Clinical and Imaging Features in Patients with Cirrhosis and Hepatocellular Carcinoma at a Tertiary Hospital in Córdoba

Introduction: Liver cirrhosis is a global public health problem, increasing the risk of hepatocellular carcinoma (HCC), a highly aggressive cancer. Early diagnosis through imaging studies is crucial for timely treatment. Objective: To describe the clinical and imaging characteristics of patients wit...

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Detalles Bibliográficos
Autores principales: Oliva, Virginia, Muiño, Gustavo, Orozco, Santiago, Saad, Emanuel José
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2025
Materias:
liver cirrhosis
hepatocellular carcinoma
tomography spiral computed
magnetic resonance
carcinoma hepatocelular
tomografía computarizada espiral
resonancia magnética
cirrosis hepática
cirrose hepática alcoólica
tomografia computadorizada espiral
espectroscopia de ressonância magnética
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/46375
Aporte de:
Revista de la Facultad de Ciencias Médicas de Córdoba de Universidad Nacional de Córdoba
Descripción
Sumario:Introduction: Liver cirrhosis is a global public health problem, increasing the risk of hepatocellular carcinoma (HCC), a highly aggressive cancer. Early diagnosis through imaging studies is crucial for timely treatment. Objective: To describe the clinical and imaging characteristics of patients with cirrhosis and HCC at a tertiary hospital in Córdoba, Argentina. Methods: A retrospective analytical study reviewed the medical records of patients with cirrhosis and/or HCC who underwent computed tomography (CT) and/or magnetic resonance imaging (MRI) between 2017 and 2023. Results: A total of 221 cirrhotic patients were included, 142 (64.3%) of whom were male, with a median: interquartile range 25-75% (n IQR) age of 60: 54-66 years. The etiologies were: alcoholic (30.3%), non-alcoholic steatohepatitis (NASH) (26.2%), hepatitis B (21.7%), hepatitis C (12.2%), and others (9.5%). HCC was diagnosed in 42 (19%) patients. CT was performed on all patients, and MRI on 22 (52.4%). Among patients with HCC, NASH was the most common cause (38.1%). LI-RADS criteria classified 30 (71.4%) patients as LI-RADS-5, while 12 (28.6%) progressed from lower categories. During an 18-month follow-up, 22 (9.95%) cirrhotic patients died. Conclusions: Alcoholic cirrhosis was the leading cause, and HCC was diagnosed in 19% of patients. CT was performed in all HCC patients, and MRI in half. Both modalities demonstrated HCC characteristics in more than 95% of cases. The 18-month mortality was 9.95% in cirrhotic patients and 16% in patients with HCC.

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