Analysis of various compounds in commercial yerbas preparations and their potential medication interactions
For centuries, medicinal plants have been included in numerous infusions to prevent illnesses and promote health. In our country, it is common to consume them in combination with 'yerba mate', without considering that their active compounds can interact with medications, primarily in their...
Guardado en:
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Artículo revista |
| Lenguaje: | Español |
| Publicado: |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2023
|
| Materias: | |
| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/42782 |
| Aporte de: |
| id |
I10-R327-article-42782 |
|---|---|
| record_format |
ojs |
| institution |
Universidad Nacional de Córdoba |
| institution_str |
I-10 |
| repository_str |
R-327 |
| container_title_str |
Revista de la Facultad de Ciencias Médicas de Córdoba |
| language |
Español |
| format |
Artículo revista |
| topic |
medicinal herbs interactions with medications Public Health yerba mate blends Plantas Medicinales consumo de yerba salud pública, información |
| spellingShingle |
medicinal herbs interactions with medications Public Health yerba mate blends Plantas Medicinales consumo de yerba salud pública, información Di Dino, E Eandi , L Monti, A Pérez, M Teme, MA Ricarte Bratti, JP Grigorjev, C Brizuela, NY Analysis of various compounds in commercial yerbas preparations and their potential medication interactions |
| topic_facet |
medicinal herbs interactions with medications Public Health yerba mate blends Plantas Medicinales consumo de yerba salud pública, información |
| author |
Di Dino, E Eandi , L Monti, A Pérez, M Teme, MA Ricarte Bratti, JP Grigorjev, C Brizuela, NY |
| author_facet |
Di Dino, E Eandi , L Monti, A Pérez, M Teme, MA Ricarte Bratti, JP Grigorjev, C Brizuela, NY |
| author_sort |
Di Dino, E |
| title |
Analysis of various compounds in commercial yerbas preparations and their potential medication interactions |
| title_short |
Analysis of various compounds in commercial yerbas preparations and their potential medication interactions |
| title_full |
Analysis of various compounds in commercial yerbas preparations and their potential medication interactions |
| title_fullStr |
Analysis of various compounds in commercial yerbas preparations and their potential medication interactions |
| title_full_unstemmed |
Analysis of various compounds in commercial yerbas preparations and their potential medication interactions |
| title_sort |
analysis of various compounds in commercial yerbas preparations and their potential medication interactions |
| description |
For centuries, medicinal plants have been included in numerous infusions to prevent illnesses and promote health. In our country, it is common to consume them in combination with 'yerba mate', without considering that their active compounds can interact with medications, primarily in their metabolism or elimination from the body. This study aims to identify the most widely distributed medicinal herbs in the local market within yerba mate blends and assess whether there are interactions with medications commonly used by the general population.
A survey was conducted by visiting different supermarkets in the City of Córdoba. Twelve brands of 'yerba mate' containing commonly used herbs were considered. Subsequently, a descriptive statistical analysis of proportions was performed to determine which herbs are the most commonly marketed, followed by a literature review for each.
Based on the sample of analyzed yerba mate blends, it was determined that: 84% contained “menta”, 76% contained “poleo”, 32% contained “peperina”, 32% contained “cedrón”, 24% contained “manzanilla”, 12% contained “boldo”, 8% contained “burro”, 8% contained “marcela”, 4% contained “tilo”, 4% contained “salvia”, and 4% contained “eucalipto”. None of the yerba mate blends analyzed described the quantity or percentage of herbs used in each presentation.
Previous studies indicate that “manzanilla” reduces the enzyme of cytochrome P-450 (CYP3A4), potentially increasing the concentration of calcium antagonists and statins such as simvastatin and lovastatin. It also affects the central nervous system, synergizing its sedative effect with drugs like benzodiazepines; reduces iron absorption, and increases the risk of bleeding when used with oral anticoagulants. It is also important to mention the interaction between the active principle of “yerba mate” and various medications due to its effect on reducing clearance, leading to increased activity of antibiotics like ciprofloxacin and calcium antagonists like verapamil. In conclusion, it is essential to consider that the consumption of medicinal herbs is not without risks, even though their therapeutic margin may be broad. Chronic consumption of these substances could lead to significant interactions with medications used to treat various medical conditions. |
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2023 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/42782 |
| work_keys_str_mv |
AT didinoe analysisofvariouscompoundsincommercialyerbaspreparationsandtheirpotentialmedicationinteractions AT eandil analysisofvariouscompoundsincommercialyerbaspreparationsandtheirpotentialmedicationinteractions AT montia analysisofvariouscompoundsincommercialyerbaspreparationsandtheirpotentialmedicationinteractions AT perezm analysisofvariouscompoundsincommercialyerbaspreparationsandtheirpotentialmedicationinteractions AT temema analysisofvariouscompoundsincommercialyerbaspreparationsandtheirpotentialmedicationinteractions AT ricartebrattijp analysisofvariouscompoundsincommercialyerbaspreparationsandtheirpotentialmedicationinteractions AT grigorjevc analysisofvariouscompoundsincommercialyerbaspreparationsandtheirpotentialmedicationinteractions AT brizuelany analysisofvariouscompoundsincommercialyerbaspreparationsandtheirpotentialmedicationinteractions AT didinoe relevamientodelosdistintoscomponentesdeyerbascomercialesyposiblesinteraccionesmedicamentosas AT eandil relevamientodelosdistintoscomponentesdeyerbascomercialesyposiblesinteraccionesmedicamentosas AT montia relevamientodelosdistintoscomponentesdeyerbascomercialesyposiblesinteraccionesmedicamentosas AT perezm relevamientodelosdistintoscomponentesdeyerbascomercialesyposiblesinteraccionesmedicamentosas AT temema relevamientodelosdistintoscomponentesdeyerbascomercialesyposiblesinteraccionesmedicamentosas AT ricartebrattijp relevamientodelosdistintoscomponentesdeyerbascomercialesyposiblesinteraccionesmedicamentosas AT grigorjevc relevamientodelosdistintoscomponentesdeyerbascomercialesyposiblesinteraccionesmedicamentosas AT brizuelany relevamientodelosdistintoscomponentesdeyerbascomercialesyposiblesinteraccionesmedicamentosas |
| first_indexed |
2024-09-03T21:04:59Z |
| last_indexed |
2024-09-03T21:04:59Z |
| _version_ |
1809210408858288128 |
| spelling |
I10-R327-article-427822023-10-19T21:19:14Z Analysis of various compounds in commercial yerbas preparations and their potential medication interactions Relevamiento de los distintos componentes de yerbas comerciales y posibles interacciones medicamentosas Di Dino, E Eandi , L Monti, A Pérez, M Teme, MA Ricarte Bratti, JP Grigorjev, C Brizuela, NY medicinal herbs interactions with medications Public Health yerba mate blends Plantas Medicinales consumo de yerba salud pública, información For centuries, medicinal plants have been included in numerous infusions to prevent illnesses and promote health. In our country, it is common to consume them in combination with 'yerba mate', without considering that their active compounds can interact with medications, primarily in their metabolism or elimination from the body. This study aims to identify the most widely distributed medicinal herbs in the local market within yerba mate blends and assess whether there are interactions with medications commonly used by the general population. A survey was conducted by visiting different supermarkets in the City of Córdoba. Twelve brands of 'yerba mate' containing commonly used herbs were considered. Subsequently, a descriptive statistical analysis of proportions was performed to determine which herbs are the most commonly marketed, followed by a literature review for each. Based on the sample of analyzed yerba mate blends, it was determined that: 84% contained “menta”, 76% contained “poleo”, 32% contained “peperina”, 32% contained “cedrón”, 24% contained “manzanilla”, 12% contained “boldo”, 8% contained “burro”, 8% contained “marcela”, 4% contained “tilo”, 4% contained “salvia”, and 4% contained “eucalipto”. None of the yerba mate blends analyzed described the quantity or percentage of herbs used in each presentation. Previous studies indicate that “manzanilla” reduces the enzyme of cytochrome P-450 (CYP3A4), potentially increasing the concentration of calcium antagonists and statins such as simvastatin and lovastatin. It also affects the central nervous system, synergizing its sedative effect with drugs like benzodiazepines; reduces iron absorption, and increases the risk of bleeding when used with oral anticoagulants. It is also important to mention the interaction between the active principle of “yerba mate” and various medications due to its effect on reducing clearance, leading to increased activity of antibiotics like ciprofloxacin and calcium antagonists like verapamil. In conclusion, it is essential to consider that the consumption of medicinal herbs is not without risks, even though their therapeutic margin may be broad. Chronic consumption of these substances could lead to significant interactions with medications used to treat various medical conditions. Durante siglos se han incluido plantas medicinales en distintas infusiones para prevenir enfermedades y promover la salud. En nuestro país es frecuente su consumo combinado con "yerba mate", sin tener en cuenta que los principios activos de las mismas pueden interactuar con medicamentos principalmente en su metabolismo o eliminación del organismo. Se propone dar a conocer cuáles son las hierbas medicinales más difundidas en el mercado local dentro de las yerbas, y valorar si existen interacciones con medicamentos ampliamente utilizada en la población en general. Se llevó a cabo un trabajo de relevamiento, concurriendo a diferentes supermercados en la Ciudad de Córdoba. Se consideraron 12 marcas de yerba mate las que contenían hierbas de uso común. Posteriormente, se realizó un análisis de estadístico descriptiva de proporciones, para determinar cuáles son las hierbas más comercializadas y se realizó una revisión literaria acerca de cada una. En base a la muestra de yerbas analizadas se determinó que: un 84% contenía menta, 76% poleo, 32% peperina, 32% cedrón, 24% manzanilla, 12% boldo, 8% burro, 8% marcela, 4% tilo, 4% salvia, eucalipto 4%; en ninguna de las yerbas analizadas describe la cantidad o porcentaje de las hierbas usadas en cada presentación. Trabajos previos dan cuenta que la manzanilla dismuye las enzimas del citocromo P-450 (CYP3A4) y con ello puede aumentar la concentración de antagonistas cálcicos y de estatinas como la sinvastastina y lovastatina. Además posee acción sobre sistema nervioso central produciendo una sinérgia en cuanto a su efecto sedante, con fármacos como las benzodiacepinas; puede disminuir la absorción de hierro e incrementar el riesgo de sangrado con anticoagulantes orales. Es también importante mencionar la interacción entre el principio activo de la yerba-mate y los diversos medicamentos por el efecto sobre la disminución del clearance aumentando la actividad de fármacos antibióticos como la ciprofloxacina, y antagonistas cálcicos como el verapamilo. En conclusión, hay que tener en cuenta que el consumo de hierbas medicinales no son inócuos, aunque su margen terapeutico sean muy amplios, y que el consumo crónico de estas sustancias podría llevar a interacciones importantes con medicamentos utilizados para distintas patologías. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2023-10-19 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/42782 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 80 (2023): Suplemento JIC XXIV Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 80 (2023): Suplemento JIC XXIV Revista da Faculdade de Ciências Médicas de Córdoba; v. 80 (2023): Suplemento JIC XXIV 1853-0605 0014-6722 spa https://revistas.unc.edu.ar/index.php/med/article/view/42782/42817 Derechos de autor 2023 Universidad Nacional de Córdoba http://creativecommons.org/licenses/by-nc/4.0 |