Predictive value of C-reactive protein on hospital admission and mechanical ventilation requirement in adults hospitalized for COVID-19
Introduction: During the COVID-19 pandemic, patients with worse evolution presented clinical deterioration 7-10 days after the onset of symptoms, which suggests that the inflammatory response could participate in the pathophysiology of the disease. The objective of this study was to evaluate the ass...
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| Autores principales: | , , , |
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| Formato: | Artículo revista |
| Lenguaje: | Español |
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2024
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/41799 |
| Aporte de: |
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I10-R327-article-41799 |
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ojs |
| institution |
Universidad Nacional de Córdoba |
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I-10 |
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R-327 |
| container_title_str |
Revista de la Facultad de Ciencias Médicas de Córdoba |
| language |
Español |
| format |
Artículo revista |
| topic |
COVID-19 Reactive C protein; mechanical ventilation PCR COVID-19 PCR ventilación mecánica proteína c-reactiva COVID-19 PCR ultrassensível; respiração artificial proteína c-reativa |
| spellingShingle |
COVID-19 Reactive C protein; mechanical ventilation PCR COVID-19 PCR ventilación mecánica proteína c-reactiva COVID-19 PCR ultrassensível; respiração artificial proteína c-reativa Guidetto, Betiana Alejandra Fonseca , Sebastian Abrate, Alejandro Martin Politi, Maria Teresa Predictive value of C-reactive protein on hospital admission and mechanical ventilation requirement in adults hospitalized for COVID-19 |
| topic_facet |
COVID-19 Reactive C protein; mechanical ventilation PCR COVID-19 PCR ventilación mecánica proteína c-reactiva COVID-19 PCR ultrassensível; respiração artificial proteína c-reativa |
| author |
Guidetto, Betiana Alejandra Fonseca , Sebastian Abrate, Alejandro Martin Politi, Maria Teresa |
| author_facet |
Guidetto, Betiana Alejandra Fonseca , Sebastian Abrate, Alejandro Martin Politi, Maria Teresa |
| author_sort |
Guidetto, Betiana Alejandra |
| title |
Predictive value of C-reactive protein on hospital admission and mechanical ventilation requirement in adults hospitalized for COVID-19 |
| title_short |
Predictive value of C-reactive protein on hospital admission and mechanical ventilation requirement in adults hospitalized for COVID-19 |
| title_full |
Predictive value of C-reactive protein on hospital admission and mechanical ventilation requirement in adults hospitalized for COVID-19 |
| title_fullStr |
Predictive value of C-reactive protein on hospital admission and mechanical ventilation requirement in adults hospitalized for COVID-19 |
| title_full_unstemmed |
Predictive value of C-reactive protein on hospital admission and mechanical ventilation requirement in adults hospitalized for COVID-19 |
| title_sort |
predictive value of c-reactive protein on hospital admission and mechanical ventilation requirement in adults hospitalized for covid-19 |
| description |
Introduction: During the COVID-19 pandemic, patients with worse evolution presented clinical deterioration 7-10 days after the onset of symptoms, which suggests that the inflammatory response could participate in the pathophysiology of the disease. The objective of this study was to evaluate the association between plasma C-reactive protein (PCr) on hospital admission and mechanical ventilation requirement during hospitalization in adults with COVID-19.
Methods: Retrospective, observational cohort at a private center in the province of Buenos Aires. Hospitalized adults diagnosed with COVID-19 by nasal swab using real time transcription polymerase chain reaction or antigen were included. The primary outcome was the association between high plasma PCr values on hospital admission (≥8 mg/L) and mechanical ventilation requirement during hospitalization.
Results: Of the 1,242 patients enrolled, 19.4% required mechanical ventilation and 11.7% died during the hospitalization. The PCr of the patients who required mechanical ventilation was higher than that of those who did not require mechanical ventilation (9.45 [5.20-18.70] mg/L vs 4.95 [1.80-10.70] mg/L; p < 0.01). PCr analyzed as a continuous variable (OR = 1.39; 95%CI 1.21-1.60; p < 0.001) and as a categorical variable (≥8 mg/L) (OR = 2.66; 95%CI 2.19 -3.78, p < 0.001) presented a significant association with the requirement of mechanical ventilation during hospitalization. Additionally, a significant association was found between PCr and in-hospital mortality.
Conclusion: Plasma PCr on hospital admission could predict clinical evolution in adult patients hospitalized for COVID-19. |
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2024 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/41799 |
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2024-09-03T21:04:33Z |
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I10-R327-article-417992024-04-30T15:20:08Z Predictive value of C-reactive protein on hospital admission and mechanical ventilation requirement in adults hospitalized for COVID-19 Valor predictivo de proteína C reactiva al ingreso sanatorial y requerimiento de asistencia respiratoria mecánica en adultos internados por COVID-19 Valor preditivo da proteína C-reativa na admissão hospitalar e necessidade de assistência respiratória mecânica em adultos hospitalizados por COVID-19 Guidetto, Betiana Alejandra Fonseca , Sebastian Abrate, Alejandro Martin Politi, Maria Teresa COVID-19 Reactive C protein; mechanical ventilation PCR COVID-19 PCR ventilación mecánica proteína c-reactiva COVID-19 PCR ultrassensível; respiração artificial proteína c-reativa Introduction: During the COVID-19 pandemic, patients with worse evolution presented clinical deterioration 7-10 days after the onset of symptoms, which suggests that the inflammatory response could participate in the pathophysiology of the disease. The objective of this study was to evaluate the association between plasma C-reactive protein (PCr) on hospital admission and mechanical ventilation requirement during hospitalization in adults with COVID-19. Methods: Retrospective, observational cohort at a private center in the province of Buenos Aires. Hospitalized adults diagnosed with COVID-19 by nasal swab using real time transcription polymerase chain reaction or antigen were included. The primary outcome was the association between high plasma PCr values on hospital admission (≥8 mg/L) and mechanical ventilation requirement during hospitalization. Results: Of the 1,242 patients enrolled, 19.4% required mechanical ventilation and 11.7% died during the hospitalization. The PCr of the patients who required mechanical ventilation was higher than that of those who did not require mechanical ventilation (9.45 [5.20-18.70] mg/L vs 4.95 [1.80-10.70] mg/L; p < 0.01). PCr analyzed as a continuous variable (OR = 1.39; 95%CI 1.21-1.60; p < 0.001) and as a categorical variable (≥8 mg/L) (OR = 2.66; 95%CI 2.19 -3.78, p < 0.001) presented a significant association with the requirement of mechanical ventilation during hospitalization. Additionally, a significant association was found between PCr and in-hospital mortality. Conclusion: Plasma PCr on hospital admission could predict clinical evolution in adult patients hospitalized for COVID-19. Introducción: Durante la pandemia por COVID-19, los pacientes con peor evolución presentaron deterioro clínico a los 7-10 días del inicio de síntomas, lo cual sugiere que la respuesta inflamatoria podría participar de la fisiopatogenia de la enfermedad. El objetivo de este estudio fue evaluar la asociación entre los valores de proteína C reactiva (PCr) en plasma al ingreso sanatorial en adultos con COVID-19 y el requerimiento de asistencia respiratoria mecánica (ARM) durante la internación. Métodos: Cohorte retrospectiva, observacional, en un centro privado de la provincia de Buenos Aires. Se incluyeron a adultos internados con diagnóstico de COVID-19 por hisopado nasal, mediante real time transcription polymerasa chain reaction o antígeno. El desenlace primario fue la asociación entre valores altos de PCr en plasma al ingreso sanatorial (≥8 mg/L) y el requerimiento de ARM durante la internación. Resultados: De los 1.242 pacientes enrolados, 19,4% requirieron ARM y 11,7% fallecieron durante la internación. La PCr de los pacientes que requirieron ARM fue mayor que la de los que no la requirieron (9,45 [5,20-18,70] mg/L vs 4,95 [1,80-10,70] mg/L; p < 0,01). La PCr analizada como variable continua (OR = 1,39; IC95% 1,21-1,60; p < 0,001) y como variable categórica (≥8 mg/L) (OR = 2,66; IC95% 2,19-3,78; p < 0,001) presentó una asociación significativa con el requerimiento de ARM durante la internación. Secundariamente, se encontró una asociación significativa entre PCr y mortalidad intrahospitalaria. Conclusión: El valor de PCr en plasma al ingreso sanatorial podría predecir la evolución clínica en pacientes adultos internados por COVID-19. Introdução: Durante a pandemia de COVID-19, os pacientes apresentaram uma piora clínica de 7-10 dias após o início dos sintomas, o que sugere que a resposta inflamatória poderia participar da fisiopatologia da doença. O objetivo deste estudo foi avaliar a associação entre os valores de proteína C reativa (PCr) plasmática na admissão hospitalar em adultos com COVID-19 e a necessidade de ventilação mecânica durante a internação. Métodos: Corte observacional retrospectiva em um centro privado na província de Buenos Aires. Foram incluídos adultos hospitalizados com diagnóstico de COVID-19 por swab nasal, usando reação em cadeia da polimerase com transcrição em tempo real ou antígeno. O desfecho primário foi a associação entre altos valores plasmáticos de PCr na admissão hospitalar (≥8 mg/L) e a necessidade de ventilação mecânica durante a internação. Resultados: Os 1.242 pacientes inscritos, 19,4% necessitaram de MRA e 11,7% morreram durante a internação. A PCr dos pacientes que necessitaram de ventilação mecânica foi maior do que a daqueles que não necessitaram (9,45 [5,20-18,70] mg/L vs 4,95 [1,80-10,70] mg/L; p < 0,01). PCr analisa como variável continua (OR = 1,39; IC 95% 1,21-1,60; p < 0,001) e como variável categórica (≥8 mg/L) (OR = 2,66; IC 95% 2,19 -3,78, p < 0,001) apresentou associação significativa com a necessidade de ventilação mecânica durante a internação. Secundariamente, foi encontrada associação significativa entre PCR e mortalidade intra-hospitalar. Conclusão: O valor plasmático de PCr na admissão hospitalar pode predizer a evolução clínica em pacientes adultos internados por COVID-19. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2024-03-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion text/html application/pdf application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/41799 10.31053/1853.0605.v81.n1.41799 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 81 No. 1 (2024); 67-82 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 81 Núm. 1 (2024); 67-82 Revista da Faculdade de Ciências Médicas de Córdoba; v. 81 n. 1 (2024); 67-82 1853-0605 0014-6722 10.31053/1853.0605.v81.n1 spa https://revistas.unc.edu.ar/index.php/med/article/view/41799/44970 https://revistas.unc.edu.ar/index.php/med/article/view/41799/44759 https://revistas.unc.edu.ar/index.php/med/article/view/41799/44760 Derechos de autor 2024 Universidad Nacional de Córdoba http://creativecommons.org/licenses/by-nc/4.0 |