Obstetric and neonatal outcomes in pregnancies conceived by assisted reproductive technology in an Argentine cohort.
Introduction: Since its introduction in clinical practice in 1981, pregnancies conceived by assisted reproductive techniques (ART) are an increasing proportion of all pregnancies, presenting particular challenges. Objective: To analyze the maternal-fetal outcomes of pregnancies conceived by ART in a...
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| Lenguaje: | Español |
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2024
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/44425 |
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I10-R327-article-44425 |
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ojs |
| institution |
Universidad Nacional de Córdoba |
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I-10 |
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R-327 |
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Revista de la Facultad de Ciencias Médicas de Córdoba |
| language |
Español |
| format |
Artículo revista |
| topic |
reproductive techniques, assisted pregnancy complications pregnancy outcome perinatal care técnicas reproductivas asistidas complicaciones del embarazo resultado del embarazo atención perinatal técnicas de reprodução assistida complicações na gravidez resultado da gravidez assistência perinatal |
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reproductive techniques, assisted pregnancy complications pregnancy outcome perinatal care técnicas reproductivas asistidas complicaciones del embarazo resultado del embarazo atención perinatal técnicas de reprodução assistida complicações na gravidez resultado da gravidez assistência perinatal Diez Brito, Macarena Sevillano, Gonzalo Negri, Florence Mongelos, Miracles Diez Brito, Macarena Sevillano, Gonzalo Negri, Florencia Mongelos, Milagros Izbizky, Gustavo Diez Brito, Macarena Sevillano, Gonzalo Negri, Florença Mongelos, Milgros Obstetric and neonatal outcomes in pregnancies conceived by assisted reproductive technology in an Argentine cohort. |
| topic_facet |
reproductive techniques, assisted pregnancy complications pregnancy outcome perinatal care técnicas reproductivas asistidas complicaciones del embarazo resultado del embarazo atención perinatal técnicas de reprodução assistida complicações na gravidez resultado da gravidez assistência perinatal |
| author |
Diez Brito, Macarena Sevillano, Gonzalo Negri, Florence Mongelos, Miracles Diez Brito, Macarena Sevillano, Gonzalo Negri, Florencia Mongelos, Milagros Izbizky, Gustavo Diez Brito, Macarena Sevillano, Gonzalo Negri, Florença Mongelos, Milgros |
| author_facet |
Diez Brito, Macarena Sevillano, Gonzalo Negri, Florence Mongelos, Miracles Diez Brito, Macarena Sevillano, Gonzalo Negri, Florencia Mongelos, Milagros Izbizky, Gustavo Diez Brito, Macarena Sevillano, Gonzalo Negri, Florença Mongelos, Milgros |
| author_sort |
Diez Brito, Macarena |
| title |
Obstetric and neonatal outcomes in pregnancies conceived by assisted reproductive technology in an Argentine cohort. |
| title_short |
Obstetric and neonatal outcomes in pregnancies conceived by assisted reproductive technology in an Argentine cohort. |
| title_full |
Obstetric and neonatal outcomes in pregnancies conceived by assisted reproductive technology in an Argentine cohort. |
| title_fullStr |
Obstetric and neonatal outcomes in pregnancies conceived by assisted reproductive technology in an Argentine cohort. |
| title_full_unstemmed |
Obstetric and neonatal outcomes in pregnancies conceived by assisted reproductive technology in an Argentine cohort. |
| title_sort |
obstetric and neonatal outcomes in pregnancies conceived by assisted reproductive technology in an argentine cohort. |
| description |
Introduction: Since its introduction in clinical practice in 1981, pregnancies conceived by assisted reproductive techniques (ART) are an increasing proportion of all pregnancies, presenting particular challenges.
Objective: To analyze the maternal-fetal outcomes of pregnancies conceived by ART in a single center in Argentina.
Material and methods: Retrospective cohort of pregnancies conceived by ART who attended their delivery in a private university hospital through a review of records.
Results: The incidence of composite primary maternal outcome was 40,1% (282/703), with hypertensive disease of pregnancy (21%) being the most frequent presenting pathology.In the multivariate analysis, age > 40 (OR 2,79; 95%CI: 1,82-4,26), chronic hypertension (OR 10,59; 95% CI: 2,81-39,86), twin pregnancy (OR 8,94; 95% CI: 5,39 – 14,80) and oocyte donation (OR 1,54; 95% CI: 1,04 – 2,27) were significantly associated with the maternal primary outcome. The incidence of the composite neonatal fetal primary outcome was 56,7% (468/824), with a prematurity rate of 34,5% (252/803). In the multivariate analysis of the composite outcome of the neonatal fetus, twin pregnancy (OR 7,08; 95% CI: 3,48 – 14,39) and other complications related to prematurity were statistically significantly associated with the composite outcome.
Conclusions: Pregnancies conceived by ART show a significant increase in adverse maternal outcomes, mainly hypertension, and fetal and neonatal outcomes (prematurity, malformations, and admission to the intensive care unit). |
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2024 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/44425 |
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I10-R327-article-444252024-12-18T14:06:35Z Obstetric and neonatal outcomes in pregnancies conceived by assisted reproductive technology in an Argentine cohort. Resultados obstétricos y neonatales en embarazos logrados por fertilización asistida en una cohorte Argentina. Resultados obstétricos e neonatais em gestações obtidas por fertilização assistida em uma coorte argentina Diez Brito, Macarena Sevillano, Gonzalo Negri, Florence Mongelos, Miracles Diez Brito, Macarena Sevillano, Gonzalo Negri, Florencia Mongelos, Milagros Izbizky, Gustavo Diez Brito, Macarena Sevillano, Gonzalo Negri, Florença Mongelos, Milgros reproductive techniques, assisted pregnancy complications pregnancy outcome perinatal care técnicas reproductivas asistidas complicaciones del embarazo resultado del embarazo atención perinatal técnicas de reprodução assistida complicações na gravidez resultado da gravidez assistência perinatal Introduction: Since its introduction in clinical practice in 1981, pregnancies conceived by assisted reproductive techniques (ART) are an increasing proportion of all pregnancies, presenting particular challenges. Objective: To analyze the maternal-fetal outcomes of pregnancies conceived by ART in a single center in Argentina. Material and methods: Retrospective cohort of pregnancies conceived by ART who attended their delivery in a private university hospital through a review of records. Results: The incidence of composite primary maternal outcome was 40,1% (282/703), with hypertensive disease of pregnancy (21%) being the most frequent presenting pathology.In the multivariate analysis, age > 40 (OR 2,79; 95%CI: 1,82-4,26), chronic hypertension (OR 10,59; 95% CI: 2,81-39,86), twin pregnancy (OR 8,94; 95% CI: 5,39 – 14,80) and oocyte donation (OR 1,54; 95% CI: 1,04 – 2,27) were significantly associated with the maternal primary outcome. The incidence of the composite neonatal fetal primary outcome was 56,7% (468/824), with a prematurity rate of 34,5% (252/803). In the multivariate analysis of the composite outcome of the neonatal fetus, twin pregnancy (OR 7,08; 95% CI: 3,48 – 14,39) and other complications related to prematurity were statistically significantly associated with the composite outcome. Conclusions: Pregnancies conceived by ART show a significant increase in adverse maternal outcomes, mainly hypertension, and fetal and neonatal outcomes (prematurity, malformations, and admission to the intensive care unit). Introducción: Desde su introducción en 1981, los embarazos logrados por técnicas de reproducción asistida (TRA) son una proporción cada vez más grande de todas las gestaciones, presentando desafíos particulares. Objetivo: Analizar los resultados maternos-fetales de los embarazos logrados por TRA en un centro único de Argentina. Material y métodos: Cohorte retrospectiva de embarazos logrados por TRA que atendieron su parto en un hospital privado universitario mediante revisión de registros. Resultados: La incidencia del resultado materno primario compuesto fue del 40,1% (282/703), siendo la patología de presentación más frecuente la enfermedad hipertensiva del embarazo (21%)En el análisis multivariado, la edad > 40 (OR 2,79; IC95%: 1,82-4.26), la hipertensión crónica (OR 10,59; IC95%: 2,81- 39,86), el embarazo gemelar (OR 8,94; IC95%: 5,39 – 14,80) y la ovo donación (OR 1,54; IC95%: 1,04 – 2,27) se asociaron significativamente con el resultado primario materno. La incidencia del resultado primario feto neonatal compuesto fue del 56,7% (468/824), con una tasa de prematuridad del 34,5% (252/803). En el análisis multivariado del resultado compuesto feto neonatal, el embarazo gemelar (OR 7,08; IC95%: 3,48 – 14,39) y otras complicaciones relacionadas a la prematuridad se asociaron en forma estadísticamente significativa con el resultado compuesto. Conclusiones: Los embarazos logrados por TRA muestran un aumento significativo de resultados adversos tanto maternos, principalmente hipertensión; como fetales y neonatales (prematuridad, malformaciones e ingreso a unidad de cuidados intensivos). Introdução: Desde a sua introdução em 1981, as gestações alcançadas por técnicas de reprodução assistida (TRA) são uma proporção crescente de todas as gestações, apresentando desafios particulares. Objetivo: Analisar os resultados materno-fetais das gestações alcançadas pela TARV em um único centro na Argentina. Material e métodos: Coorte retrospectiva de gestações realizadas por TARV que assistiram ao parto em um hospital universitário privado por meio de revisão de prontuários. Resultados: A incidência de desfecho materno primário composto foi de 40,1% (282/703), sendo a doença hipertensiva da gestação (21%) a patologia de apresentação mais frequente na análise multivariada, a idade ( 40 anos (OR 2,79; IC95%: 1,82-4,26), hipertensão arterial crônica (OR 10,59; IC 95%: 2,81-39,86), gestação gemelar (OR 8,94; IC 95%: 5,39 – 14,80) e doação de óvulos (OR 1,54; IC 95%: 1,04 – 2,27) associaram-se significativamente com o desfecho primário materno. A incidência do desfecho fetal fetal composto primário neonatal foi de 56,7% (468/824), com taxa de prematuridade de 34,5% (252/803). Na análise multivariada do desfecho composto do feto neonatal, gestação gemelar (OR 7,08; IC 95%: 3,48 – 14,39) e outras complicações relacionadas à prematuridade foram estatisticamente significativas associadas ao desfecho composto. Conclusões: As gestações alcançadas pela TARV mostram um aumento significativo nos desfechos maternos adversos, principalmente hipertensão; além de fetais e neonatais (prematuridade, malformações e internação em unidade de terapia intensiva). Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2024-12-13 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf text/html https://revistas.unc.edu.ar/index.php/med/article/view/44425 10.31053/1853.0605.v81.n4.44425 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 81 No. 4 (2024); 734-751 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 81 Núm. 4 (2024); 734-751 Revista da Faculdade de Ciências Médicas de Córdoba; v. 81 n. 4 (2024); 734-751 1853-0605 0014-6722 10.31053/1853.0605.v81.n4 spa https://revistas.unc.edu.ar/index.php/med/article/view/44425/47622 https://revistas.unc.edu.ar/index.php/med/article/view/44425/47850 Derechos de autor 2024 Universidad Nacional de Córdoba https://creativecommons.org/licenses/by-nc/4.0 |