Idiopathic inflammatory myopathy-related interstitial lung disease: multicentric study in Córdoba
Interstitial lung disease (ILD) is one of the most frequent systemic complications of idiopathic inflammatory myopathies (IIM). However, there is limited knowledge about this disorder. The purpose of the present work was to describe the clinical, radiological, and pulmonary function of patients...
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| Formato: | Artículo revista |
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2022
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/39104 |
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I10-R327-article-39104 |
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ojs |
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Universidad Nacional de Córdoba |
| institution_str |
I-10 |
| repository_str |
R-327 |
| container_title_str |
Revista de la Facultad de Ciencias Médicas de Córdoba |
| format |
Artículo revista |
| topic |
interstitial lung disease idiopathic inflammatory myopathy anti-Jo1 enfermedad pulmonar intersticial miopatías autoinmunes anticuerpos anti-Jo1 |
| spellingShingle |
interstitial lung disease idiopathic inflammatory myopathy anti-Jo1 enfermedad pulmonar intersticial miopatías autoinmunes anticuerpos anti-Jo1 Nigra, N Savio, V Farrel, P Tissera, Y Cuestas, E Uribe Echeverria , M Alba Moreyra , P Moyano, V Idiopathic inflammatory myopathy-related interstitial lung disease: multicentric study in Córdoba |
| topic_facet |
interstitial lung disease idiopathic inflammatory myopathy anti-Jo1 enfermedad pulmonar intersticial miopatías autoinmunes anticuerpos anti-Jo1 |
| author |
Nigra, N Savio, V Farrel, P Tissera, Y Cuestas, E Uribe Echeverria , M Alba Moreyra , P Moyano, V |
| author_facet |
Nigra, N Savio, V Farrel, P Tissera, Y Cuestas, E Uribe Echeverria , M Alba Moreyra , P Moyano, V |
| author_sort |
Nigra, N |
| title |
Idiopathic inflammatory myopathy-related interstitial lung disease: multicentric study in Córdoba |
| title_short |
Idiopathic inflammatory myopathy-related interstitial lung disease: multicentric study in Córdoba |
| title_full |
Idiopathic inflammatory myopathy-related interstitial lung disease: multicentric study in Córdoba |
| title_fullStr |
Idiopathic inflammatory myopathy-related interstitial lung disease: multicentric study in Córdoba |
| title_full_unstemmed |
Idiopathic inflammatory myopathy-related interstitial lung disease: multicentric study in Córdoba |
| title_sort |
idiopathic inflammatory myopathy-related interstitial lung disease: multicentric study in córdoba |
| description |
Interstitial lung disease (ILD) is one of the most frequent systemic complications of idiopathic inflammatory myopathies (IIM). However, there is limited knowledge about this disorder. The purpose of the present work was to describe the clinical, radiological, and pulmonary function of patients with idiopathic inflammatory myopathy-related interstitial lung disease.
We conducted a retrospective studied with patients with diagnosis of IIM by ARC/EULAR 2017 in 3 rheumatology Units at Córdoba between 2017 and 2021. Demographic data, type of myopathy, clinical manifestations, autoantibody profile, pulmonary function, and tomographic patterns were analyzed. Quantitative variables were expressed as mean and standard deviation. Categorical variables were calculated using absolute and percentage distributions. The Kruskal Wallis test was applied in the comparison of means (after applying the Shapiro Wilks normality test) and the chi-square test in the correlation of categorical variables. p≤0.05 was considered significant.
We included 47 patients, 26 with ILD (55.3%). In this subgroup, the mean age was 48.3 years, 80.8% were female and 23.1% were smokers. 84.6% had dyspnea and 50% cough. 50% had muscle weakness. Median FVC was 62.2% and median DLCO was 52.5% of predicted. 50% of the patients had oxygen desaturation during the 6-minute walk test. The predominant tomographic pattern was NSIP (57.7%), followed by UIP (34.6%). The most frequent specific autoantibodies were: Jo-1 (38.5%), AMA (7.7%), Pm ScL100(4%) and SRP (4%). ANA was positive at 26.9%. Regarding antibodies associated with myositis, 7.7% had Ro (+) and 3.8% RNP (+). Patients with ILD had more frequency of antisynthetase syndrome (46.2% vs 0%; p=0.0008), respiratory manifestations (dyspnea 84.6% vs 14.3%; p=0.0001, cough 50.0% vs 14.3%; p=0.013) and anti-Jo1(+) (38.5% vs 14.3%; p=0.042) compared to those without lung involvement.
In our cohort of patients with ILD associated with autoimmune inflammatory myopathies had more frequent positive anti-Jo1 antibody, tomographic pattern of NSIP, and restrictive pulmonary function.
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| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2022 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/39104 |
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2024-09-03T21:04:14Z |
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I10-R327-article-391042024-04-15T16:14:45Z Idiopathic inflammatory myopathy-related interstitial lung disease: multicentric study in Córdoba Enfermedad pulmonar intersticial asociada a miopatías de origen autoinmune: estudio multicéntrico en Córdoba Nigra, N Savio, V Farrel, P Tissera, Y Cuestas, E Uribe Echeverria , M Alba Moreyra , P Moyano, V interstitial lung disease idiopathic inflammatory myopathy anti-Jo1 enfermedad pulmonar intersticial miopatías autoinmunes anticuerpos anti-Jo1 Interstitial lung disease (ILD) is one of the most frequent systemic complications of idiopathic inflammatory myopathies (IIM). However, there is limited knowledge about this disorder. The purpose of the present work was to describe the clinical, radiological, and pulmonary function of patients with idiopathic inflammatory myopathy-related interstitial lung disease. We conducted a retrospective studied with patients with diagnosis of IIM by ARC/EULAR 2017 in 3 rheumatology Units at Córdoba between 2017 and 2021. Demographic data, type of myopathy, clinical manifestations, autoantibody profile, pulmonary function, and tomographic patterns were analyzed. Quantitative variables were expressed as mean and standard deviation. Categorical variables were calculated using absolute and percentage distributions. The Kruskal Wallis test was applied in the comparison of means (after applying the Shapiro Wilks normality test) and the chi-square test in the correlation of categorical variables. p≤0.05 was considered significant. We included 47 patients, 26 with ILD (55.3%). In this subgroup, the mean age was 48.3 years, 80.8% were female and 23.1% were smokers. 84.6% had dyspnea and 50% cough. 50% had muscle weakness. Median FVC was 62.2% and median DLCO was 52.5% of predicted. 50% of the patients had oxygen desaturation during the 6-minute walk test. The predominant tomographic pattern was NSIP (57.7%), followed by UIP (34.6%). The most frequent specific autoantibodies were: Jo-1 (38.5%), AMA (7.7%), Pm ScL100(4%) and SRP (4%). ANA was positive at 26.9%. Regarding antibodies associated with myositis, 7.7% had Ro (+) and 3.8% RNP (+). Patients with ILD had more frequency of antisynthetase syndrome (46.2% vs 0%; p=0.0008), respiratory manifestations (dyspnea 84.6% vs 14.3%; p=0.0001, cough 50.0% vs 14.3%; p=0.013) and anti-Jo1(+) (38.5% vs 14.3%; p=0.042) compared to those without lung involvement. In our cohort of patients with ILD associated with autoimmune inflammatory myopathies had more frequent positive anti-Jo1 antibody, tomographic pattern of NSIP, and restrictive pulmonary function. Las enfermedades pulmonares intersticiales difusas (EPID) son una de las complicaciones sistémicas más frecuentes de las miopatías inflamatorias (MII). Existe escasa información respecto a la asociación de las mismas. Objetivo: Describir las características clínicas, radiológicas y funcionales respiratorias en pacientes con EPID asociada a miopatías inflamatorias autoinmunes. Se realizó un estudio observacional, descriptivo, retrospectivo, multicéntrico, pacientes con MII (ARC/EULAR 2017), de 3 centros de Córdoba. Período 2017-2021. Se analizaron variables demográficas, tipo de miopatía, manifestaciones clínicas, serología autoinmune, pruebas funcionales respiratorias y patrones tomográficos. Para las variables cuantitativas se calcularon media y desvío estándar. variables categóricas calculadas mediante distribuciones absolutas y porcentuales. Se aplicaron test de Kruskal Wallis en la comparación de medias (previa aplicación de test de normalidad de Shapiro Wilks) y test de chi-cuadrado en la correlación de variables categóricas. Nivel de significancia igual a 0,05. Se reclutaron 47 pacientes, 26 con EPID (55,3%). En este subgrupo, la edad media fue de 48,3 años, con predominio femenino (80,8%). El 23,1% eran fumadores. Presentaron disnea un 84,6%, tos 50%, debilidad muscular 50%. La FVC media fue 62,2% del predicho y la DLCO 52.5%. El 50% de los individuos presentó desaturación de oxígeno durante el test de la caminata. El patrón tomográfico predominante fue NINE (57.7%), seguido por NIU (34,6%) y en un 7,7% inespecífico. El anticuerpo más frecuente fue Jo 1 (38,5%), ANA(+) 26,9%, AMA(+) 7,7%, Pm ScL100 y SRP 4%. De los anticuerpos asociados a miositis (MAA), 7,7% Ro(+) y 3.8% RNP(+). Los pacientes con EPID presentaron más frecuentemente síndrome antisintetasa (46,2%vs0%; p=0.0008), manifestaciones respiratorias (disnea 84,6%vs14,3%; p=0,0001, tos 50,0%vs14,3%; p=0,013) y anti-Jo1(+) (38,5%v14,3%; p=0.042) respecto a los que no presentaban compromiso pulmonar. En nuestra cohorte de pacientes con EPID asociada a miopatías inflamatorias autoinmunes de Córdoba, predominan las mujeres de edad media, con perfil autoinmune anti-Jo1 positivo, patrón tomográfico de NINE y compromiso funcional pulmonar restrictivo. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2022-10-26 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion texto https://revistas.unc.edu.ar/index.php/med/article/view/39104 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 79 No. Suplemento JIC XXIII (2022): Suplemento JIC XXIII Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 79 Núm. Suplemento JIC XXIII (2022): Suplemento JIC XXIII Revista da Faculdade de Ciências Médicas de Córdoba; v. 79 n. Suplemento JIC XXIII (2022): Suplemento JIC XXIII 1853-0605 0014-6722 http://creativecommons.org/licenses/by-nc/4.0 |