Polymorphonuclears in oral mucosa of celiac children not gluten free diet

Our work group first described the presence of Polymorphonuclears (PMNs) in the oral mucosa smears of children patients with CD and not comply a gluten-free diet. The objective of this work was to associate the PMN in oral mucosa smears of celiac children and factors as recurrent aphthous stomatitis...

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Autores principales: Mina, S., Brunotto, M.
Formato: Artículo revista
Lenguaje:Español
Publicado: Facultad de Odontología 2018
Materias:
Celiac Disease
Leukocytes
Stomatitis
Aphthous
Enfermedad Celíaca
Leucocitos
Estomatitis Aftosa
Acceso en línea:https://revistas.unc.edu.ar/index.php/RevFacOdonto/article/view/19761
Aporte de:
Revista de la Facultad de Odontología de Universidad Nacional de Córdoba
id I10-R335-article-19761
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institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-335
container_title_str Revista de la Facultad de Odontología
language Español
format Artículo revista
topic Celiac Disease
Leukocytes
Stomatitis
Aphthous
Enfermedad Celíaca
Leucocitos
Estomatitis Aftosa
spellingShingle Celiac Disease
Leukocytes
Stomatitis
Aphthous
Enfermedad Celíaca
Leucocitos
Estomatitis Aftosa
Mina, S.
Brunotto, M.
Polymorphonuclears in oral mucosa of celiac children not gluten free diet
topic_facet Celiac Disease
Leukocytes
Stomatitis
Aphthous
Enfermedad Celíaca
Leucocitos
Estomatitis Aftosa
author Mina, S.
Brunotto, M.
author_facet Mina, S.
Brunotto, M.
author_sort Mina, S.
title Polymorphonuclears in oral mucosa of celiac children not gluten free diet
title_short Polymorphonuclears in oral mucosa of celiac children not gluten free diet
title_full Polymorphonuclears in oral mucosa of celiac children not gluten free diet
title_fullStr Polymorphonuclears in oral mucosa of celiac children not gluten free diet
title_full_unstemmed Polymorphonuclears in oral mucosa of celiac children not gluten free diet
title_sort polymorphonuclears in oral mucosa of celiac children not gluten free diet
description Our work group first described the presence of Polymorphonuclears (PMNs) in the oral mucosa smears of children patients with CD and not comply a gluten-free diet. The objective of this work was to associate the PMN in oral mucosa smears of celiac children and factors as recurrent aphthous stomatitis (RAS) or other typical signs and symptoms. To established two groups: a) celiac children (CD) (n=27); b) non celiac children (NCD) (n=24) were not affected by gastrointestinal pathology or other diseases related to CD and negative for IgA AGA, IgG AGA, total IgA, and IgA EMA. Both groups included, female/male, 4-12 years old with similar sociodemographic, cultural, and odonto-medical features. It recorder the irritable behavior, RAS and pick-up smears of non-keratinized zones of oral cavity. The association between PMN and RAS in celiac children was evaluated by logistic model and bivariate relations by Fisher test. For all test the statistical significance was set p<0.05. RAS were observed in a significantly higher percentage (p=0.0007) in CD children (55.6%) compared to NCD (8.3%), while PMNs were only observed in CD children (44.4%; p=0.0002). Also, 70.4% of children with CD exhibited anxiety state in comparison to 12.5% of NCD children (p=0.0001). A strongly significant association was observed between the presence of RAS and its lesions and PMNs in smears of CD. Our results showed an association between PMNs and RAS in CD children, probably due to anxiety and/or stress states in children having CD. It could be said that in CD patients not complying with a gluten free diet, PMNs and other specific markers could be used as markers of a presumptive diagnosis; also, in patients with a confirmed diagnosis, they could signal the fulfillment of a diet together with other signs and symptoms.
publisher Facultad de Odontología
publishDate 2018
url https://revistas.unc.edu.ar/index.php/RevFacOdonto/article/view/19761
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AT brunottom polimorfonuclearesenmucosaoraldeninosceliacossindietalibredegluten
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last_indexed 2024-09-03T21:15:08Z
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spelling I10-R335-article-197612018-12-12T13:04:21Z Polymorphonuclears in oral mucosa of celiac children not gluten free diet Polimorfo-nucleares en mucosa oral de niños celíacos sin dieta libre de gluten Mina, S. Brunotto, M. Celiac Disease Leukocytes Stomatitis Aphthous Enfermedad Celíaca Leucocitos Estomatitis Aftosa Our work group first described the presence of Polymorphonuclears (PMNs) in the oral mucosa smears of children patients with CD and not comply a gluten-free diet. The objective of this work was to associate the PMN in oral mucosa smears of celiac children and factors as recurrent aphthous stomatitis (RAS) or other typical signs and symptoms. To established two groups: a) celiac children (CD) (n=27); b) non celiac children (NCD) (n=24) were not affected by gastrointestinal pathology or other diseases related to CD and negative for IgA AGA, IgG AGA, total IgA, and IgA EMA. Both groups included, female/male, 4-12 years old with similar sociodemographic, cultural, and odonto-medical features. It recorder the irritable behavior, RAS and pick-up smears of non-keratinized zones of oral cavity. The association between PMN and RAS in celiac children was evaluated by logistic model and bivariate relations by Fisher test. For all test the statistical significance was set p<0.05. RAS were observed in a significantly higher percentage (p=0.0007) in CD children (55.6%) compared to NCD (8.3%), while PMNs were only observed in CD children (44.4%; p=0.0002). Also, 70.4% of children with CD exhibited anxiety state in comparison to 12.5% of NCD children (p=0.0001). A strongly significant association was observed between the presence of RAS and its lesions and PMNs in smears of CD. Our results showed an association between PMNs and RAS in CD children, probably due to anxiety and/or stress states in children having CD. It could be said that in CD patients not complying with a gluten free diet, PMNs and other specific markers could be used as markers of a presumptive diagnosis; also, in patients with a confirmed diagnosis, they could signal the fulfillment of a diet together with other signs and symptoms. Nuestro grupo de trabajo describió por primera vez la presencia de polimorfonucleares (PMN) en los frotis de mucosa oral en pacientes pediátricos con Enfermedad Celíaca (EC) y que no cumplían con una dieta libre de gluten. El objetivo de este trabajo fue asociar los PMN presentes en frotis de mucosa oral de niños celíacos con factores como la estomatitis aftosa recurrente (EAR) u otros signos y síntomas típicos de EC. Se establecieron dos grupos: a) niños celíacos (EC) (n=27); b) niños no celíacos (NEC) (n=24), estos últimos que presentaran patología gastrointestinal u otras enfermedades relacionadas con EC y negativos para IgA AGA, IgG AGA, IgA total e IgA EMA. Ambos grupos incluyeron, niños y niñas, de 4 a 12 años con características socio-demográficas, culturales y odonto-médicas similares. Se registró el comportamiento irritable, EAR y muestras de zonas no queratinizadas de la cavidad oral. La asociación entre PMN y EAR en niños celíacos se evaluó mediante modelo logístico y relaciones bivariadas, prueba de Fisher. Para todas las pruebas, la significación estadística se estableció p<0,05. Se observaron EAR en un porcentaje significativamente mayor (p=0,0007) en niños con EC (55,6%) en comparación con NEC (8,3%), mientras que los PMN solo se observaron en niños con EC (44,4%; p = 0,0002). Además, el 70.4% de los niños con EC exhibieron estado de ansiedad en comparación con el 12.5% de los niños con NEC (p=0.0001). Se observó una asociación fuertemente significativa entre la presencia de EAR y los PMN en frotis de EC. Nuestros resultados mostraron una asociación entre PMN y EAR en niños con EC, probablemente debido a estados de ansiedad y / o estrés en niños con EC. Podría decirse que en pacientes con EC que no cumplen con una dieta libre de gluten, los PMN y otros marcadores específicos podrían ser útiles como biomarcadores de un diagnóstico presuntivo; Además, en pacientes con un diagnóstico confirmado, podrían indicar, junto con otros signos y síntomas típicos de EC, el cumplimiento de la dieta libre de gluten. Facultad de Odontología 2018-03-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/RevFacOdonto/article/view/19761 Revista de la Facultad de Odontología; Vol. 28 Núm. 1 (2018); 42-48 2545-7594 0325-1071 spa https://revistas.unc.edu.ar/index.php/RevFacOdonto/article/view/19761/19513 10.25014/RevFacOdont27166

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