Human Papillomavirus in Women: An Analysis of Coinfection in the Lower Genital Tract and Oral Mucosa
Cervical cancer is the seventh most frequent and the second in women worldwide. The Human Papilloma Virus (HPV) is the main cause of this type of cancer. HPV is also associated with head and neck cancers. Factors such as tobacco, alcohol and sexual practices influence these infections. Specific...
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| Autores principales: | , , |
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| Formato: | Artículo revista |
| Lenguaje: | Español |
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2023
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/42711 |
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I10-R327-article-42711 |
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Universidad Nacional de Córdoba |
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Revista de la Facultad de Ciencias Médicas de Córdoba |
| language |
Español |
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Artículo revista |
| topic |
cérvix mouth sexual dysplasia papilloma cérvix boca sexual displasia papiloma |
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cérvix mouth sexual dysplasia papilloma cérvix boca sexual displasia papiloma Zayas, SS Mariconde, JM Cuffini, CG Human Papillomavirus in Women: An Analysis of Coinfection in the Lower Genital Tract and Oral Mucosa |
| topic_facet |
cérvix mouth sexual dysplasia papilloma cérvix boca sexual displasia papiloma |
| author |
Zayas, SS Mariconde, JM Cuffini, CG |
| author_facet |
Zayas, SS Mariconde, JM Cuffini, CG |
| author_sort |
Zayas, SS |
| title |
Human Papillomavirus in Women: An Analysis of Coinfection in the Lower Genital Tract and Oral Mucosa |
| title_short |
Human Papillomavirus in Women: An Analysis of Coinfection in the Lower Genital Tract and Oral Mucosa |
| title_full |
Human Papillomavirus in Women: An Analysis of Coinfection in the Lower Genital Tract and Oral Mucosa |
| title_fullStr |
Human Papillomavirus in Women: An Analysis of Coinfection in the Lower Genital Tract and Oral Mucosa |
| title_full_unstemmed |
Human Papillomavirus in Women: An Analysis of Coinfection in the Lower Genital Tract and Oral Mucosa |
| title_sort |
human papillomavirus in women: an analysis of coinfection in the lower genital tract and oral mucosa |
| description |
Cervical cancer is the seventh most frequent and the second in women worldwide. The Human Papilloma Virus (HPV) is the main cause of this type of cancer. HPV is also associated with head and neck cancers. Factors such as tobacco, alcohol and sexual practices influence these infections. Specific HPV genotypes were detected at both locations. Objectives: General Objectives: •Determine the presence of HPV and its different genotypes in the oral mucosa of patients with high and low grade cervical lesions. Specific Objectives: •Correlate the presence of HPV in different epithelia associated with sexual behaviors. •Associate the presentation of lesions in different locations with the viral subtypes. •Analyze the correlation between oral lesions and those in the lower genital tract.
Design: analytical cross-sectional observational study. Problem Cases: 150 cases divided into women from 18 to 35 years of age and over 35 years of age. Control cases: 150 control cases with ages that will be included in a margin of 5 years compared to the problem cases.
Of the group with pathology of the genital tract, 63% had low-grade SIL, 14% condylomatosis, and 23% high-grade SIL, corresponding to 12.5% of high-grade SILs over 35 years of age and 87.5% to minors of that age. In the problem group, HPV was detected in 47.2% of the genital mucosa and in 9% of the oral mucosa. We obtained a significant difference (p <0.05) in virus detection in patients with previous injury (problem group). 80% of patients with virus detection practiced oral sex in the problem group, and 100% in the control group.
The presence of HPV in the genital tract could be a risk factor for oral infection. The presentation of lesions in colposcopy or histopathological diagnosis linkable to HPV lesions does not ensure the presence of the virus. Data to support the hypothesis are lacking and this could be due to the size of the study.
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| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2023 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/42711 |
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I10-R327-article-427112023-10-19T21:19:44Z Human Papillomavirus in Women: An Analysis of Coinfection in the Lower Genital Tract and Oral Mucosa Virus del Papiloma Humano en Mujeres: Un Análisis de la Coinfección en el Tracto Genital Inferior y la Mucosa Oral Zayas, SS Mariconde, JM Cuffini, CG cérvix mouth sexual dysplasia papilloma cérvix boca sexual displasia papiloma Cervical cancer is the seventh most frequent and the second in women worldwide. The Human Papilloma Virus (HPV) is the main cause of this type of cancer. HPV is also associated with head and neck cancers. Factors such as tobacco, alcohol and sexual practices influence these infections. Specific HPV genotypes were detected at both locations. Objectives: General Objectives: •Determine the presence of HPV and its different genotypes in the oral mucosa of patients with high and low grade cervical lesions. Specific Objectives: •Correlate the presence of HPV in different epithelia associated with sexual behaviors. •Associate the presentation of lesions in different locations with the viral subtypes. •Analyze the correlation between oral lesions and those in the lower genital tract. Design: analytical cross-sectional observational study. Problem Cases: 150 cases divided into women from 18 to 35 years of age and over 35 years of age. Control cases: 150 control cases with ages that will be included in a margin of 5 years compared to the problem cases. Of the group with pathology of the genital tract, 63% had low-grade SIL, 14% condylomatosis, and 23% high-grade SIL, corresponding to 12.5% of high-grade SILs over 35 years of age and 87.5% to minors of that age. In the problem group, HPV was detected in 47.2% of the genital mucosa and in 9% of the oral mucosa. We obtained a significant difference (p <0.05) in virus detection in patients with previous injury (problem group). 80% of patients with virus detection practiced oral sex in the problem group, and 100% in the control group. The presence of HPV in the genital tract could be a risk factor for oral infection. The presentation of lesions in colposcopy or histopathological diagnosis linkable to HPV lesions does not ensure the presence of the virus. Data to support the hypothesis are lacking and this could be due to the size of the study. El cáncer de cuello uterino es el séptimo más frecuente y el segundo en mujeres a nivel mundial. El Virus del Papiloma Humano (VPH) es la principal causa de este tipo de cáncer. El VPH también se asocia con cánceres de cabeza y cuello. Factores como el tabaco, alcohol y prácticas sexuales influyen en estas infecciones. Se detectaron genotipos específicos de VPH en ambas localizaciones. Objetivos: Objetivos Generales: •Determinar la presencia de VPH y sus diferentes genotipos en mucosa oral de pacientes con lesiones cervicales de alto y bajo grado. Objetivos Específicos: •Correlacionar la presencia del VPH en diferentes epitelios asociado a conductas sexuales. •Asociar la presentación de lesiones en distintas localizaciones con los subtipos virales. •Analizar la correlación entre lesiones orales y en el tracto genital inferior. Diseño: estudio observacional de corte transversal analítico. Casos Problema: 150 casos divididos en mujeres de 18 a 35 años y mayores de 35 años. Casos control: 150 casos controles con edades que estarán comprendidas en un margen de 5 años comparados con los casos problema. Del grupo con patología del tracto genital, el 63% presentaban SIL de bajo grado, el 14% condilomatosis y el 23% SIL de alto grado, correspondiendo el 12,5% de los SIL de alto grado a mayores de 35 años y el 87,5% a menores de esa edad. En el grupo problema el VPH se detectó en el 47,2% de mucosa genital y en el 9% de mucosa oral. Obtuvimos una diferencia significativa (p <0,05) en la detección del virus en pacientes con lesión previa (grupo problema). El 80% de pacientes con detección del virus practicaban sexo oral en el grupo problema, y el 100% en el grupo control. La presencia del VPH en el tracto genital podría ser factor de riesgo para infección oral. La presentación de lesiones en colposcopía o diagnóstico histopatológico vinculable a lesiones por VPH no asegura la presencia del virus. Faltan datos que apoyen la hipótesis y esto podría deberse al tamaño del estudio. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2023-10-19 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/42711 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 80 (2023): Suplemento JIC XXIV Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 80 (2023): Suplemento JIC XXIV Revista da Faculdade de Ciências Médicas de Córdoba; v. 80 (2023): Suplemento JIC XXIV 1853-0605 0014-6722 spa https://revistas.unc.edu.ar/index.php/med/article/view/42711/42883 Derechos de autor 2023 Universidad Nacional de Córdoba http://creativecommons.org/licenses/by-nc/4.0 |