Carcinoma de mama: expresión inmunohistoquímica de receptor estrogénico, progesterona, HER 2- NEU y KI 67. Correlación histopatológica y molecular de valor pronostico
Breast cancer is the leading cause of cancer death among women from developed as well as developing countries. The histopathological examination of the tumors provides information, which helps predict the biological behavior of the tumor. The immunohistochemical techniques, in turn, were successful...
| Autores principales: | , , , |
|---|---|
| Formato: | Artículo revista |
| Publicado: |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2022
|
| Materias: | |
| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/39032 |
| Aporte de: |
| id |
I10-R327-article-39032 |
|---|---|
| record_format |
ojs |
| institution |
Universidad Nacional de Córdoba |
| institution_str |
I-10 |
| repository_str |
R-327 |
| container_title_str |
Revista de la Facultad de Ciencias Médicas de Córdoba |
| format |
Artículo revista |
| topic |
breast cancer histopathology immunohistochemistry cáncer de mama histopatología inmunohistoquímica |
| spellingShingle |
breast cancer histopathology immunohistochemistry cáncer de mama histopatología inmunohistoquímica Ferraris, F Fonseca, I Asis, G Spitale, L Carcinoma de mama: expresión inmunohistoquímica de receptor estrogénico, progesterona, HER 2- NEU y KI 67. Correlación histopatológica y molecular de valor pronostico |
| topic_facet |
breast cancer histopathology immunohistochemistry cáncer de mama histopatología inmunohistoquímica |
| author |
Ferraris, F Fonseca, I Asis, G Spitale, L |
| author_facet |
Ferraris, F Fonseca, I Asis, G Spitale, L |
| author_sort |
Ferraris, F |
| title |
Carcinoma de mama: expresión inmunohistoquímica de receptor estrogénico, progesterona, HER 2- NEU y KI 67. Correlación histopatológica y molecular de valor pronostico |
| title_short |
Carcinoma de mama: expresión inmunohistoquímica de receptor estrogénico, progesterona, HER 2- NEU y KI 67. Correlación histopatológica y molecular de valor pronostico |
| title_full |
Carcinoma de mama: expresión inmunohistoquímica de receptor estrogénico, progesterona, HER 2- NEU y KI 67. Correlación histopatológica y molecular de valor pronostico |
| title_fullStr |
Carcinoma de mama: expresión inmunohistoquímica de receptor estrogénico, progesterona, HER 2- NEU y KI 67. Correlación histopatológica y molecular de valor pronostico |
| title_full_unstemmed |
Carcinoma de mama: expresión inmunohistoquímica de receptor estrogénico, progesterona, HER 2- NEU y KI 67. Correlación histopatológica y molecular de valor pronostico |
| title_sort |
carcinoma de mama: expresión inmunohistoquímica de receptor estrogénico, progesterona, her 2- neu y ki 67. correlación histopatológica y molecular de valor pronostico |
| description |
Breast cancer is the leading cause of cancer death among women from developed as well as developing countries. The histopathological examination of the tumors provides information, which helps predict the biological behavior of the tumor. The immunohistochemical techniques, in turn, were successful at showing the tumor characteristics of prognostic value. Moreover, the above-mentioned techniques have provided arguments that set subclassifications of diagnostic and therapeutic significance, which allow the medical practice to offer a personalized therapy by better classifying the type of neoplasm. The aim of this work is to contribute to the knowledge of the histopathological and immunohistochemical aspects as well as the molecular changes of this disease, in order to optimize those aspects related to the therapeutic conduct and approach of a disease, which causes high morbimortality rates.
The research included a total of 61 female patients who had breast cancer, diagnosed by histopathology. Said female patients were treated at Hospital Universitario de Maternidad y Neonatología of the National University of Cordoba from 2013 to 2018.
The most common molecular subtypes were Luminal A and Luminal B, while Her2 and Triple negative were less common according to the sample. The ductal y lobulillar histopathological types were not found associated with any of the immunophenotypes. No conclusion could be reached in relation to the papillary, metaplasic and mixed histological subtypes due to the fact that each of them was represented by just one case. A significant relation was found between the immunophenotype and the nuclear grade or the grade of differentiation, since the well-differentiated injuries were only found related to the Luminal A immunophenotype, while the Luminal B, Her2 and Triple negative immunophenotypes were associated with little or moderately differentiated injuries.
Although the study sampled a small population compared to studies reported, which provide results obtained in the analysis of populations with over hundreds of cases, it could show an immunophenotypic and anatomopathological reality which is not different. On the contrary, it agrees with the findings in the large-scale studies which were performed in different parts of the world by important researchers groups. |
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2022 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/39032 |
| work_keys_str_mv |
AT ferrarisf carcinomademamaexpresioninmunohistoquimicadereceptorestrogenicoprogesteronaher2neuyki67correlacionhistopatologicaymoleculardevalorpronostico AT fonsecai carcinomademamaexpresioninmunohistoquimicadereceptorestrogenicoprogesteronaher2neuyki67correlacionhistopatologicaymoleculardevalorpronostico AT asisg carcinomademamaexpresioninmunohistoquimicadereceptorestrogenicoprogesteronaher2neuyki67correlacionhistopatologicaymoleculardevalorpronostico AT spitalel carcinomademamaexpresioninmunohistoquimicadereceptorestrogenicoprogesteronaher2neuyki67correlacionhistopatologicaymoleculardevalorpronostico |
| first_indexed |
2024-09-03T21:04:00Z |
| last_indexed |
2024-09-03T21:04:00Z |
| _version_ |
1809210346605379584 |
| spelling |
I10-R327-article-390322024-04-15T16:14:45Z Carcinoma de mama: expresión inmunohistoquímica de receptor estrogénico, progesterona, HER 2- NEU y KI 67. Correlación histopatológica y molecular de valor pronostico Ferraris, F Fonseca, I Asis, G Spitale, L breast cancer histopathology immunohistochemistry cáncer de mama histopatología inmunohistoquímica Breast cancer is the leading cause of cancer death among women from developed as well as developing countries. The histopathological examination of the tumors provides information, which helps predict the biological behavior of the tumor. The immunohistochemical techniques, in turn, were successful at showing the tumor characteristics of prognostic value. Moreover, the above-mentioned techniques have provided arguments that set subclassifications of diagnostic and therapeutic significance, which allow the medical practice to offer a personalized therapy by better classifying the type of neoplasm. The aim of this work is to contribute to the knowledge of the histopathological and immunohistochemical aspects as well as the molecular changes of this disease, in order to optimize those aspects related to the therapeutic conduct and approach of a disease, which causes high morbimortality rates. The research included a total of 61 female patients who had breast cancer, diagnosed by histopathology. Said female patients were treated at Hospital Universitario de Maternidad y Neonatología of the National University of Cordoba from 2013 to 2018. The most common molecular subtypes were Luminal A and Luminal B, while Her2 and Triple negative were less common according to the sample. The ductal y lobulillar histopathological types were not found associated with any of the immunophenotypes. No conclusion could be reached in relation to the papillary, metaplasic and mixed histological subtypes due to the fact that each of them was represented by just one case. A significant relation was found between the immunophenotype and the nuclear grade or the grade of differentiation, since the well-differentiated injuries were only found related to the Luminal A immunophenotype, while the Luminal B, Her2 and Triple negative immunophenotypes were associated with little or moderately differentiated injuries. Although the study sampled a small population compared to studies reported, which provide results obtained in the analysis of populations with over hundreds of cases, it could show an immunophenotypic and anatomopathological reality which is not different. On the contrary, it agrees with the findings in the large-scale studies which were performed in different parts of the world by important researchers groups. El cáncer de mama es la principal causa de muerte por cáncer en mujeres de países desarrollados y en vías de desarrollo. El estudio histopatológico de los tumores proporciona información que permite predecir el comportamiento biológico del tumor. Las técnicas inmunohistoquímicas, a su vez, han logrado develar caracteres tumorales de valor pronóstico y proporcionado argumentos para establecer subclasificaciones de importancia diagnóstica y terapéutica, que acercan a la práctica médica la posibilidad de una terapia personalizada, al catalogar mejor el tipo de neoplasia. El objetivo del trabajo es contribuir al conocimiento de los aspectos histopatológicos, inmunohistoquímicos y cambios moleculares de esta afección, a fin de optimizar aspectos inherentes al abordaje y conducta terapéutica de una patología que produce una importante morbimortalidad. El estudio realizado, incluyó un total de 61 pacientes de género femenino con carcinoma de mama, diagnosticado por histopatología, que fueron asistidas en el Hospital Universitario de Maternidad y Neonatología de la Universidad Nacional de Córdoba durante el período 2013-2018. Los subtipos moleculares más frecuentes fueron el Luminal A y Luminal B, mientras que Her2 y Triple negativo fueron menos frecuentes en la muestra. Los tipos histológicos ductal y lobulillar no se encontraron asociados con alguno de los inmunofenotipos. No se pudo concluir sobre los subtipos histológicos papilar, metaplásico y mixto, debido a que estuvieron representados por solo un caso cada uno. Se encontró asociación significativa entre el inmunofenotipo y el grado nuclear o de diferenciación, ya que las lesiones bien diferenciadas sólo aparecieron asociadas con el inmunofenotipo Luminal A mientras que los inmunofenotipos Luminal B, Her2 y Triple negativo estuvieron asociados solamente con lesiones poco y moderadamente diferenciadas. Este estudio, aunque haya contado con una población pequeña comparada con estudios reportados, los cuales comunican resultados a partir del análisis de poblaciones que superan los cientos de casos, ha podido reflejar una realidad inmunofenotípica y anatomopatológica que no discrepa, sino por el contrario, acompaña a lo encontrado en ellos, estudios a gran escala, realizados en diferentes partes del mundo, por grandes equipos de investigadores. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2022-10-26 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion texto texto texto https://revistas.unc.edu.ar/index.php/med/article/view/39032 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 79 No. Suplemento JIC XXIII (2022): Suplemento JIC XXIII Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 79 Núm. Suplemento JIC XXIII (2022): Suplemento JIC XXIII Revista da Faculdade de Ciências Médicas de Córdoba; v. 79 n. Suplemento JIC XXIII (2022): Suplemento JIC XXIII 1853-0605 0014-6722 http://creativecommons.org/licenses/by-nc/4.0 |