Neoadjuvant breast cancer: statistical and histopathological analysis of tumor response. Casuistry of the National Hospital of Clinics
Breast cancer is a quite prevalent neoplasm in the world, and its treatment has been changing, one of the fundamental pillars being neoadjuvant treatment. It consists of chemotherapy treatment that is administered to reduce the size of the tumor before surgical treatment, thus enhancing the effectiv...
Guardado en:
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Artículo revista |
| Lenguaje: | Español |
| Publicado: |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2023
|
| Materias: | |
| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/42643 |
| Aporte de: |
| id |
I10-R327-article-42643 |
|---|---|
| record_format |
ojs |
| institution |
Universidad Nacional de Córdoba |
| institution_str |
I-10 |
| repository_str |
R-327 |
| container_title_str |
Revista de la Facultad de Ciencias Médicas de Córdoba |
| language |
Español |
| format |
Artículo revista |
| topic |
breast cancer neoadjuvant chemotherapy histopathology carcinoma de mama quimioterapia neoadyuvante histopatología |
| spellingShingle |
breast cancer neoadjuvant chemotherapy histopathology carcinoma de mama quimioterapia neoadyuvante histopatología Anglada , GA Taddei , E Stuppa , T Rosetti , D Cremonezzi, DC Cabalier , MED Romano, SM Alcain, W Neoadjuvant breast cancer: statistical and histopathological analysis of tumor response. Casuistry of the National Hospital of Clinics |
| topic_facet |
breast cancer neoadjuvant chemotherapy histopathology carcinoma de mama quimioterapia neoadyuvante histopatología |
| author |
Anglada , GA Taddei , E Stuppa , T Rosetti , D Cremonezzi, DC Cabalier , MED Romano, SM Alcain, W |
| author_facet |
Anglada , GA Taddei , E Stuppa , T Rosetti , D Cremonezzi, DC Cabalier , MED Romano, SM Alcain, W |
| author_sort |
Anglada , GA |
| title |
Neoadjuvant breast cancer: statistical and histopathological analysis of tumor response. Casuistry of the National Hospital of Clinics |
| title_short |
Neoadjuvant breast cancer: statistical and histopathological analysis of tumor response. Casuistry of the National Hospital of Clinics |
| title_full |
Neoadjuvant breast cancer: statistical and histopathological analysis of tumor response. Casuistry of the National Hospital of Clinics |
| title_fullStr |
Neoadjuvant breast cancer: statistical and histopathological analysis of tumor response. Casuistry of the National Hospital of Clinics |
| title_full_unstemmed |
Neoadjuvant breast cancer: statistical and histopathological analysis of tumor response. Casuistry of the National Hospital of Clinics |
| title_sort |
neoadjuvant breast cancer: statistical and histopathological analysis of tumor response. casuistry of the national hospital of clinics |
| description |
Breast cancer is a quite prevalent neoplasm in the world, and its treatment has been changing, one of the fundamental pillars being neoadjuvant treatment. It consists of chemotherapy treatment that is administered to reduce the size of the tumor before surgical treatment, thus enhancing the effectiveness of surgery and reducing the tumor stage and the likelihood of dissemination or recurrence. The aim of this study is to evaluate the tumor response to neoadjuvant treatment in breast carcinoma surgical specimens removed at the HNC over a period of 46 months, exploring the possible relationship with different histopathological variables and analyzing epidemiological aspects of this pathology in our hospital.
An observational, descriptive, retrospective and cross-sectional study was performed, with nonprobabilistic sampling by convenience, analyzing anatomopathological reports of surgical pieces of quadrantectomies and mastectomies referred to the Anatomic Pathology Service of the HNC, in the period between June 1, 2019 and April 1, 2023, with a diagnosis of invasive carcinoma with previous neoadjuvant therapy. The sample n was 56. The following variables were analyzed: age, laterality, histologic type, histologic grade, molecular subtype, previous tumor size, tumor response grade (Myller and Payne System).
The results showed that the overall response to neoadjuvant therapy was intermediate (MYP 3); the highest percentage of complete response (MYP5) was seen in triple negative (TN) tumors, with histological grades Nottingham 3; left-sided tumors had more complete remission; histological type without differences; previous tumor size and age without significant findings.
Conclusion is that bibliography consulted coincides in relation to most of the variables analyzed, as for instance general distribution of the response grades to neoadyuvancy, and also regarding histological grades 3 and TN subtypes,considered as predicting factors of complete pathological response. Nevertheless an unexpected finding has to do with laterality where it was found that left sided tumors had a greater rate of complete remission contrary to what was described in said bibliography. |
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2023 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/42643 |
| work_keys_str_mv |
AT angladaga neoadjuvantbreastcancerstatisticalandhistopathologicalanalysisoftumorresponsecasuistryofthenationalhospitalofclinics AT taddeie neoadjuvantbreastcancerstatisticalandhistopathologicalanalysisoftumorresponsecasuistryofthenationalhospitalofclinics AT stuppat neoadjuvantbreastcancerstatisticalandhistopathologicalanalysisoftumorresponsecasuistryofthenationalhospitalofclinics AT rosettid neoadjuvantbreastcancerstatisticalandhistopathologicalanalysisoftumorresponsecasuistryofthenationalhospitalofclinics AT cremonezzidc neoadjuvantbreastcancerstatisticalandhistopathologicalanalysisoftumorresponsecasuistryofthenationalhospitalofclinics AT cabaliermed neoadjuvantbreastcancerstatisticalandhistopathologicalanalysisoftumorresponsecasuistryofthenationalhospitalofclinics AT romanosm neoadjuvantbreastcancerstatisticalandhistopathologicalanalysisoftumorresponsecasuistryofthenationalhospitalofclinics AT alcainw neoadjuvantbreastcancerstatisticalandhistopathologicalanalysisoftumorresponsecasuistryofthenationalhospitalofclinics AT angladaga neoadyuvanciaencancerdemamaanalisisestadisticoehistopatologicodelarespuestatumoralcasuisticadelhospitalnacionaldeclinicas AT taddeie neoadyuvanciaencancerdemamaanalisisestadisticoehistopatologicodelarespuestatumoralcasuisticadelhospitalnacionaldeclinicas AT stuppat neoadyuvanciaencancerdemamaanalisisestadisticoehistopatologicodelarespuestatumoralcasuisticadelhospitalnacionaldeclinicas AT rosettid neoadyuvanciaencancerdemamaanalisisestadisticoehistopatologicodelarespuestatumoralcasuisticadelhospitalnacionaldeclinicas AT cremonezzidc neoadyuvanciaencancerdemamaanalisisestadisticoehistopatologicodelarespuestatumoralcasuisticadelhospitalnacionaldeclinicas AT cabaliermed neoadyuvanciaencancerdemamaanalisisestadisticoehistopatologicodelarespuestatumoralcasuisticadelhospitalnacionaldeclinicas AT romanosm neoadyuvanciaencancerdemamaanalisisestadisticoehistopatologicodelarespuestatumoralcasuisticadelhospitalnacionaldeclinicas AT alcainw neoadyuvanciaencancerdemamaanalisisestadisticoehistopatologicodelarespuestatumoralcasuisticadelhospitalnacionaldeclinicas |
| first_indexed |
2024-09-03T21:04:40Z |
| last_indexed |
2024-09-03T21:04:40Z |
| _version_ |
1809210388278935552 |
| spelling |
I10-R327-article-426432023-10-19T21:20:28Z Neoadjuvant breast cancer: statistical and histopathological analysis of tumor response. Casuistry of the National Hospital of Clinics Neoadyuvancia en cáncer de mama: análisis estadístico e histopatológico de la respuesta tumoral. Casuística del Hospital Nacional de Clínicas Anglada , GA Taddei , E Stuppa , T Rosetti , D Cremonezzi, DC Cabalier , MED Romano, SM Alcain, W breast cancer neoadjuvant chemotherapy histopathology carcinoma de mama quimioterapia neoadyuvante histopatología Breast cancer is a quite prevalent neoplasm in the world, and its treatment has been changing, one of the fundamental pillars being neoadjuvant treatment. It consists of chemotherapy treatment that is administered to reduce the size of the tumor before surgical treatment, thus enhancing the effectiveness of surgery and reducing the tumor stage and the likelihood of dissemination or recurrence. The aim of this study is to evaluate the tumor response to neoadjuvant treatment in breast carcinoma surgical specimens removed at the HNC over a period of 46 months, exploring the possible relationship with different histopathological variables and analyzing epidemiological aspects of this pathology in our hospital. An observational, descriptive, retrospective and cross-sectional study was performed, with nonprobabilistic sampling by convenience, analyzing anatomopathological reports of surgical pieces of quadrantectomies and mastectomies referred to the Anatomic Pathology Service of the HNC, in the period between June 1, 2019 and April 1, 2023, with a diagnosis of invasive carcinoma with previous neoadjuvant therapy. The sample n was 56. The following variables were analyzed: age, laterality, histologic type, histologic grade, molecular subtype, previous tumor size, tumor response grade (Myller and Payne System). The results showed that the overall response to neoadjuvant therapy was intermediate (MYP 3); the highest percentage of complete response (MYP5) was seen in triple negative (TN) tumors, with histological grades Nottingham 3; left-sided tumors had more complete remission; histological type without differences; previous tumor size and age without significant findings. Conclusion is that bibliography consulted coincides in relation to most of the variables analyzed, as for instance general distribution of the response grades to neoadyuvancy, and also regarding histological grades 3 and TN subtypes,considered as predicting factors of complete pathological response. Nevertheless an unexpected finding has to do with laterality where it was found that left sided tumors had a greater rate of complete remission contrary to what was described in said bibliography. El cáncer de mama es una neoplasia muy prevalente en el mundo, y su tratamiento se ha ido modificando, siendo uno de los pilares fundamentales la neoadyuvancia. Consta de tratamiento quimioterápico que se administra para reducir el tamaño tumoral antes del tratamiento quirúrgico, y así potenciar la efectividad de la cirugía y disminuir el estadio tumoral y las probabilidades de diseminación o recurrencia. El objetivo del trabajo es evaluar la respuesta tumoral a la neoadyuvancia en las piezas quirúrgicas de mamas con carcinoma, extirpadas en el HNC en un período de 46 meses, explorando la posible relación con diferentes variables histopatológicas y analizando aspectos epidemiológicos sobre esta patología en nuestro hospital. Se realizó un estudio observacional, descriptivo, retrospectivo y transversal, con muestreo no probabilístico por conveniencia, analizando informes anatomopatológicos de piezas quirúrgicas de cuadrantectomías y mastectomías remitidas al Servicio de Anatomía Patológica del HNC, en el período comprendido entre el 1 de junio de 2019 y el 1 de abril de 2023, con diagnóstico de carcinoma invasor con terapia neoadyuvante previa. El n muestral fue de 56. Se analizaron las variables: edad, lateralidad, tipo histológico, grado histológico, subtipo molecular, tamaño tumoral previo, grado de respuesta tumoral (Sistema Myller y Payne). Los resultados mostraron que la respuesta global a la neoadyuvancia fue intermedia (MYP 3); el mayor porcentaje de respuesta completa (MYP5) se vio en los tumores triple negativo (TN), con grados histológicos Nottingham 3; los tumores del lado izquierdo tuvieron más remisión completa; tipo histológico sin diferencias; tamaño tumoral previo y edad sin hallazgos significativos. Se concluye que hubo concordancia con la bibliografía consultada en relación a la mayoría de las variables analizadas, como distribución general de los grados de respuesta a la neoadyuvancia, y, en los grados histológicos 3 y subtipos TN, como factores predictores de respuesta patológica completa. Un hallazgo inesperado tiene que ver con la lateralidad, donde encontramos que los tumores del lado izquierdo tuvieron mayor tasa de remisión completa, contrario a lo descripto en la bibliografía. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2023-10-19 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/42643 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 80 (2023): Suplemento JIC XXIV Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 80 (2023): Suplemento JIC XXIV Revista da Faculdade de Ciências Médicas de Córdoba; v. 80 (2023): Suplemento JIC XXIV 1853-0605 0014-6722 spa https://revistas.unc.edu.ar/index.php/med/article/view/42643/42847 Derechos de autor 2023 Universidad Nacional de Córdoba http://creativecommons.org/licenses/by-nc/4.0 |