Anemia and heart failure with preserved ejection fraction in adult patients with cardiorenal syndrome: a cross-sectional study

Introduction: Patients hospitalized for heart failure with preserved ejection fraction (HFpEF) have a higher prevalence of anemia than those hospitalized for heart failure with reduced ejection fraction (HFpEF). However, it is unknown if this relationship is maintained in patients with chronic kidne...

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Autores principales: Politi, Maria Teresa, Daquarti, Gustavo Javier, Spagnuolo, Damián Néstor, Ferreyra, Raúl, Diez, Mirta, Bortman, Guillermo
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2025
Materias:
cardio-renal syndrome
heart failure, diastolic
anemia
renal insufficiency, chronic
síndrome cardiorrenal
insuficiência cardíaca diastólica
insuficiencia cardíaca diastólica
enfermedad renal crónica
insuficiência renal crônica.
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/44359
Aporte de:
Revista de la Facultad de Ciencias Médicas de Córdoba de Universidad Nacional de Córdoba
id I10-R327-article-44359
record_format ojs
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-327
container_title_str Revista de la Facultad de Ciencias Médicas de Córdoba
language Español
format Artículo revista
topic cardio-renal syndrome
heart failure, diastolic
anemia
renal insufficiency, chronic
síndrome cardiorrenal
insuficiência cardíaca diastólica
síndrome cardiorrenal
insuficiencia cardíaca diastólica
anemia
enfermedad renal crónica
síndrome cardiorrenal
insuficiência cardíaca diastólica
anemia
insuficiência renal crônica.
spellingShingle cardio-renal syndrome
heart failure, diastolic
anemia
renal insufficiency, chronic
síndrome cardiorrenal
insuficiência cardíaca diastólica
síndrome cardiorrenal
insuficiencia cardíaca diastólica
anemia
enfermedad renal crónica
síndrome cardiorrenal
insuficiência cardíaca diastólica
anemia
insuficiência renal crônica.
Politi, Maria Teresa
Daquarti, Gustavo Javier
Spagnuolo, Damián Néstor
Ferreyra, Raúl
Diez, Mirta
Bortman, Guillermo
Anemia and heart failure with preserved ejection fraction in adult patients with cardiorenal syndrome: a cross-sectional study
topic_facet cardio-renal syndrome
heart failure, diastolic
anemia
renal insufficiency, chronic
síndrome cardiorrenal
insuficiência cardíaca diastólica
síndrome cardiorrenal
insuficiencia cardíaca diastólica
anemia
enfermedad renal crónica
síndrome cardiorrenal
insuficiência cardíaca diastólica
anemia
insuficiência renal crônica.
author Politi, Maria Teresa
Daquarti, Gustavo Javier
Spagnuolo, Damián Néstor
Ferreyra, Raúl
Diez, Mirta
Bortman, Guillermo
author_facet Politi, Maria Teresa
Daquarti, Gustavo Javier
Spagnuolo, Damián Néstor
Ferreyra, Raúl
Diez, Mirta
Bortman, Guillermo
author_sort Politi, Maria Teresa
title Anemia and heart failure with preserved ejection fraction in adult patients with cardiorenal syndrome: a cross-sectional study
title_short Anemia and heart failure with preserved ejection fraction in adult patients with cardiorenal syndrome: a cross-sectional study
title_full Anemia and heart failure with preserved ejection fraction in adult patients with cardiorenal syndrome: a cross-sectional study
title_fullStr Anemia and heart failure with preserved ejection fraction in adult patients with cardiorenal syndrome: a cross-sectional study
title_full_unstemmed Anemia and heart failure with preserved ejection fraction in adult patients with cardiorenal syndrome: a cross-sectional study
title_sort anemia and heart failure with preserved ejection fraction in adult patients with cardiorenal syndrome: a cross-sectional study
description Introduction: Patients hospitalized for heart failure with preserved ejection fraction (HFpEF) have a higher prevalence of anemia than those hospitalized for heart failure with reduced ejection fraction (HFpEF). However, it is unknown if this relationship is maintained in patients with chronic kidney disease, forming cardiorenal syndrome type IV. Methods: Cross-sectional, multicenter study of patients with chronic kidney disease hospitalized for heart failure. The primary outcome was the difference in hemoglobin concentration. The secondary outcome was the difference in the prevalence of anemia. Results: 229 patients were enrolled. Hemoglobin concentration was lower in patients with HFpEF compared to patients with HFrEF (11.1±1.8 g/dl vs 12.3±2.0 g/dl; p < 0.0001). . Presenting HFpEF was associated with a lower hemoglobin concentration (β1 = -0.90 g/dl; p = 0.001), after including the use of iron supplements, moderate to severe deterioration of glomerular filtration rate, sex and age. The prevalence of anemia was higher in patients with HFpEF compared to those with HFrEF (72.3% vs 59.8%; p = 0.0462). Belonging to the HFpEF group was not associated with anemia (OR = 1.77; p = 0.078), after including the same covariates. Exploratory, belonging to the HFpEF group was associated with moderate to severe anemia, after including the same covariates. Conclusion: In patients with type IV cardiorenal syndrome, hemoglobin concentration is lower in patients hospitalized with HFpEF, possibly playing a role in the destabilization of these patients.
publisher Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2025
url https://revistas.unc.edu.ar/index.php/med/article/view/44359
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spelling I10-R327-article-443592025-03-31T17:43:09Z Anemia and heart failure with preserved ejection fraction in adult patients with cardiorenal syndrome: a cross-sectional study Anemia e insuficiencia cardíaca con fracción de eyección conservada en pacientes adultos con síndrome cardiorrenal: un estudio de corte transversal Anemia e insuficiência cardíaca com fração de ejeção preservada em pacientes adultos com síndrome cardiorrenal: estudo transversal Politi, Maria Teresa Daquarti, Gustavo Javier Spagnuolo, Damián Néstor Ferreyra, Raúl Diez, Mirta Bortman, Guillermo cardio-renal syndrome heart failure, diastolic anemia renal insufficiency, chronic síndrome cardiorrenal insuficiência cardíaca diastólica síndrome cardiorrenal insuficiencia cardíaca diastólica anemia enfermedad renal crónica síndrome cardiorrenal insuficiência cardíaca diastólica anemia insuficiência renal crônica. Introduction: Patients hospitalized for heart failure with preserved ejection fraction (HFpEF) have a higher prevalence of anemia than those hospitalized for heart failure with reduced ejection fraction (HFpEF). However, it is unknown if this relationship is maintained in patients with chronic kidney disease, forming cardiorenal syndrome type IV. Methods: Cross-sectional, multicenter study of patients with chronic kidney disease hospitalized for heart failure. The primary outcome was the difference in hemoglobin concentration. The secondary outcome was the difference in the prevalence of anemia. Results: 229 patients were enrolled. Hemoglobin concentration was lower in patients with HFpEF compared to patients with HFrEF (11.1±1.8 g/dl vs 12.3±2.0 g/dl; p < 0.0001). . Presenting HFpEF was associated with a lower hemoglobin concentration (β1 = -0.90 g/dl; p = 0.001), after including the use of iron supplements, moderate to severe deterioration of glomerular filtration rate, sex and age. The prevalence of anemia was higher in patients with HFpEF compared to those with HFrEF (72.3% vs 59.8%; p = 0.0462). Belonging to the HFpEF group was not associated with anemia (OR = 1.77; p = 0.078), after including the same covariates. Exploratory, belonging to the HFpEF group was associated with moderate to severe anemia, after including the same covariates. Conclusion: In patients with type IV cardiorenal syndrome, hemoglobin concentration is lower in patients hospitalized with HFpEF, possibly playing a role in the destabilization of these patients. Introducción: Los pacientes internados por insuficiencia cardíaca con fracción de eyección conservada (IC-FEc) tienen mayor prevalencia de anemia que aquellos internados por insuficiencia cardíaca con fracción de eyección reducida (IC-FEr). Sin embargo, se desconoce si esta relación se mantiene en pacientes con enfermedad renal crónica, conformando el síndrome cardiorrenal tipo IV. Métodos: Estudio de corte trasversal, multicéntrico, de pacientes con enfermedad renal crónica internados por insuficiencia cardíaca. El desenlace primario fue la diferencia en la concentración de hemoglobina. El desenlace secundario fue la diferencia en la prevalencia de anemia. Resultados: Se enrolaron 229 pacientes. La concentración de hemoglobina fue menor en pacientes con IC-FEc en relación a los pacientes con IC-FEr (11,1±1,8 g/dl vs 12,3±2,0 g/dl; p < 0,0001). Presentar IC-FEc estaba asociado a una menor concentración de hemoglobina (β1 = -0,90 g/dl; p = 0,001), luego de incluir el uso de suplementos de hierro, el deterioro moderado a grave del filtrado glomerular, el sexo y la edad. La prevalencia de anemia fue mayor en pacientes con IC-FEc en relación a aquellos con IC-FEr (72,3% vs 59,8%; p = 0,0462). Pertenecer al grupo de IC-FEc no se asoció con anemia (OR = 1,77; p = 0,078), luego de incluir las mismas covariables. Exploratoriamente, pertenecer al grupo de IC-FEc se asoció con anemia moderada a grave, luego de incluir las mismas covariables. Conclusión: En pacientes con síndrome cardiorrenal tipo IV la concentración de hemoglobina es menor en pacientes internados con IC-FEc, posiblemente jugando un rol en la desestabilización de estos pacientes. Introdução: Pacientes hospitalizados por insuficiência cardíaca com fração de ejeção preservada (ICFEp) apresentam maior prevalência de anemia do que aqueles hospitalizados por insuficiência cardíaca com fração de ejeção reduzida (ICFEp). Entretanto, não se sabe se essa relação se mantém em pacientes com doença renal crônica, formando a síndrome cardiorrenal tipo IV. Métodos: Estudo transversal e multicêntrico de pacientes com doença renal crônica internados por insuficiência cardíaca. O desfecho primário foi a diferença na concentração de hemoglobina. O desfecho secundário foi a diferença na prevalência de anemia. Resultados: 229 pacientes foram incluídos. A concentração de hemoglobina foi menor em pacientes com ICFEp em comparação com pacientes com ICFEr (11,1±1,8 g/dl vs 12,3±2,0 g/dl; p < 0,0001). Presentar IC-FEc estaba asociado a una menor concentración de hemoglobina (β1 = -0,90 g/dl; p = 0,001), luego de incluir el uso de suplementos de hierro, el deterioro moderado a grave del filtrado glomerular, el sexo y idade. A prevalência de anemia foi maior em pacientes com ICFEp em comparação com aqueles com ICFEr (72,3% vs 59,8%; p = 0,0462). Pertencer ao grupo ICFEP não se associou à anemia (OR = 1,77; p = 0,078), após inclusão das mesmas covariáveis. Exploratório, pertencer ao grupo ICFEP foi associado à anemia moderada a grave, após inclusão das mesmas covariáveis. Conclusão: Em pacientes com síndrome cardiorrenal tipo IV, a concentração de hemoglobina é menor em pacientes hospitalizados com ICFEP, possivelmente desempenhando um papel na desestabilização desses pacientes. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2025-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion text/html application/pdf application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/44359 10.31053/1853.0605.v82.n1.44359 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 82 No. 1 (2025); 22-40 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 82 Núm. 1 (2025); 22-40 Revista da Faculdade de Ciências Médicas de Córdoba; v. 82 n. 1 (2025); 22-40 1853-0605 0014-6722 10.31053/1853.0605.v82.n1 spa https://revistas.unc.edu.ar/index.php/med/article/view/44359/48552 https://revistas.unc.edu.ar/index.php/med/article/view/44359/48593 https://revistas.unc.edu.ar/index.php/med/article/view/44359/48594 Derechos de autor 2025 Universidad Nacional de Córdoba https://creativecommons.org/licenses/by-nc/4.0

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