High frequency of hepatitis E virus antibody detection in pigs from farms in Córdoba province
The infection caused by the hepatitis E virus (HEV) is a common cause of acute viral hepatitis worldwide. HEV genotypes 3 (HEV-3) and 4 (HEV-4) are zoonotic and predominant in pig and wild boar populations, which act as reservoirs. HEV can be transmitted from these animals to humans through the cons...
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| Formato: | Artículo revista |
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2022
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/39156 |
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I10-R327-article-39156 |
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ojs |
| institution |
Universidad Nacional de Córdoba |
| institution_str |
I-10 |
| repository_str |
R-327 |
| container_title_str |
Revista de la Facultad de Ciencias Médicas de Córdoba |
| format |
Artículo revista |
| topic |
HEV antibody detection pigs córdoba province HEV detección serológica cerdos provincia de Córdoba |
| spellingShingle |
HEV antibody detection pigs córdoba province HEV detección serológica cerdos provincia de Córdoba Di Cola , GU Di Cola , GA Mamani, V Martínez Wassaf, MG Pisano, MB Ré, VE High frequency of hepatitis E virus antibody detection in pigs from farms in Córdoba province |
| topic_facet |
HEV antibody detection pigs córdoba province HEV detección serológica cerdos provincia de Córdoba |
| author |
Di Cola , GU Di Cola , GA Mamani, V Martínez Wassaf, MG Pisano, MB Ré, VE |
| author_facet |
Di Cola , GU Di Cola , GA Mamani, V Martínez Wassaf, MG Pisano, MB Ré, VE |
| author_sort |
Di Cola , GU |
| title |
High frequency of hepatitis E virus antibody detection in pigs from farms in Córdoba province |
| title_short |
High frequency of hepatitis E virus antibody detection in pigs from farms in Córdoba province |
| title_full |
High frequency of hepatitis E virus antibody detection in pigs from farms in Córdoba province |
| title_fullStr |
High frequency of hepatitis E virus antibody detection in pigs from farms in Córdoba province |
| title_full_unstemmed |
High frequency of hepatitis E virus antibody detection in pigs from farms in Córdoba province |
| title_sort |
high frequency of hepatitis e virus antibody detection in pigs from farms in córdoba province |
| description |
The infection caused by the hepatitis E virus (HEV) is a common cause of acute viral hepatitis worldwide. HEV genotypes 3 (HEV-3) and 4 (HEV-4) are zoonotic and predominant in pig and wild boar populations, which act as reservoirs. HEV can be transmitted from these animals to humans through the consumption of contaminated derived products or by direct contact with infected animals. Therefore, the research of zoonotic pathogens aims to safeguard human and animal health and ensure safe food. In Argentina, HEV circulation in pigs, wild boars, environmental matrices, and sporadic cases in humans have been reported. The objective of the study was to determine the frequency of HEV antibody detection in pig farms in Córdoba province.
The presence of total anti-HEV antibodies was analyzed by ELISA (HEV Ab Ultra, Diapro) in 276 sera from pigs between 3 and 6 months of age. The samples were obtained from 37 farms for food production, belonging to 9 departments of the province of Córdoba (50% of them were in the department of Río Cuarto) and were collected from June to September/2019 (n=178) and October to December/2020 (n=98). To assess association, Pearson's χ² tests were performed and a value of p<0.05 was used as the criterion of statistical significance.
The global detection frequency was 80.1% (221/276), being similar in both periods (79.2% vs 81.6%; p=0.63) and between the departments studied (range: 73.6% -100%, p=0.20). From the total farms analyzed, 91.9% (34/37) had animals with anti-HEV antibodies.
A high frequency of anti-HEV antibodies was detected in pigs from Córdoba, with a homogeneous distribution throughout the province, coinciding with previous studies in other regions of the country. Seropositivity in young pigs indicates an early exposure to HEV, and positions them as a viral reservoir and possible source of infection for the exposed population, both animals and humans (by direct contact or consumption of raw or undercooked meat from infected animals). These studies will continue to broaden the results and investigate the presence of the virus in pig-derived foods. |
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2022 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/39156 |
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I10-R327-article-391562024-04-15T16:14:45Z High frequency of hepatitis E virus antibody detection in pigs from farms in Córdoba province Elevada frecuencia de detección de anticuerpos para el virus de hepatitis E en cerdos de granjas de la provincia de Córdoba Di Cola , GU Di Cola , GA Mamani, V Martínez Wassaf, MG Pisano, MB Ré, VE HEV antibody detection pigs córdoba province HEV detección serológica cerdos provincia de Córdoba The infection caused by the hepatitis E virus (HEV) is a common cause of acute viral hepatitis worldwide. HEV genotypes 3 (HEV-3) and 4 (HEV-4) are zoonotic and predominant in pig and wild boar populations, which act as reservoirs. HEV can be transmitted from these animals to humans through the consumption of contaminated derived products or by direct contact with infected animals. Therefore, the research of zoonotic pathogens aims to safeguard human and animal health and ensure safe food. In Argentina, HEV circulation in pigs, wild boars, environmental matrices, and sporadic cases in humans have been reported. The objective of the study was to determine the frequency of HEV antibody detection in pig farms in Córdoba province. The presence of total anti-HEV antibodies was analyzed by ELISA (HEV Ab Ultra, Diapro) in 276 sera from pigs between 3 and 6 months of age. The samples were obtained from 37 farms for food production, belonging to 9 departments of the province of Córdoba (50% of them were in the department of Río Cuarto) and were collected from June to September/2019 (n=178) and October to December/2020 (n=98). To assess association, Pearson's χ² tests were performed and a value of p<0.05 was used as the criterion of statistical significance. The global detection frequency was 80.1% (221/276), being similar in both periods (79.2% vs 81.6%; p=0.63) and between the departments studied (range: 73.6% -100%, p=0.20). From the total farms analyzed, 91.9% (34/37) had animals with anti-HEV antibodies. A high frequency of anti-HEV antibodies was detected in pigs from Córdoba, with a homogeneous distribution throughout the province, coinciding with previous studies in other regions of the country. Seropositivity in young pigs indicates an early exposure to HEV, and positions them as a viral reservoir and possible source of infection for the exposed population, both animals and humans (by direct contact or consumption of raw or undercooked meat from infected animals). These studies will continue to broaden the results and investigate the presence of the virus in pig-derived foods. La infección causada por el virus de hepatitis E (HEV) es una causa frecuente de hepatitis viral aguda en todo el mundo. Los genotipos HEV-3 y 4 son zoonóticos, y predominantes en poblaciones de cerdos y jabalíes, que actúan como reservorios. El HEV puede transmitirse desde estos animales al hombre, mediante el consumo de productos derivados contaminados o por contacto directo con animales infectados. Por lo tanto, la investigación de patógenos zoonóticos tiene como objetivo salvaguardar la salud humana y animal y garantizar alimentos seguros. En Argentina, se ha reportado circulación viral en cerdos, jabalíes, matrices ambientales y casos esporádicos en humanos. El objetivo del estudio fue determinar la frecuencia de detección de HEV en granjas porcinas de la provincia Córdoba. Se analizó la presencia de anticuerpos totales anti-HEV por la técnica de ELISA (HEV Ab Ultra, Diapro) en 276 sueros de cerdos de entre 3 y 6 meses de edad, obtenidos de 37 criaderos de animales para faena y producción de alimentos, pertenecientes a 9 departamentos de la provincia de Córdoba (el 50% de ellos se encontraba en el departamento de Río Cuarto), recolectadas durante junio a septiembre/2019 (n=178) y octubre a diciembre/2020 (n=98). Para evaluar asociación se realizaron pruebas χ² de Pearson, tomando un valor de p<0,05 como criterio de significancia estadística. La frecuencia de detección global fue 80,1% (221/276), siendo similar en ambos periodos (79,2% vs 81,6%; p=0,63) y entre los departamentos estudiados (rango: 73,6%-100%; p=0,20). Del total de granjas analizadas, el 91,9% (34/37) albergaban animales con anticuerpos anti-HEV. Se detectó alta frecuencia de detección de anticuerpos anti-HEV en cerdos de Córdoba, con una distribución homogénea en toda la provincia, coincidiendo con estudios previos en otras regiones del país. La seropositividad en cerdos de corta edad indica su temprana exposición al HEV, y los posiciona como reservorio viral y posible fuente de infección a población expuesta, tanto animal, como humana (por contacto directo o consumo de carne cruda o poco cocida proveniente de animales infectados). Se continuará con estos estudios a fin de ampliar los resultados e investigar la presencia del virus en alimentos derivados porcinos. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2022-10-26 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion texto texto texto https://revistas.unc.edu.ar/index.php/med/article/view/39156 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 79 No. Suplemento JIC XXIII (2022): Suplemento JIC XXIII Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 79 Núm. Suplemento JIC XXIII (2022): Suplemento JIC XXIII Revista da Faculdade de Ciências Médicas de Córdoba; v. 79 n. Suplemento JIC XXIII (2022): Suplemento JIC XXIII 1853-0605 0014-6722 http://creativecommons.org/licenses/by-nc/4.0 |