Uncommon breast tumors. A report of four cases
Breast cancer is the most common malignancy and the second leading cause of cancer mortality in women, forcing the determination of an early and accurate diagnosis. There are also other uncommon neoplastic lesions. On account that many of them have different prognosis and treatment, it is impor...
| Autores principales: | , , , , |
|---|---|
| Formato: | Artículo revista |
| Publicado: |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2022
|
| Materias: | |
| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/39103 |
| Aporte de: |
| id |
I10-R327-article-39103 |
|---|---|
| record_format |
ojs |
| institution |
Universidad Nacional de Córdoba |
| institution_str |
I-10 |
| repository_str |
R-327 |
| container_title_str |
Revista de la Facultad de Ciencias Médicas de Córdoba |
| format |
Artículo revista |
| topic |
breast liposarcoma angiosarcoma myofibroblastoma adenomyoepithelioma MAMA liposarcoma angiosarcoma miofibroblastoma adenomioepitelioma |
| spellingShingle |
breast liposarcoma angiosarcoma myofibroblastoma adenomyoepithelioma MAMA liposarcoma angiosarcoma miofibroblastoma adenomioepitelioma Taddei, E Ferro, AA Szlabi, S Rosetti, D Cremonezzi, DC Uncommon breast tumors. A report of four cases |
| topic_facet |
breast liposarcoma angiosarcoma myofibroblastoma adenomyoepithelioma MAMA liposarcoma angiosarcoma miofibroblastoma adenomioepitelioma |
| author |
Taddei, E Ferro, AA Szlabi, S Rosetti, D Cremonezzi, DC |
| author_facet |
Taddei, E Ferro, AA Szlabi, S Rosetti, D Cremonezzi, DC |
| author_sort |
Taddei, E |
| title |
Uncommon breast tumors. A report of four cases |
| title_short |
Uncommon breast tumors. A report of four cases |
| title_full |
Uncommon breast tumors. A report of four cases |
| title_fullStr |
Uncommon breast tumors. A report of four cases |
| title_full_unstemmed |
Uncommon breast tumors. A report of four cases |
| title_sort |
uncommon breast tumors. a report of four cases |
| description |
Breast cancer is the most common malignancy and the second leading cause of cancer mortality in women, forcing the determination of an early and accurate diagnosis. There are also other uncommon neoplastic lesions. On account that many of them have different prognosis and treatment, it is important to differentiate them. The objective of this work is to interpret the morphology of 4 cases of exceptional presentation, in order to consider them in medical practice.
Case 1: 30yo woman, tumor in right upper-outer quadrant. Biopsy: compatible with signet-ring cell carcinoma. In 6mo it grew considerably and a simple mastectomy was performed. We observed a whitish and ulcerated tumor of 24x22x8 cm. Microscopy: mesenchymal neoplasm, marked anisokaryosis, vacuolated cytoplasm, bizarre nuclei, increased mitoses, necrosis, and ulcerated skin. Triple-negative, Ki-67 30%. Diagnosis: Primary pleomorphic liposarcoma.
Case 2: 63yo woman with a left painless multinodular mass. Simple mastectomy. Intraoperative biopsy: myxoid spindle cell lesion. Macroscopy: 25 cm tumor, lobulated and pseudoencapsulated. Cut surface is solid, grayish, with mucinous areas and necrohemorrhagic foci. Microscopy: spindle cells, clear cytoplasms, small, hyperchromatic nuclei, inconspicuous nucleoli, nuclear pseudoinclusions, myxoid background, collagenous areas, scarce mitoses. CD34(+), ASMA(+), Ki-67 15%. Diagnosis: Breast myofibroblastoma.
Case 3: 82yo woman with a verruciform mass on the skin of the right breast. Macroscopy: 1.4x1x0.9 cm lesion, reddish brown, well-defined borders. At the surgical limit, another elevated lesion is observed, 1.3x9x0.5 cm, whitish, ulcerated. Microscopy: dermis with atypical neoplastic endothelial cells, forming dilated vessels and papillae, Others are spindle-shaped and epithelioid. Diagnosis: High grade angiosarcoma.
Case 4: 42yo woman, right painless palpable mass. Quadrantectomy. Macroscopy: 0.6 cm multilobulated, irregular, whitish lesion with central cystification. Microscopy: lobular tubulo-epithelial structures surrounded by basal and interstitial myoepithelial cells with clear, polygonal, and fused cytoplasm. p63(+), Actin(+), Vimentin(+), low Ki-67. Diagnosis: lobulated adenomyoepithelioma
Uncommon cases of neoplasms require specific morphological criteria and resolution with immunohistochemical techniques in most cases. Diagnoses must be confirmed with histopathological study and eventually with immunohytochemistry.
|
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2022 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/39103 |
| work_keys_str_mv |
AT taddeie uncommonbreasttumorsareportoffourcases AT ferroaa uncommonbreasttumorsareportoffourcases AT szlabis uncommonbreasttumorsareportoffourcases AT rosettid uncommonbreasttumorsareportoffourcases AT cremonezzidc uncommonbreasttumorsareportoffourcases AT taddeie tumoresinfrecuentesdelamamacomunicacionde4casos AT ferroaa tumoresinfrecuentesdelamamacomunicacionde4casos AT szlabis tumoresinfrecuentesdelamamacomunicacionde4casos AT rosettid tumoresinfrecuentesdelamamacomunicacionde4casos AT cremonezzidc tumoresinfrecuentesdelamamacomunicacionde4casos |
| first_indexed |
2024-09-03T21:04:13Z |
| last_indexed |
2024-09-03T21:04:13Z |
| _version_ |
1809210360586043392 |
| spelling |
I10-R327-article-391032024-04-15T16:14:45Z Uncommon breast tumors. A report of four cases Tumores infrecuentes de la mama. Comunicación de 4 casos Taddei, E Ferro, AA Szlabi, S Rosetti, D Cremonezzi, DC breast liposarcoma angiosarcoma myofibroblastoma adenomyoepithelioma MAMA liposarcoma angiosarcoma miofibroblastoma adenomioepitelioma Breast cancer is the most common malignancy and the second leading cause of cancer mortality in women, forcing the determination of an early and accurate diagnosis. There are also other uncommon neoplastic lesions. On account that many of them have different prognosis and treatment, it is important to differentiate them. The objective of this work is to interpret the morphology of 4 cases of exceptional presentation, in order to consider them in medical practice. Case 1: 30yo woman, tumor in right upper-outer quadrant. Biopsy: compatible with signet-ring cell carcinoma. In 6mo it grew considerably and a simple mastectomy was performed. We observed a whitish and ulcerated tumor of 24x22x8 cm. Microscopy: mesenchymal neoplasm, marked anisokaryosis, vacuolated cytoplasm, bizarre nuclei, increased mitoses, necrosis, and ulcerated skin. Triple-negative, Ki-67 30%. Diagnosis: Primary pleomorphic liposarcoma. Case 2: 63yo woman with a left painless multinodular mass. Simple mastectomy. Intraoperative biopsy: myxoid spindle cell lesion. Macroscopy: 25 cm tumor, lobulated and pseudoencapsulated. Cut surface is solid, grayish, with mucinous areas and necrohemorrhagic foci. Microscopy: spindle cells, clear cytoplasms, small, hyperchromatic nuclei, inconspicuous nucleoli, nuclear pseudoinclusions, myxoid background, collagenous areas, scarce mitoses. CD34(+), ASMA(+), Ki-67 15%. Diagnosis: Breast myofibroblastoma. Case 3: 82yo woman with a verruciform mass on the skin of the right breast. Macroscopy: 1.4x1x0.9 cm lesion, reddish brown, well-defined borders. At the surgical limit, another elevated lesion is observed, 1.3x9x0.5 cm, whitish, ulcerated. Microscopy: dermis with atypical neoplastic endothelial cells, forming dilated vessels and papillae, Others are spindle-shaped and epithelioid. Diagnosis: High grade angiosarcoma. Case 4: 42yo woman, right painless palpable mass. Quadrantectomy. Macroscopy: 0.6 cm multilobulated, irregular, whitish lesion with central cystification. Microscopy: lobular tubulo-epithelial structures surrounded by basal and interstitial myoepithelial cells with clear, polygonal, and fused cytoplasm. p63(+), Actin(+), Vimentin(+), low Ki-67. Diagnosis: lobulated adenomyoepithelioma Uncommon cases of neoplasms require specific morphological criteria and resolution with immunohistochemical techniques in most cases. Diagnoses must be confirmed with histopathological study and eventually with immunohytochemistry. El cáncer de mama es la neoplasia maligna más frecuente y la segunda causa de mortalidad por cáncer en mujeres, obligando a la determinación de un diagnóstico precoz y certero. Existen además otras lesiones neoplásicas infrecuentes. Debido a que muchas de ellas tienen distinto pronóstico y tratamiento, es importante diferenciarlas. El objetivo de este trabajo es interpretar la morfología de 4 casos de presentación excepcional, a fin de considerarlos en la práctica médica. Caso 1: Mujer de 30a, tumor en cuadrante supero-externo derecho. Biopsia: compatible con carcinoma en anillo de sello. En 6m creció considerablemente y se realizó mastectomía simple. Observamos un tumor blanquecino y ulcerado de 24x22x8 cm. Microscopía: neoplasia mesenquimal, marcada anisocariosis, citoplasmas vacuolados, núcleos bizarros, mitosis incrementadas, necrosis y piel ulcerada. Triple negativo, Ki67 30%. Diagnóstico: Liposarcoma pleomórfico primario. Caso 2: Mujer de 63a con masa multinodular indolora izquierda. Mastectomía simple. Biopsia intraoperatoria: lesión fusocelular mixoide. Macroscopía: tumor de 25 cm, lobulado y pseudoencapsulado. Al corte es sólido, grisáceo, áreas mucinosas y focos necrohemorrágicos. Microscopía: células fusiformes, citoplasmas claros, núcleos pequeños, hipercromáticos, nucléolos inconspicuos, pseudoinclusiones nucleares, fondo mixoide, áreas colágenas, mitosis escasas. CD34(+), ASMA(+), Ki-67 15%. Diagnóstico: Miofibroblastoma mamario. Caso 3: Mujer, 82a con masa verruciforme en piel de mama derecha. Macroscopía: lesión de 1,4x1x0,9 cm, pardo rojiza, bordes netos. En límite quirúrgico se observa otra lesión sobreelevada, de 1,3x9x0,5 cm, blanquecina, ulcerada. Microscopía: dermis con células neoplásicas endoteliales atípicas, fusadas y epitelioides, formando vasos dilatados y papilas. Diagnóstico: Angiosarcoma de alto grado. Caso 4: Mujer, 42a, masa palpable indolora derecha. Cuadrantectomía. Macroscopía: lesión multilobulada de 0,6 cm, irregular, blanquecina, quistificación central. Microscopía: estructuras lobulares túbulo-epiteliales rodeadas por células mioepiteliales basales e intersticiales; de citoplasmas claros, poligonales y fusados. P63(+), Actina(+), Vimentina(+), Ki-67 bajo. Diagnóstico: Adenomioepitelioma lobular. Los casos de neoplasias infrecuentes necesitan criterios morfológicos específicos y resolución con técnicas de inmunohistoquímica en la mayoría de los casos. Los diagnósticos deben confirmarse con el estudio histopatológico y eventualmente con inmunohitoquímica. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2022-10-26 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion texto https://revistas.unc.edu.ar/index.php/med/article/view/39103 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 79 No. Suplemento JIC XXIII (2022): Suplemento JIC XXIII Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 79 Núm. Suplemento JIC XXIII (2022): Suplemento JIC XXIII Revista da Faculdade de Ciências Médicas de Córdoba; v. 79 n. Suplemento JIC XXIII (2022): Suplemento JIC XXIII 1853-0605 0014-6722 http://creativecommons.org/licenses/by-nc/4.0 |