Age-related macular degeneration: importance of the use of animals models for the study of its pathogenesis and potential therapeutic agents
Age-related macular degeneration (AMD) is a multifactorial pathology where macula, high photoreceptor region of the retina, suffers a degeneration causing loss of central vision. AMD is a chronic disease that mainly affects adults over 65 years old. Its pathogenic mechanisms are unknown plenty, ther...
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Facultad de Ciencias Químicas
2022
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/Bitacora/article/view/37277 |
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I10-R332-article-372772022-04-18T10:48:33Z Age-related macular degeneration: importance of the use of animals models for the study of its pathogenesis and potential therapeutic agents Degeneración Macular Asociada a la Edad: importancia del uso de modelos animales para el estudio de su patogénesis y potenciales agentes terapéuticos Tovo, Albana Costantini, Daniela I. Subirada, Paula V. Barcelona, Pablo F. Degeneración macular asociada a la edad, Modelos Animales, Neovascularización, Coroides, Retina. Age-related macular degeneration (AMD) is a multifactorial pathology where macula, high photoreceptor region of the retina, suffers a degeneration causing loss of central vision. AMD is a chronic disease that mainly affects adults over 65 years old. Its pathogenic mechanisms are unknown plenty, therefore it is important to deepen the study of its pathogenic mechanisms in order to develop new therapeutic agents. In this sense, experimental animals are a valuable tool since they offer us the possibility of studyingmultiple processes during the pathology. Among the various species currently used, rodents widely stand out, although none of them allow to fully reproduce the stages of the Bitácora digital / Facultad de Ciencias Químicas (UNC) І2 pathology as it occurs in humans. In this review, we will try to expose the virtues and limitations of the different animal models available today, to improve the understanding of the mechanisms of AMD as well as their application in the development of new therapeutic strategies for its prevention and treatment. La degeneración macular asociada a la edad (DMAE) es una patología multifactorial donde se produce la degeneración de la macula, región de la retina de mayor densidad de fotorreceptores, la cual genera la pérdida de la visión central. La DMAE es una enfermedadcrónica, que afecta mayoritariamente a adultos mayores de 65 años. Sus mecanismos patogénicos no son conocidos en su totalidad, por esa razón profundizar su estudio es fundamental para el desarrollo de nuevos agentes terapéuticos. En este sentido, losanimales de experimentación son una herramienta valiosa ya que nos ofrecen la posibilidad de estudiar múltiples procesos que se llevan a cabo durante esta patología.Entre las diversas especies actualmente utilizadas, se destacan ampliamente los roedores, aunque ninguna de ellas logra reproducir en su totalidad las etapas de la patología tal y como ocurre en los seres humanos. En esta revisión, intentaremos exponer las virtudes y limitaciones de los diferentes modelos animales disponibles en la actualidad, para mejorarel entendimiento de los mecanismos de la DMAE así como para aplicar en el desarrollo de nuevas estrategias terapéuticas para su prevención y tratamiento. Facultad de Ciencias Químicas 2022-04-18 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/Bitacora/article/view/37277 Bitácora Digital; Vol. 8 Núm. 12 (2021): Bitacora Digital 2344-9144 spa https://revistas.unc.edu.ar/index.php/Bitacora/article/view/37277/37457 |
| institution |
Universidad Nacional de Córdoba |
| institution_str |
I-10 |
| repository_str |
R-332 |
| container_title_str |
Bitácora Digital |
| language |
Español |
| format |
Artículo revista |
| topic |
Degeneración macular asociada a la edad, Modelos Animales, Neovascularización, Coroides, Retina. |
| spellingShingle |
Degeneración macular asociada a la edad, Modelos Animales, Neovascularización, Coroides, Retina. Tovo, Albana Costantini, Daniela I. Subirada, Paula V. Barcelona, Pablo F. Age-related macular degeneration: importance of the use of animals models for the study of its pathogenesis and potential therapeutic agents |
| topic_facet |
Degeneración macular asociada a la edad, Modelos Animales, Neovascularización, Coroides, Retina. |
| author |
Tovo, Albana Costantini, Daniela I. Subirada, Paula V. Barcelona, Pablo F. |
| author_facet |
Tovo, Albana Costantini, Daniela I. Subirada, Paula V. Barcelona, Pablo F. |
| author_sort |
Tovo, Albana |
| title |
Age-related macular degeneration: importance of the use of animals models for the study of its pathogenesis and potential therapeutic agents |
| title_short |
Age-related macular degeneration: importance of the use of animals models for the study of its pathogenesis and potential therapeutic agents |
| title_full |
Age-related macular degeneration: importance of the use of animals models for the study of its pathogenesis and potential therapeutic agents |
| title_fullStr |
Age-related macular degeneration: importance of the use of animals models for the study of its pathogenesis and potential therapeutic agents |
| title_full_unstemmed |
Age-related macular degeneration: importance of the use of animals models for the study of its pathogenesis and potential therapeutic agents |
| title_sort |
age-related macular degeneration: importance of the use of animals models for the study of its pathogenesis and potential therapeutic agents |
| description |
Age-related macular degeneration (AMD) is a multifactorial pathology where macula, high photoreceptor region of the retina, suffers a degeneration causing loss of central vision. AMD is a chronic disease that mainly affects adults over 65 years old. Its pathogenic mechanisms are unknown plenty, therefore it is important to deepen the study of its pathogenic mechanisms in order to develop new therapeutic agents. In this sense, experimental animals are a valuable tool since they offer us the possibility of studyingmultiple processes during the pathology. Among the various species currently used, rodents widely stand out, although none of them allow to fully reproduce the stages of the Bitácora digital / Facultad de Ciencias Químicas (UNC) І2 pathology as it occurs in humans. In this review, we will try to expose the virtues and limitations of the different animal models available today, to improve the understanding of the mechanisms of AMD as well as their application in the development of new therapeutic strategies for its prevention and treatment. |
| publisher |
Facultad de Ciencias Químicas |
| publishDate |
2022 |
| url |
https://revistas.unc.edu.ar/index.php/Bitacora/article/view/37277 |
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2024-09-03T21:08:19Z |
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2024-09-03T21:08:19Z |
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