Clinical presentation of congenital infection by human Parvovirus B19 in newborns treated at University Hospital of Maternity and Neonatology. 2021-2022

Human Parvovirus B19/B19V is among the congenital infection/vertical transmission viruses included in the TORCH group (Toxoplasmosis-Rubella-Chagas-Syphilis-O:others). The characteristics for its suspicion/case definition are not yet well defined, with fetal-neonatal hydrops being the most widely re...

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Autores principales: Boggio, GA, Colazo Salbetti, B, Moreno, MB, Pedranti, M, Miranda, MT, Vaca, B, Adamo, MP
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2023
Materias:
human parvovirus b19
serology
viraemia
hydrops fetalis
TORCH
parvovirus humano b19
serología
viremia
hidropesía fetal
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/42701
Aporte de:
Revista de la Facultad de Ciencias Médicas de Córdoba de Universidad Nacional de Córdoba
id I10-R327-article-42701
record_format ojs
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-327
container_title_str Revista de la Facultad de Ciencias Médicas de Córdoba
language Español
format Artículo revista
topic human parvovirus b19
serology
viraemia
hydrops fetalis
TORCH
parvovirus humano b19
serología
viremia
hidropesía fetal
TORCH
spellingShingle human parvovirus b19
serology
viraemia
hydrops fetalis
TORCH
parvovirus humano b19
serología
viremia
hidropesía fetal
TORCH
Boggio, GA
Colazo Salbetti, B
Moreno, MB
Pedranti, M
Miranda, MT
Vaca, B
Adamo, MP
Clinical presentation of congenital infection by human Parvovirus B19 in newborns treated at University Hospital of Maternity and Neonatology. 2021-2022
topic_facet human parvovirus b19
serology
viraemia
hydrops fetalis
TORCH
parvovirus humano b19
serología
viremia
hidropesía fetal
TORCH
author Boggio, GA
Colazo Salbetti, B
Moreno, MB
Pedranti, M
Miranda, MT
Vaca, B
Adamo, MP
author_facet Boggio, GA
Colazo Salbetti, B
Moreno, MB
Pedranti, M
Miranda, MT
Vaca, B
Adamo, MP
author_sort Boggio, GA
title Clinical presentation of congenital infection by human Parvovirus B19 in newborns treated at University Hospital of Maternity and Neonatology. 2021-2022
title_short Clinical presentation of congenital infection by human Parvovirus B19 in newborns treated at University Hospital of Maternity and Neonatology. 2021-2022
title_full Clinical presentation of congenital infection by human Parvovirus B19 in newborns treated at University Hospital of Maternity and Neonatology. 2021-2022
title_fullStr Clinical presentation of congenital infection by human Parvovirus B19 in newborns treated at University Hospital of Maternity and Neonatology. 2021-2022
title_full_unstemmed Clinical presentation of congenital infection by human Parvovirus B19 in newborns treated at University Hospital of Maternity and Neonatology. 2021-2022
title_sort clinical presentation of congenital infection by human parvovirus b19 in newborns treated at university hospital of maternity and neonatology. 2021-2022
description Human Parvovirus B19/B19V is among the congenital infection/vertical transmission viruses included in the TORCH group (Toxoplasmosis-Rubella-Chagas-Syphilis-O:others). The characteristics for its suspicion/case definition are not yet well defined, with fetal-neonatal hydrops being the most widely recognized. Its early diagnosis can prevent complications and optimize therapeutic management. Objectives: to identify the presence of congenital B19V infection in newborns/NBs treated at the Maternity and Neonatology University Hospital/HUMN and describe the clinical presentation in positive cases. A total of 63 newborns with parvoviral/TORCH symptoms and 9 with a history of confirmed maternal B19V infection during pregnancy, attended at HUMN-2021-2022, whose mothers agreed to participate (with signed consent), were included. In cord and/or peripheral blood, viral DNA was determined by molecular biology/PCR and specific IgG and IgM antibodies by ELISA. Maternal clinical data were investigated in positive cases of symptomatic newborns. The newborns studied for symptoms included suspected/confirmed cases of Syphilis/VDRL 15, Chagas 3, Toxoplasmosis 5; also hydrops 3, hyperbilirubinemia 14, hepatitis/cholestasis 5, polyhydramnios 2, among others (anemia, intrauterine growth retardation, renal failure, myocarditis, coagulation disorders, hepatosplenomegaly). In this group, 4/63 (6.3%) newborns were identified with congenital B19V infection: 1/4 with hydrops and anemia, 1/4 with polyhydramnios and hyperbilirubinemia, 1/4 with maternal B19V+Syphilis/VDRL and 1/4 with B19V. +Maternal Chagas. Among the newborns born to mothers with B19V infection during pregnancy, 1/9 presented vertical infection (with fetal-neonatal hydrops). The most frequent maternal symptom was anemia (8/9). In conclusion, 4 newborns with parvoviral infection and  clinical signs of the TORCH spectrum were identified during the study period. In addition, vertical transmission was confirmed in 11% of cases with a maternal history of B19V infection during pregnancy. Anemia was the most prevalent maternal history and hydrops, anemia and hyperbilirubinemia, that of NBs, so they could be considered in the design of diagnostic algorithms for B19V among the cases of vertical transmission of the TORCH group.
publisher Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2023
url https://revistas.unc.edu.ar/index.php/med/article/view/42701
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spelling I10-R327-article-427012023-10-19T21:19:49Z Clinical presentation of congenital infection by human Parvovirus B19 in newborns treated at University Hospital of Maternity and Neonatology. 2021-2022 Presentación clínica de la infección congénita por Parvovirus humano B19 en recién nacidos atendidos en el Hospital Universitario de Maternidad y Neonatología. 2021-2022 Boggio, GA Colazo Salbetti, B Moreno, MB Pedranti, M Miranda, MT Vaca, B Adamo, MP human parvovirus b19 serology viraemia hydrops fetalis TORCH parvovirus humano b19 serología viremia hidropesía fetal TORCH Human Parvovirus B19/B19V is among the congenital infection/vertical transmission viruses included in the TORCH group (Toxoplasmosis-Rubella-Chagas-Syphilis-O:others). The characteristics for its suspicion/case definition are not yet well defined, with fetal-neonatal hydrops being the most widely recognized. Its early diagnosis can prevent complications and optimize therapeutic management. Objectives: to identify the presence of congenital B19V infection in newborns/NBs treated at the Maternity and Neonatology University Hospital/HUMN and describe the clinical presentation in positive cases. A total of 63 newborns with parvoviral/TORCH symptoms and 9 with a history of confirmed maternal B19V infection during pregnancy, attended at HUMN-2021-2022, whose mothers agreed to participate (with signed consent), were included. In cord and/or peripheral blood, viral DNA was determined by molecular biology/PCR and specific IgG and IgM antibodies by ELISA. Maternal clinical data were investigated in positive cases of symptomatic newborns. The newborns studied for symptoms included suspected/confirmed cases of Syphilis/VDRL 15, Chagas 3, Toxoplasmosis 5; also hydrops 3, hyperbilirubinemia 14, hepatitis/cholestasis 5, polyhydramnios 2, among others (anemia, intrauterine growth retardation, renal failure, myocarditis, coagulation disorders, hepatosplenomegaly). In this group, 4/63 (6.3%) newborns were identified with congenital B19V infection: 1/4 with hydrops and anemia, 1/4 with polyhydramnios and hyperbilirubinemia, 1/4 with maternal B19V+Syphilis/VDRL and 1/4 with B19V. +Maternal Chagas. Among the newborns born to mothers with B19V infection during pregnancy, 1/9 presented vertical infection (with fetal-neonatal hydrops). The most frequent maternal symptom was anemia (8/9). In conclusion, 4 newborns with parvoviral infection and  clinical signs of the TORCH spectrum were identified during the study period. In addition, vertical transmission was confirmed in 11% of cases with a maternal history of B19V infection during pregnancy. Anemia was the most prevalent maternal history and hydrops, anemia and hyperbilirubinemia, that of NBs, so they could be considered in the design of diagnostic algorithms for B19V among the cases of vertical transmission of the TORCH group. El Parvovirus humano B19/B19V se encuentra entre los virus de infección congénita/transmisión vertical  incluidos en el grupo TORCH (Toxoplasmosis-Rubéola-Chagas-Sífilis-O:otros). Las características para su sospecha/definición de caso no están aún bien definidas, siendo la hidropesía feto-neonatal la más reconocida. Su diagnóstico precoz puede prevenir complicaciones y optimizar el manejo terapéutico. Objetivos: identificar presencia de infección congénita por B19V en recién nacidos/RN atendidos en Hospital Universitario de Maternidad y Neonatología/HUMN y describir la presentación clínica en los casos positivos.  Fueron incluidos 63 RN con síntomas parvovirales/TORCH y 9 con antecedente de infección materna por B19V confirmada durante el embarazo, atendidos en HUMN-2021-2022, cuyas madres aceptaron participar (con firma de consentimiento). En sangre de cordón y/o periférica se determinó ADN viral mediante biología molecular/PCR y anticuerops específicos IgG e IgM por ELISA. En los casos positivos de RN sintomáticos se investigaron datos clínicos maternos. Entre los RN estudiados por síntomas se incluyeron casos sospechosos/confirmados de Sífilis/VDRL 15, Chagas 3, Toxoplasmosis 5; además hidropesía 3, hiperbilirrubinemia 14, hepatitis/colestasis 5, polihidramnios 2, entre otros (anemia, retardo del crecimiento intrauterino, insuficiencia renal, miocarditis, trastornos de coagulación, hepatoesplenomegalia). En este grupo se identificaron 4/63 (6,3%) RN con infección congénita por B19V: 1/4 con hidropesía y anemia 1/4 con polihidramnios e hiperbilirrubinemia, 1/4 B19V+Sífilis/VDRL materna y 1/4 B19V+Chagas materno. Entre los RN hijos de madres con infección por B19V durante el embarazo, 1/9 presentó infección vertical (con hidropesía feto-neonatal). El síntoma materno más frecuente fue anemia (8/9). En conclusión, se identificaron 4 RN con infección parvoviral y signos clínicos del espectro TORCH durante el periodo estudiado. Además, se confirmó la transmisión vertical en 11% de casos con antecedentes maternos de infección por B19V durante la gestación. La anemia fue el antecedente materno más prevalente y la hidropesía, anemia e hiperbilirrubinemia, la de los RN, por lo que podrían considerarse en el diseño de algoritmos diagnósticos de B19V entre los casos de transmisión vertical del grupo TORCH. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2023-10-19 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/42701 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 80 (2023): Suplemento JIC XXIV Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 80 (2023): Suplemento JIC XXIV Revista da Faculdade de Ciências Médicas de Córdoba; v. 80 (2023): Suplemento JIC XXIV 1853-0605 0014-6722 spa https://revistas.unc.edu.ar/index.php/med/article/view/42701/42887 Derechos de autor 2023 Universidad Nacional de Córdoba http://creativecommons.org/licenses/by-nc/4.0

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