Clinical and Imaging Features in Patients with Cirrhosis and Hepatocellular Carcinoma at a Tertiary Hospital in Córdoba
Introduction: Liver cirrhosis is a global public health problem, increasing the risk of hepatocellular carcinoma (HCC), a highly aggressive cancer. Early diagnosis through imaging studies is crucial for timely treatment. Objective: To describe the clinical and imaging characteristics of patients wit...
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2025
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/46375 |
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I10-R327-article-46375 |
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ojs |
| institution |
Universidad Nacional de Córdoba |
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I-10 |
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R-327 |
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Revista de la Facultad de Ciencias Médicas de Córdoba |
| language |
Español |
| format |
Artículo revista |
| topic |
liver cirrhosis hepatocellular carcinoma tomography spiral computed magnetic resonance carcinoma hepatocelular tomografía computarizada espiral resonancia magnética cirrosis hepática cirrose hepática alcoólica carcinoma hepatocelular tomografia computadorizada espiral espectroscopia de ressonância magnética |
| spellingShingle |
liver cirrhosis hepatocellular carcinoma tomography spiral computed magnetic resonance carcinoma hepatocelular tomografía computarizada espiral resonancia magnética cirrosis hepática cirrose hepática alcoólica carcinoma hepatocelular tomografia computadorizada espiral espectroscopia de ressonância magnética Oliva, Virginia Muiño, Gustavo Orozco, Santiago Saad, Emanuel José Oliva, Virginia Muiño, Gustavo Orozco, Santiago Saad, Emanuel José Oliva, Virginia Muiño, Gustavo Orozco, Santiago Saad, Emanuel José Clinical and Imaging Features in Patients with Cirrhosis and Hepatocellular Carcinoma at a Tertiary Hospital in Córdoba |
| topic_facet |
liver cirrhosis hepatocellular carcinoma tomography spiral computed magnetic resonance carcinoma hepatocelular tomografía computarizada espiral resonancia magnética cirrosis hepática cirrose hepática alcoólica carcinoma hepatocelular tomografia computadorizada espiral espectroscopia de ressonância magnética |
| author |
Oliva, Virginia Muiño, Gustavo Orozco, Santiago Saad, Emanuel José Oliva, Virginia Muiño, Gustavo Orozco, Santiago Saad, Emanuel José Oliva, Virginia Muiño, Gustavo Orozco, Santiago Saad, Emanuel José |
| author_facet |
Oliva, Virginia Muiño, Gustavo Orozco, Santiago Saad, Emanuel José Oliva, Virginia Muiño, Gustavo Orozco, Santiago Saad, Emanuel José Oliva, Virginia Muiño, Gustavo Orozco, Santiago Saad, Emanuel José |
| author_sort |
Oliva, Virginia |
| title |
Clinical and Imaging Features in Patients with Cirrhosis and Hepatocellular Carcinoma at a Tertiary Hospital in Córdoba |
| title_short |
Clinical and Imaging Features in Patients with Cirrhosis and Hepatocellular Carcinoma at a Tertiary Hospital in Córdoba |
| title_full |
Clinical and Imaging Features in Patients with Cirrhosis and Hepatocellular Carcinoma at a Tertiary Hospital in Córdoba |
| title_fullStr |
Clinical and Imaging Features in Patients with Cirrhosis and Hepatocellular Carcinoma at a Tertiary Hospital in Córdoba |
| title_full_unstemmed |
Clinical and Imaging Features in Patients with Cirrhosis and Hepatocellular Carcinoma at a Tertiary Hospital in Córdoba |
| title_sort |
clinical and imaging features in patients with cirrhosis and hepatocellular carcinoma at a tertiary hospital in córdoba |
| description |
Introduction: Liver cirrhosis is a global public health problem, increasing the risk of hepatocellular carcinoma (HCC), a highly aggressive cancer. Early diagnosis through imaging studies is crucial for timely treatment.
Objective: To describe the clinical and imaging characteristics of patients with cirrhosis and HCC at a tertiary hospital in Córdoba, Argentina.
Methods: A retrospective analytical study reviewed the medical records of patients with cirrhosis and/or HCC who underwent computed tomography (CT) and/or magnetic resonance imaging (MRI) between 2017 and 2023.
Results: A total of 221 cirrhotic patients were included, 142 (64.3%) of whom were male, with a median: interquartile range 25-75% (n IQR) age of 60: 54-66 years. The etiologies were: alcoholic (30.3%), non-alcoholic steatohepatitis (NASH) (26.2%), hepatitis B (21.7%), hepatitis C (12.2%), and others (9.5%). HCC was diagnosed in 42 (19%) patients. CT was performed on all patients, and MRI on 22 (52.4%). Among patients with HCC, NASH was the most common cause (38.1%). LI-RADS criteria classified 30 (71.4%) patients as LI-RADS-5, while 12 (28.6%) progressed from lower categories. During an 18-month follow-up, 22 (9.95%) cirrhotic patients died.
Conclusions: Alcoholic cirrhosis was the leading cause, and HCC was diagnosed in 19% of patients. CT was performed in all HCC patients, and MRI in half. Both modalities demonstrated HCC characteristics in more than 95% of cases. The 18-month mortality was 9.95% in cirrhotic patients and 16% in patients with HCC. |
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2025 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/46375 |
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I10-R327-article-463752025-11-12T21:08:55Z Clinical and Imaging Features in Patients with Cirrhosis and Hepatocellular Carcinoma at a Tertiary Hospital in Córdoba Características clínicas y de imagen en pacientes con cirrosis y carcinoma hepatocelular en un hospital de tercer nivel de Córdoba Características clínicas e de imagem em pacientes com cirrose e carcinoma hepatocelular em um hospital terciário de Córdoba Oliva, Virginia Muiño, Gustavo Orozco, Santiago Saad, Emanuel José Oliva, Virginia Muiño, Gustavo Orozco, Santiago Saad, Emanuel José Oliva, Virginia Muiño, Gustavo Orozco, Santiago Saad, Emanuel José liver cirrhosis hepatocellular carcinoma tomography spiral computed magnetic resonance carcinoma hepatocelular tomografía computarizada espiral resonancia magnética cirrosis hepática cirrose hepática alcoólica carcinoma hepatocelular tomografia computadorizada espiral espectroscopia de ressonância magnética Introduction: Liver cirrhosis is a global public health problem, increasing the risk of hepatocellular carcinoma (HCC), a highly aggressive cancer. Early diagnosis through imaging studies is crucial for timely treatment. Objective: To describe the clinical and imaging characteristics of patients with cirrhosis and HCC at a tertiary hospital in Córdoba, Argentina. Methods: A retrospective analytical study reviewed the medical records of patients with cirrhosis and/or HCC who underwent computed tomography (CT) and/or magnetic resonance imaging (MRI) between 2017 and 2023. Results: A total of 221 cirrhotic patients were included, 142 (64.3%) of whom were male, with a median: interquartile range 25-75% (n IQR) age of 60: 54-66 years. The etiologies were: alcoholic (30.3%), non-alcoholic steatohepatitis (NASH) (26.2%), hepatitis B (21.7%), hepatitis C (12.2%), and others (9.5%). HCC was diagnosed in 42 (19%) patients. CT was performed on all patients, and MRI on 22 (52.4%). Among patients with HCC, NASH was the most common cause (38.1%). LI-RADS criteria classified 30 (71.4%) patients as LI-RADS-5, while 12 (28.6%) progressed from lower categories. During an 18-month follow-up, 22 (9.95%) cirrhotic patients died. Conclusions: Alcoholic cirrhosis was the leading cause, and HCC was diagnosed in 19% of patients. CT was performed in all HCC patients, and MRI in half. Both modalities demonstrated HCC characteristics in more than 95% of cases. The 18-month mortality was 9.95% in cirrhotic patients and 16% in patients with HCC. Introducción: La cirrosis hepática constituye un problema de salud pública global, incrementando el riesgo de carcinoma hepatocelular(CHC), un cáncer altamente agresivo. El diagnóstico temprano mediante estudios de imágenes es crucial para un tratamiento oportuno. El objetivo fue describir las características clínicas y por imágenes de pacientes con cirrosis y CHC en un hospital de tercer nivel de Córdoba, Argentina. Metodología: Estudio analítico retrospectivo que revisó historias clínicas de pacientes con cirrosis y/o CHC que se sometieron a tomografía computarizada(TC) y/o resonancia magnética(RM) entre 2017 y 2023. Resultados: Se incluyeron 221 pacientes cirróticos, 142(64,3%) varones, con una mediana: rango intercuartil 25-75%(n=RIC) de edad de 60: 54-66 años. Las etiologías fueron: alcohólica(30,3%), esteatohepatitis no alcohólica (NASH) (26,2%), hepatitis B(21,7%), hepatitis C (12,2%) y otras(9,5%). Se diagnosticó CHC en 42(19%) pacientes. Se realizó TC a todos los pacientes y RM a 22(52,4%). Entre los pacientes con CHC, NASH fue la causa más común(38,1%). Los criterios LI-RADS clasificaron a 30(71,4%) pacientes como LI-RADS-5, mientras que 12(28,6%) progresaron desde categorías más bajas. Durante el seguimiento de 18 meses, 22(9,95%) pacientes cirróticos fallecieron. Conclusiones: La cirrosis alcohólica fue la principal causa, y el CHC se diagnosticó en el 19% de los pacientes. Se realizó TC en todos los pacientes con CHC y RM en la mitad. Ambas modalidades demostraron características de CHC en más del 95% de los casos. La mortalidad a los 18 meses fue del 9,95% en pacientes cirróticos y del 16% en pacientes con CHC. Introdução: A cirrose hepática é um problema de saúde pública global, aumentando o risco de carcinoma hepatocelular (CHC), um câncer altamente agressivo. O diagnóstico precoce através de estudos de imagem é crucial para um tratamento oportuno.Objetivo: Descrever as características clínicas e de imagem de pacientes com cirrose e CHC em um hospital terciário de Córdoba, Argentina.Metodologia: Estudo analítico retrospectivo que revisou prontuários de pacientes com cirrose e/ou CHC submetidos à tomografia computadorizada (TC) e/ou ressonância magnética (RM) entre 2017 e 2023.Resultados: Foram incluídos 221 pacientes cirróticos, 142 (64,3%) homens, com uma mediana: intervalo interquartil 25-75% (n IIQ) de idade de 60: 54-66 anos. As etiologias foram: alcoólica (30,3%), esteato-hepatite não alcoólica (NASH) (26,2%), hepatite B (21,7%), hepatite C (12,2%) e outras (9,5%). CHC foi diagnosticado em 42 (19%) pacientes. TC foi realizada em todos os pacientes e RM em 22 (52,4%). Entre os pacientes com CHC, NASH foi a causa mais comum (38,1%). Os critérios LI-RADS classificaram 30 (71,4%) pacientes como LI-RADS-5, enquanto 12 (28,6%) progrediram de categorias inferiores. Durante o acompanhamento de 18 meses, 22 (9,95%) pacientes cirróticos faleceram.Conclusões: A cirrose alcoólica foi a principal causa e o CHC foi diagnosticado em 19% dos pacientes. TC foi realizada em todos os pacientes com CHC e RM na metade. Ambas as modalidades demonstraram características de CHC em mais de 95% dos casos. A mortalidade em 18 meses foi de 9,95% em pacientes cirróticos e de 16% em pacientes com CHC. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2025-09-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf text/html https://revistas.unc.edu.ar/index.php/med/article/view/46375 10.31053/1853.0605.v82.n3.46375 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 82 No. 3 (2025); 484-504 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 82 Núm. 3 (2025); 484-504 Revista da Faculdade de Ciências Médicas de Córdoba; v. 82 n. 3 (2025); 484-504 1853-0605 0014-6722 10.31053/1853.0605.v82.n3 spa https://revistas.unc.edu.ar/index.php/med/article/view/46375/50432 https://revistas.unc.edu.ar/index.php/med/article/view/46375/50475 Derechos de autor 2025 Universidad Nacional de Córdoba https://creativecommons.org/licenses/by-nc/4.0 |