World Health Organization. Methods: The study included 12 cases of CCA from the files of salivary tumor biopsies of our work team, corresponding to the period 1997-2020. A numerical code was used to identify the samples, preserving the identity of the patients. Histological sections of the paraffin-embedded biopsies were evaluated with H/E, PAS and Toluidine blue and immunostained with the monoclonal antibodies pancytokeratin AE1 / AE3, Ki67, MUC-1 and mammaglobin. Results: The most frequent histologic pattern was the solid type as a single pattern or integrated with other patterns of lesser development, with almost exclusive location in the parotid gland and more frequent in women. Cells like normal acinar serocytes predominated in the solid growth pattern. The most frequent cell type in the microcystic pattern was the nonspecific glandular cell together with a lower proportion of acinar and intercalated duct-like cells. The papillary-cystic pattern was lined by nonspecific glandular cells. No clear cells found. With Ki67 a low cell proliferation was demonstrated in all the cases studied. Cell labeling for MUC-1 was grade 1 positive (less than 10% immunoreactive cells) and negative for mammaglobin. Conclusions: Patient follow-up is a priority because CCA tends to recur and metastasize and its behavior can become aggressive. We must deepen the study of its proliferative capacity as a treatment and prognosis tool, especially with immunohistochemistry and standardized molecular biology methods |
| publisher |
Facultad de Odontología |
| publishDate |
2021 |
| url |
https://revistas.unc.edu.ar/index.php/RevFacOdonto/article/view/35947 |
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2024-09-03T21:16:23Z |
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I10-R335-article-359472025-12-02T13:10:40Z Acinic cell carcinoma of the salivary glands: clinical and histopathological study of 12 cases Carcinoma de células acinares de glándulas salivales: estudio clínico e histopatológico de 12 casos Samar, María Elena Avila, Rodolfo Esteban Ferraris, , Ricardo Virgilio García, Pedro Emilio Fonseca, Ismael Bernardo Fernández, Javier Elías Gomez Rosso, María Araceli Ferraris, Florencia salivary glands tumors acinic cell carcinoma clinic histology immunohistochemistry glándulas salivales tumores carcinoma de células acinares clínica histología inmunohistoquímica Objective: Acinic cell carcinoma (CCA) is the third malignant epithelial tumor of the salivary glands in adults; low-grade tumor of malignancy, composed of neoplastic cells with serous acinar differentiation. The objective of this work was to analyze 12 cases of CCA according to their location, clinical characteristics, histological and immunohistochemical pattern and cell types, following the latest classification of the World Health Organization. Methods: The study included 12 cases of CCA from the files of salivary tumor biopsies of our work team, corresponding to the period 1997-2020. A numerical code was used to identify the samples, preserving the identity of the patients. Histological sections of the paraffin-embedded biopsies were evaluated with H/E, PAS and Toluidine blue and immunostained with the monoclonal antibodies pancytokeratin AE1 / AE3, Ki67, MUC-1 and mammaglobin. Results: The most frequent histologic pattern was the solid type as a single pattern or integrated with other patterns of lesser development, with almost exclusive location in the parotid gland and more frequent in women. Cells like normal acinar serocytes predominated in the solid growth pattern. The most frequent cell type in the microcystic pattern was the nonspecific glandular cell together with a lower proportion of acinar and intercalated duct-like cells. The papillary-cystic pattern was lined by nonspecific glandular cells. No clear cells found. With Ki67 a low cell proliferation was demonstrated in all the cases studied. Cell labeling for MUC-1 was grade 1 positive (less than 10% immunoreactive cells) and negative for mammaglobin. Conclusions: Patient follow-up is a priority because CCA tends to recur and metastasize and its behavior can become aggressive. We must deepen the study of its proliferative capacity as a treatment and prognosis tool, especially with immunohistochemistry and standardized molecular biology methods Objetivo: El carcinoma de células acinares (CCA) es el tercer tumor epitelial maligno de glándulas salivales en adultos; tumor de bajo grado de malignidad, compuesto por células cancerosas con características acinares. El objetivo de este trabajo fue analizar 12 casos de CCA según su localización, características clínicas, patrón histológico, inmunohistoquímico y tipos celulares, siguiendo la última clasificación de la Organización Mundial de la Salud. Métodos: El estudio incluyó 12 casos de CCA de los archivos de biopsias de tumores salivales de nuestro equipo de trabajo, correspondientes al periodo 1997-2020. Se utilizó un código numérico para identificar las muestras, preservando la identidad de los pacientes. Cortes histológicos de las biopsias incluidas en parafina se evaluaron con H/E, PAS y Azul de toluidina e inmunomarcaron con los anticuerpos monoclonales pancitoqueratina AE1/AE3, Ki67, MUC-1/EMA y mamaglobina. Resultados: El patrón histológico más frecuente fue el tipo sólido como patrón único o integrado con otros patrones de menor desarrollo, con localización casi excluyente en glándula parótida y mayor frecuencia en mujeres. En el patrón sólido predominaron células semejantes a los serocitos acinares. El tipo celular más frecuente en el patrón microquístico fue la célula glandular no específica junto a una menor proporción de células tipo ductales intercaladas y tipo serocitos. Las estructuras quístico-papilares estaban revestidas por células glandulares no específicas. No se encontraron células claras. Con Ki67 se demostró una baja proliferación celular en todos los casos estudiados. la marcación celular para MUC-1 fue positiva grado 1 (menos del 10% de células inmunorreactivas) y negativa para mamaglobina. Conclusiones: El seguimiento de los pacientes es prioritario porque el CCA tiene tendencia a recurrir y a producir metástasis y su comportamiento puede tornarse agresivo. Debemos profundizar el estudio de su actividad proliferativa como herramienta de pronóstico y tratamiento, especialmente con inmunohistoquímica y métodos de biología molecular estandarizados Facultad de Odontología 2021-12-12 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/RevFacOdonto/article/view/35947 Revista de la Facultad de Odontología; Vol. 31 Núm. 3 (2021): Rev Fac Odont 31(3)-2021-Diciembre; 12-23 2545-7594 0325-1071 spa https://revistas.unc.edu.ar/index.php/RevFacOdonto/article/view/35947/36053 10.25014/ Derechos de autor 2021 María Elena Samar, Rodolfo Esteban Avila, Ricardo Virgilio Ferraris, , Pedro Emilio García, Ismael Bernardo Fonseca, Javier Elías Fernández, María Araceli Gomez Rosso, Florencia Ferraris https://creativecommons.org/licenses/by/4.0 |