Serum indices of hepatic steatosis in indigenous Venezuelan adults of the Piaroa ethnic groupup
Introduction: metabolic dysfunction associated fatty liver disease (MAFLD) is a condition characterized by hepatic steatosis (HS) of metabolic origin. To predict it, HS serum indices (HSSI) have been proposed and validated, whose performance in indigenous populations is unknown. Objectives: to descr...
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2024
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/44477 |
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I10-R327-article-44477 |
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Universidad Nacional de Córdoba |
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I-10 |
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R-327 |
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Revista de la Facultad de Ciencias Médicas de Córdoba |
| language |
Español |
| format |
Artículo revista |
| topic |
fatty liver non-alcoholic fatty liver disease indians, south american indigenous peoples hígado graso enfermedad del hígado graso no alcohólico indios sudamericanos pueblos indígenas fígado gorduroso hepatopatia gordurosa não alcoólica índios sul-americanos povos indígenas |
| spellingShingle |
fatty liver non-alcoholic fatty liver disease indians, south american indigenous peoples hígado graso enfermedad del hígado graso no alcohólico indios sudamericanos pueblos indígenas fígado gorduroso hepatopatia gordurosa não alcoólica índios sul-americanos povos indígenas Nobrega, Doris Diaz-Castro, María José Freites-Portocarrero, Aaron Fuentes-Bielinis, Luisana Gaize-García, Bill Luna-Sánchez, Valentina Ruiz-Fernández, Nelina A. Serum indices of hepatic steatosis in indigenous Venezuelan adults of the Piaroa ethnic groupup |
| topic_facet |
fatty liver non-alcoholic fatty liver disease indians, south american indigenous peoples hígado graso enfermedad del hígado graso no alcohólico indios sudamericanos pueblos indígenas fígado gorduroso hepatopatia gordurosa não alcoólica índios sul-americanos povos indígenas |
| author |
Nobrega, Doris Diaz-Castro, María José Freites-Portocarrero, Aaron Fuentes-Bielinis, Luisana Gaize-García, Bill Luna-Sánchez, Valentina Ruiz-Fernández, Nelina A. |
| author_facet |
Nobrega, Doris Diaz-Castro, María José Freites-Portocarrero, Aaron Fuentes-Bielinis, Luisana Gaize-García, Bill Luna-Sánchez, Valentina Ruiz-Fernández, Nelina A. |
| author_sort |
Nobrega, Doris |
| title |
Serum indices of hepatic steatosis in indigenous Venezuelan adults of the Piaroa ethnic groupup |
| title_short |
Serum indices of hepatic steatosis in indigenous Venezuelan adults of the Piaroa ethnic groupup |
| title_full |
Serum indices of hepatic steatosis in indigenous Venezuelan adults of the Piaroa ethnic groupup |
| title_fullStr |
Serum indices of hepatic steatosis in indigenous Venezuelan adults of the Piaroa ethnic groupup |
| title_full_unstemmed |
Serum indices of hepatic steatosis in indigenous Venezuelan adults of the Piaroa ethnic groupup |
| title_sort |
serum indices of hepatic steatosis in indigenous venezuelan adults of the piaroa ethnic groupup |
| description |
Introduction: metabolic dysfunction associated fatty liver disease (MAFLD) is a condition characterized by hepatic steatosis (HS) of metabolic origin. To predict it, HS serum indices (HSSI) have been proposed and validated, whose performance in indigenous populations is unknown. Objectives: to describe the variation of cardiometabolic risk (CMR) indicators according to four SHSI in indigenous Venezuelans of the Piaroa ethnic group, and to explore the frequency of non-alcoholic fatty liver disease (NAFLD) and MAFLD in this population. Methodology: non-experimental, descriptive, correlational and cross-sectional study, with non-probabilistic and intentional sampling, in 75 indigenous Piaroas adults (18 to 65 years). The HSSI were used: FLI (Fatty Liver Index), HSI (Liver Steatosis Index), LAP (Lipid Accumulation Product) and VAI (Visceral Adiposity Index). Results: FLI values were higher in men and LAP values in women. FLI, LAP and VAI were higher in individuals ≥ 40 years old. Individuals with body mass index (BMI) ≥ 25 kg/m2 showed higher FLI, HSI and LAP values compared to individuals with lower BMI. Depending on the applied HSSI, the frequency of NAFLD varied between 1.3% and 40.5%, while for MAFLD it was between 2.7 and 21.6%. Conclusion: the increase in HSSI was associated with changes in CMR indicators compatible with the presence of fatty liver. The study of the metabolic profile of HS in the Piaroas indigenous people must be expanded, in order to design better focused prevention and therapeutic strategies. |
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2024 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/44477 |
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I10-R327-article-444772024-12-16T14:26:57Z Serum indices of hepatic steatosis in indigenous Venezuelan adults of the Piaroa ethnic groupup Índices séricos de esteatosis hepática en indígenas venezolanos adultos de la etnia Piaroa Índices séricos de esteatose hepática em adultos indígenas venezuelanos da etnia Piaroa Serum Nobrega, Doris Diaz-Castro, María José Freites-Portocarrero, Aaron Fuentes-Bielinis, Luisana Gaize-García, Bill Luna-Sánchez, Valentina Ruiz-Fernández, Nelina A. fatty liver non-alcoholic fatty liver disease indians, south american indigenous peoples hígado graso enfermedad del hígado graso no alcohólico indios sudamericanos pueblos indígenas fígado gorduroso hepatopatia gordurosa não alcoólica índios sul-americanos povos indígenas Introduction: metabolic dysfunction associated fatty liver disease (MAFLD) is a condition characterized by hepatic steatosis (HS) of metabolic origin. To predict it, HS serum indices (HSSI) have been proposed and validated, whose performance in indigenous populations is unknown. Objectives: to describe the variation of cardiometabolic risk (CMR) indicators according to four SHSI in indigenous Venezuelans of the Piaroa ethnic group, and to explore the frequency of non-alcoholic fatty liver disease (NAFLD) and MAFLD in this population. Methodology: non-experimental, descriptive, correlational and cross-sectional study, with non-probabilistic and intentional sampling, in 75 indigenous Piaroas adults (18 to 65 years). The HSSI were used: FLI (Fatty Liver Index), HSI (Liver Steatosis Index), LAP (Lipid Accumulation Product) and VAI (Visceral Adiposity Index). Results: FLI values were higher in men and LAP values in women. FLI, LAP and VAI were higher in individuals ≥ 40 years old. Individuals with body mass index (BMI) ≥ 25 kg/m2 showed higher FLI, HSI and LAP values compared to individuals with lower BMI. Depending on the applied HSSI, the frequency of NAFLD varied between 1.3% and 40.5%, while for MAFLD it was between 2.7 and 21.6%. Conclusion: the increase in HSSI was associated with changes in CMR indicators compatible with the presence of fatty liver. The study of the metabolic profile of HS in the Piaroas indigenous people must be expanded, in order to design better focused prevention and therapeutic strategies. Introducción: la enfermedad por hígado graso asociada a disfunción metabólica (EHGDM) es una afección caracterizada por esteatosis hepática (EH) de origen metabólico. Para predecirla, se han propuesto y validado índices séricos de EH (ISEH), cuyo desempeño en poblaciones indígenas se desconoce. Objetivos: describir la variación de indicadores de riesgo cardiometabólico (RCM) según cuatro ISEH en indígenas venezolanos de la etnia Piaroa, y explorar la frecuencia de enfermedad por hígado graso no alcohólico (EHGNA) y de EHGDM en esta población. Metodología: estudio no experimental, descriptivo, correlacional y transversal, con muestreo no probabilístico e intencional, en 75 indígenas Piaroas adultos (18 a 65 años). Se emplearon los ISEH: FLI (Índice de Hígado Graso), HSI (Índice de Esteatosis Hepática), LAP (Producto de Acumulación de Lípidos) y VAI (Índice de Adiposidad Visceral). Resultados: los valores de FLI fueron más elevados en los hombres y los de LAP en las mujeres. FLI, LAP y VAI fueron más elevados en individuos ≥ 40 años. Los individuos con índice de masa corporal (IMC) ≥ 25 kg/m2 mostraron valores de FLI, HSI y LAP superiores respecto de individuos con menor IMC. Según el ISEH aplicado, la frecuencia de EHGNA varió entre 1,3% y 40,5%, mientras que para EHGDM se ubicó entre 2,7 y 21,6%. Conclusión: el incremento de los ISEH se asoció a cambios en indicadores de RCM compatibles con la presencia de hígado graso. Debe ampliarse el estudio del perfil metabólico de la EH en los indígenas Piaroas, para diseñar estrategias de prevención y terapéutica mejor enfocadas. Introdução: a doença hepática gordurosa metabólica (DHGM) é uma condição caracterizada por esteatose hepática (EH) de origem metabólica. Para predizê-lo, foram propostos e validados índices séricos de EH (ISEH), cujo desempenho em populações indígenas é desconhecido. Objetivos: descrever a variação dos indicadores de risco cardiometabólico (RCM) de acordo com quatro ISEH em indígenas venezuelanos da etnia Piaroa e explorar a frequência de doença hepática gordurosa não alcoólica (DHGNA) e DHGM nesta população. Metodologia: estudo não experimental, descritivo, correlacional e transversal, com amostragem não probabilística e intencional, em 75 adultos indígenas Piaroas (18 a 65 anos). Foram utilizados os ISEH: IFG (Índice de Fígado Gordo), IEH (Índice de Esteatose Hepática), PAL (Produto de Acumulação Lipídica) e IAV (Índice de Adiposidade Visceral). Resultados: os valores do IFG foram maiores nos homens e os valores do PAL nas mulheres. O IFG, o PAL e o IAV foram maiores nos indivíduos ≥ 40 anos de idade. Indivíduos com índice de massa corporal (IMC) ≥ 25 kg/m2 apresentaram maiores valores de IFG, IEH e PAL em comparação aos indivíduos com menor IMC. Dependendo do ISEH aplicado, a frequência de DHGNA variou entre 1,3% e 40,5%, enquanto para DHGM ficou entre 2,7 e 21,6%. Conclusão: o aumento dos ISEH foi associado a alterações nos indicadores de RMC compatíveis com a presença de fígado gorduroso. O estudo do perfil metabólico da EH nos povos indígenas Piaroas deve ser ampliado, a fim de desenhar estratégias preventivas e terapêuticas mais focadas. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2024-12-13 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion text/html application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/44477 10.31053/1853.0605.v81.n4.44477 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 81 No. 4 (2024); 686-704 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 81 Núm. 4 (2024); 686-704 Revista da Faculdade de Ciências Médicas de Córdoba; v. 81 n. 4 (2024); 686-704 1853-0605 0014-6722 10.31053/1853.0605.v81.n4 spa https://revistas.unc.edu.ar/index.php/med/article/view/44477/47457 https://revistas.unc.edu.ar/index.php/med/article/view/44477/47458 Derechos de autor 2024 Universidad Nacional de Córdoba https://creativecommons.org/licenses/by-nc/4.0 |