Linfoma cutáneo de la zona marginal
Primary cutaneous marginal zone B-cell lymphoma is an indolent lymphoid neoplasm originating in post-germinal B lymphocytes of the extranodal mucosa-associated lymphoid tissue (MALT) of the skin. Its frequency is 7% to 9% of all primary cutaneous lymphomas. It is associated with chronic inflammatory...
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2025
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/50432 |
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I10-R327-article-50432 |
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Universidad Nacional de Córdoba |
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R-327 |
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Revista de la Facultad de Ciencias Médicas de Córdoba |
| language |
Español |
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Artículo revista |
| topic |
linfoma de Células B de la Zona Marginal linfoma MALT linfoma cutaneo linfoma de Células B de la Zona Marginal linfoma MALT linfoma cutaneo marginal zone B-cell lymphoma MALT lymphoma cutaneous lymphoma |
| spellingShingle |
linfoma de Células B de la Zona Marginal linfoma MALT linfoma cutaneo linfoma de Células B de la Zona Marginal linfoma MALT linfoma cutaneo marginal zone B-cell lymphoma MALT lymphoma cutaneous lymphoma Valenzuela, S Moyano Crespo, GD Matsuzaki, M Rufino, R Silva, I Caggia, A Valenzuela, S Moyano Crespo, GD Matsuzaki, M Rufino, R Silva, I Caggia, A Valenzuela, S Moyano Crespo, GD Matsuzaki, M Rufino, R Silva, I Caggia, A Linfoma cutáneo de la zona marginal |
| topic_facet |
linfoma de Células B de la Zona Marginal linfoma MALT linfoma cutaneo linfoma de Células B de la Zona Marginal linfoma MALT linfoma cutaneo marginal zone B-cell lymphoma MALT lymphoma cutaneous lymphoma |
| author |
Valenzuela, S Moyano Crespo, GD Matsuzaki, M Rufino, R Silva, I Caggia, A Valenzuela, S Moyano Crespo, GD Matsuzaki, M Rufino, R Silva, I Caggia, A Valenzuela, S Moyano Crespo, GD Matsuzaki, M Rufino, R Silva, I Caggia, A |
| author_facet |
Valenzuela, S Moyano Crespo, GD Matsuzaki, M Rufino, R Silva, I Caggia, A Valenzuela, S Moyano Crespo, GD Matsuzaki, M Rufino, R Silva, I Caggia, A Valenzuela, S Moyano Crespo, GD Matsuzaki, M Rufino, R Silva, I Caggia, A |
| author_sort |
Valenzuela, S |
| title |
Linfoma cutáneo de la zona marginal |
| title_short |
Linfoma cutáneo de la zona marginal |
| title_full |
Linfoma cutáneo de la zona marginal |
| title_fullStr |
Linfoma cutáneo de la zona marginal |
| title_full_unstemmed |
Linfoma cutáneo de la zona marginal |
| title_sort |
linfoma cutáneo de la zona marginal |
| description |
Primary cutaneous marginal zone B-cell lymphoma is an indolent lymphoid neoplasm originating in post-germinal B lymphocytes of the extranodal mucosa-associated lymphoid tissue (MALT) of the skin. Its frequency is 7% to 9% of all primary cutaneous lymphomas. It is associated with chronic inflammatory and autoimmune processes. There are four histopathological variants: conventional, lymphoplasmacytic, plasmacytic, and blastoid. Conventional is the most common. It generally affects young adults, often men, and presents as reddish-brown papules, plaques, or nodules on the upper extremities or torso. These can be solitary or multiple. The histomorphology presents a characteristic triad: reactive lymphoid follicles, diffuse infiltration of small lymphocytes, and lymphoepithelial lesions with a morphology similar to Peyer's patches. The conventional variant has an excellent prognosis, with an estimated 5-year survival rate of 98%. Recurrences can occur in 40–50% of patients. The objective is to report an unusual variant of cutaneous lymphoma, with the purpose of emphasizing its inclusion within the differential diagnoses in the approach to lymphoid cutaneous lesions.
We present the clinical case of a 67-year-old female patient who presented with two painful, erythematous, nodular lesions on her left flank, approximately 10 mm in diameter. An excisional biopsy was performed on both specimens, fixed in 10% buffered formalin, embedded in paraffin, and stained with hematoxylin and eosin. Microscopically, the superficial and mid-dermis, and focally the deep dermis, revealed lymphoid proliferation with light and darker areas, whose cells are arranged in nodules and diffuse areas. These cells have medium-sized, hyperchromic nuclei with atypical mitotic figures and scant cytoplasm. Some have larger, vesicular nuclei, while others are lymphoplasmacytoid and plasma cells. Immunohistochemistry was requested, with the following results: CD3: -, CD20: +, BCL2: +, BCL6: -, CD10: -, KI67: 40%, with a diagnosis of cutaneous marginal zone lymphoma.
The rare, usually indolent cutaneous lymphoma is notable for its variability of presentation and the need for an accurate diagnosis for proper treatment and follow-up. |
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2025 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/50432 |
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I10-R327-article-504322025-11-13T12:04:31Z Linfoma cutáneo de la zona marginal Cutaneous marginal zone lymphom . Valenzuela, S Moyano Crespo, GD Matsuzaki, M Rufino, R Silva, I Caggia, A Valenzuela, S Moyano Crespo, GD Matsuzaki, M Rufino, R Silva, I Caggia, A Valenzuela, S Moyano Crespo, GD Matsuzaki, M Rufino, R Silva, I Caggia, A linfoma de Células B de la Zona Marginal linfoma MALT linfoma cutaneo linfoma de Células B de la Zona Marginal linfoma MALT linfoma cutaneo marginal zone B-cell lymphoma MALT lymphoma cutaneous lymphoma Primary cutaneous marginal zone B-cell lymphoma is an indolent lymphoid neoplasm originating in post-germinal B lymphocytes of the extranodal mucosa-associated lymphoid tissue (MALT) of the skin. Its frequency is 7% to 9% of all primary cutaneous lymphomas. It is associated with chronic inflammatory and autoimmune processes. There are four histopathological variants: conventional, lymphoplasmacytic, plasmacytic, and blastoid. Conventional is the most common. It generally affects young adults, often men, and presents as reddish-brown papules, plaques, or nodules on the upper extremities or torso. These can be solitary or multiple. The histomorphology presents a characteristic triad: reactive lymphoid follicles, diffuse infiltration of small lymphocytes, and lymphoepithelial lesions with a morphology similar to Peyer's patches. The conventional variant has an excellent prognosis, with an estimated 5-year survival rate of 98%. Recurrences can occur in 40–50% of patients. The objective is to report an unusual variant of cutaneous lymphoma, with the purpose of emphasizing its inclusion within the differential diagnoses in the approach to lymphoid cutaneous lesions. We present the clinical case of a 67-year-old female patient who presented with two painful, erythematous, nodular lesions on her left flank, approximately 10 mm in diameter. An excisional biopsy was performed on both specimens, fixed in 10% buffered formalin, embedded in paraffin, and stained with hematoxylin and eosin. Microscopically, the superficial and mid-dermis, and focally the deep dermis, revealed lymphoid proliferation with light and darker areas, whose cells are arranged in nodules and diffuse areas. These cells have medium-sized, hyperchromic nuclei with atypical mitotic figures and scant cytoplasm. Some have larger, vesicular nuclei, while others are lymphoplasmacytoid and plasma cells. Immunohistochemistry was requested, with the following results: CD3: -, CD20: +, BCL2: +, BCL6: -, CD10: -, KI67: 40%, with a diagnosis of cutaneous marginal zone lymphoma. The rare, usually indolent cutaneous lymphoma is notable for its variability of presentation and the need for an accurate diagnosis for proper treatment and follow-up. El linfoma de células B de la zona marginal primario cutáneo es una neoplasia linfoide indolente, que se origina en los linfocitos B post-germinales del tejido linfoide extranodal asociado a mucosas (MALT) de la piel. Comprende en frecuencia del 7% al 9% de todos los linfomas cutáneos primarios. Se relaciona con procesos inflamatorios crónicos y autoinmunes. Existen cuatro variantes histopatológicas: Convencional, Linfoplasmocitaria, Plasmocítica y Blastoide. Siendo la Convencional la más frecuente, generalmente afecta a adultos jóvenes, con frecuencia hombres y se presenta como pápulas, placas o nódulos pardo-rojizos en extremidades superiores o tronco. Pueden ser solitarias o múltiples. La histomorfología presenta una triada característica: folículos linfoides reactivos, infiltración difusa de linfocitos pequeños y lesiones linfoepiteliales con morfología similar a las placas de Peyer. La variante convencional tiene excelente pronóstico y la supervivencia estimada a 5 años es del 98%. Se pueden observar recurrencias en el 40-50% de los pacientes. El objetivo del presente trabajo es comunicar una variante de linfoma cutáneo inusual, con el propósito de enfatizar su inclusión dentro de los diagnósticos diferenciales en el abordaje de lesiones cutáneas linfoides. Se presenta el caso clínico de paciente femenina de 67 años, que consulta por 2 lesiones nodulares, eritematosas, en flanco izquierdo, de 10 mm de diámetro aproximado, dolorosas. Se realizó biopsia escisional de ambas, se fijaron en formol buffer al 10%, se incluyeron en parafina y colorearon con hematoxilina y eosina, evidenciando microscópicamente en dermis superficial, media y focalmente dermis profunda, una proliferación linfoide con zonas claras y otras más oscuras, cuyas células se disponen conformando nódulos y áreas difusas. Las mismas son de núcleos medianos, hipercrómicos con figuras de mitosis atípicas y escaso citoplasma, algunas presentan núcleos de mayor tamaño y vesiculosos, otras son de tipo linfoplasmocitoides y células plasmáticas. Se solicitaron técnicas de inmunohistoquímica cuyos resultados fueron: CD3: - , CD20: +, BCL2: +, BCL6: -, CD10: -, KI67: 40 %, con diagnóstico de linfoma cutáneo de la zona marginal. El Linfoma Cutáneo poco frecuente, usualmente indolente, destaca por su variabilidad de presentación y la necesidad de un diagnóstico preciso, para un correcto tratamiento y seguimiento evolutivo. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2025-11-12 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/50432 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 82 (2025): Suplemento JIC XXVI Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 82 (2025): Suplemento JIC XXVI Revista da Faculdade de Ciências Médicas de Córdoba; v. 82 (2025): Suplemento JIC XXVI 1853-0605 0014-6722 spa https://revistas.unc.edu.ar/index.php/med/article/view/50432/50600 Derechos de autor 2025 Universidad Nacional de Córdoba https://creativecommons.org/licenses/by-nc/4.0 |