Primary empty sella: a retrospective study
Introduction: Primary empty sella (PES) consists of herniation of the suprasellar subarachnoid space within the sella turcica in patients with no history of sellar pathology. Diagnosis is mostly made incidentally. Objective: Describe the characteristics of patients with PES. Methods: Patients with P...
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2025
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/46309 |
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I10-R327-article-46309 |
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Universidad Nacional de Córdoba |
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I-10 |
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R-327 |
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Revista de la Facultad de Ciencias Médicas de Córdoba |
| language |
Inglés |
| format |
Artículo revista |
| topic |
hypopituitarism pituitary diseases empty sella syndrome hipopituitarismo enfermedades de la hipófisis sindrome de silla turca vacia sindrome da sela vazia hipopituitarismo doenças da hipófise |
| spellingShingle |
hypopituitarism pituitary diseases empty sella syndrome hipopituitarismo enfermedades de la hipófisis sindrome de silla turca vacia sindrome da sela vazia hipopituitarismo doenças da hipófise Leon, Natalia Soledad Sosa, Soledad Coronel-Restrepo, Nicolas Pignatta, Analía Moncet, Daniel Morando, Jose Daniel Loto, Monica Graciela Escudero, Marisol Coronello, Elizabeth Rizzo , Leonardo Luis Danilowicz, Karina Leon, Natalia Soledad Pignatta, Analía Pignatta, Analía Primary empty sella: a retrospective study |
| topic_facet |
hypopituitarism pituitary diseases empty sella syndrome hipopituitarismo enfermedades de la hipófisis sindrome de silla turca vacia sindrome da sela vazia hipopituitarismo doenças da hipófise |
| author |
Leon, Natalia Soledad Sosa, Soledad Coronel-Restrepo, Nicolas Pignatta, Analía Moncet, Daniel Morando, Jose Daniel Loto, Monica Graciela Escudero, Marisol Coronello, Elizabeth Rizzo , Leonardo Luis Danilowicz, Karina Leon, Natalia Soledad Pignatta, Analía Pignatta, Analía |
| author_facet |
Leon, Natalia Soledad Sosa, Soledad Coronel-Restrepo, Nicolas Pignatta, Analía Moncet, Daniel Morando, Jose Daniel Loto, Monica Graciela Escudero, Marisol Coronello, Elizabeth Rizzo , Leonardo Luis Danilowicz, Karina Leon, Natalia Soledad Pignatta, Analía Pignatta, Analía |
| author_sort |
Leon, Natalia Soledad |
| title |
Primary empty sella: a retrospective study |
| title_short |
Primary empty sella: a retrospective study |
| title_full |
Primary empty sella: a retrospective study |
| title_fullStr |
Primary empty sella: a retrospective study |
| title_full_unstemmed |
Primary empty sella: a retrospective study |
| title_sort |
primary empty sella: a retrospective study |
| description |
Introduction: Primary empty sella (PES) consists of herniation of the suprasellar subarachnoid space within the sella turcica in patients with no history of sellar pathology. Diagnosis is mostly made incidentally.
Objective: Describe the characteristics of patients with PES.
Methods: Patients with PES from 6 Argentine centers specialized in Neuroendocrinology in Buenos Aires diagnosed between 1997-2021 were included. Diagnosis was based in sellar magnetic resonance, pituitary functional evaluation by baseline hormonal measurement and visual function assessed by neuro-ophthalmological evaluation and campimetry.
Results: Sixty-three patients with a mean age of 52.3 ± 13.2 years and a predominance of female gender (79%, 4:1 ratio) were included. The average BMI was 32.7 ± 8.13 kg/m2 and 68% were overweight or obese. HTA was also found in 59%. Among women, the parity frequency was 78%: 92% had multiple pregnancies. The diagnosis was incidental in 22%. In symptomatic patients (n= 49), the reasons for consultation were headache in 61%, symptoms of endocrine dysfunction in 51% and visual disturbances in 33%: 43% of the patients presented multiple symptoms. MRI showed partial PES in 63% and total PES in 37% of the patients. In the biochemical evaluation, hypopituitarism was observed in 46%.
Conclusions: Although the diagnosis of PES can be made incidentally, in our series most of the patients presented symptoms. Most of them were multiparous women, obese and hypertensive patients. Biochemical evaluation should be carried out to investigate isolated or multiple pituitary deficits in order to indicate the corresponding replacement treatment. |
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2025 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/46309 |
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I10-R327-article-463092025-11-12T21:08:55Z Primary empty sella: a retrospective study Silla turca vacia primaria: estudio retrospectivo Cadeira turca primária vazia: estudo retrospectivo Leon, Natalia Soledad Sosa, Soledad Coronel-Restrepo, Nicolas Pignatta, Analía Moncet, Daniel Morando, Jose Daniel Loto, Monica Graciela Escudero, Marisol Coronello, Elizabeth Rizzo , Leonardo Luis Danilowicz, Karina Leon, Natalia Soledad Pignatta, Analía Pignatta, Analía hypopituitarism pituitary diseases empty sella syndrome hipopituitarismo enfermedades de la hipófisis sindrome de silla turca vacia sindrome da sela vazia hipopituitarismo doenças da hipófise Introduction: Primary empty sella (PES) consists of herniation of the suprasellar subarachnoid space within the sella turcica in patients with no history of sellar pathology. Diagnosis is mostly made incidentally. Objective: Describe the characteristics of patients with PES. Methods: Patients with PES from 6 Argentine centers specialized in Neuroendocrinology in Buenos Aires diagnosed between 1997-2021 were included. Diagnosis was based in sellar magnetic resonance, pituitary functional evaluation by baseline hormonal measurement and visual function assessed by neuro-ophthalmological evaluation and campimetry. Results: Sixty-three patients with a mean age of 52.3 ± 13.2 years and a predominance of female gender (79%, 4:1 ratio) were included. The average BMI was 32.7 ± 8.13 kg/m2 and 68% were overweight or obese. HTA was also found in 59%. Among women, the parity frequency was 78%: 92% had multiple pregnancies. The diagnosis was incidental in 22%. In symptomatic patients (n= 49), the reasons for consultation were headache in 61%, symptoms of endocrine dysfunction in 51% and visual disturbances in 33%: 43% of the patients presented multiple symptoms. MRI showed partial PES in 63% and total PES in 37% of the patients. In the biochemical evaluation, hypopituitarism was observed in 46%. Conclusions: Although the diagnosis of PES can be made incidentally, in our series most of the patients presented symptoms. Most of them were multiparous women, obese and hypertensive patients. Biochemical evaluation should be carried out to investigate isolated or multiple pituitary deficits in order to indicate the corresponding replacement treatment. Introducción: La silla turca vacía primaria (STVP) consiste en la herniación del espacio subaracnoideo supraselar dentro de la silla turca en pacientes sin antecedentes de patología selar. El diagnóstico se realiza mayoritariamente de forma incidental. Objetivos: Describir las características de pacientes con STVP. Métodos: Pacientes de 6 centros argentinos especializados en Neuroendocrinología con STVP entre 1997-2021. El diagnóstico fue realizado mediante resonancia magnética selar (RM), la evaluación funcional hipofisaria por medición hormonal basal y la función visual mediante evaluación neuro-oftalmológica y campimetría. Resultados: Se incluyeron 63 pacientes con una edad promedio de 52.3± 13.2 años y predominio femenino (79%; 4:1). El IMC promedio fue de 32.7 ± 8.13 kg/m2 y un 68% presentaron sobrepeso u obesidad. El 59% presentaba HTA. Entre las mujeres, la frecuencia de paridad fue 78 %: 92% tuvieron embarazos múltiples. El diagnóstico fue incidental en 22% de los pacientes. En los pacientes sintomáticos (n= 49), los motivos de consulta fueron cefalea en el 61%, síntomas de disfunción endocrina en 51% y alteraciones visuales 33% . El 43% presentó más de un síntoma. La RM evidenció STV parcial en 63% y STV total en 37% de los pacientes. En el 46% se observó hipopituitarismo. Conclusiones: En nuestra serie la mayoría de los pacientes presentaron sintomatología. Se observó un claro predominio en mujeres multíparas, y en pacientes obesos e hipertensos. Debe instrumentarse la evaluación bioquímica para pesquisar el déficit pituitario aislado o múltiple e indicar el correspondiente tratamiento sustitutivo. Introdução: A sela vazia primária (SFE) consiste na herniação do espaço subaracnóideo suprasselar dentro da sela turca em pacientes sem histórico de patologia selar. O diagnóstico é feito principalmente de forma incidental. Objetivo: Descrever as características dos pacientes com PES. Métodos: Foram incluídos pacientes com PES de 6 centros argentinos especializados em Neuroendocrinologia em Buenos Aires, diagnosticados entre 1997-2021. O diagnóstico foi baseado na ressonância magnética selar, avaliação funcional hipofisária por dosagem hormonal basal e função visual avaliada por avaliação neuro-oftalmológica e campimetria. Resultados: Foram incluídos 63 pacientes com idade média de 52,3 ± 13,2 anos e predominância do sexo feminino (79%, proporção 4:1). O IMC médio foi de 32,7 ± 8,13 kg/m2 e 68% estavam com sobrepeso ou obesidade. ATS também foi encontrada em 59%. Entre as mulheres, a frequência de paridade foi de 78%: 92% tiveram gestações múltiplas. O diagnóstico foi incidental em 22%. Nos pacientes sintomáticos (n= 49), os motivos de consulta foram cefaleia em 61%, sintomas de disfunção endócrina em 51% e distúrbios visuais em 33%: 43% dos pacientes apresentavam sintomas múltiplos. A ressonância magnética mostrou PES parcial em 63% e PES total em 37% dos pacientes. Na avaliação bioquímica foi observado hipopituitarismo em 46%. Conclusões: Embora o diagnóstico de SEP possa ser feito incidentalmente, em nossa série a maioria dos pacientes apresentou sintomas. A maioria eram mulheres multíparas, obesas e hipertensas. Avaliação bioquímica deve ser realizada para investigação de déficits hipofisários isolados ou múltiplos, a fim de indicar o tratamento substitutivo correspondente. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2025-09-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion text/html application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/46309 10.31053/1853.0605.v82.n3.46309 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 82 No. 3 (2025); 544-554 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 82 Núm. 3 (2025); 544-554 Revista da Faculdade de Ciências Médicas de Córdoba; v. 82 n. 3 (2025); 544-554 1853-0605 0014-6722 10.31053/1853.0605.v82.n3 eng https://revistas.unc.edu.ar/index.php/med/article/view/46309/50144 https://revistas.unc.edu.ar/index.php/med/article/view/46309/50401 Derechos de autor 2025 Universidad Nacional de Córdoba https://creativecommons.org/licenses/by-nc/4.0 |