Hydrops and intrauterine fetal death associated with parvovirus B19 infection. case report

Human parvovirus B19/B19V infection in pregnant women can be transmitted to the fetus and cause anemia, hydrops and fetal death in situations that are still poorly understood. Its clinical suspicion is important to request opportune studies in the mother and the fetus that can confirm the diagn...

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Autores principales: Dicuatro, N, Pedranti, M, Colazo Salbetti, MB, Boggio, GA, Ortiz, E, Folla Fuenzalida , M, Melideo, C, Lucchini, HD, Adamo , MP, Moreno, LB
Formato: Artículo revista
Publicado: Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2022
Materias:
hydrops fetal
parvovirus b19
intrauterine fetal death
hidropesía fetal
muerte fetal intrauterina.
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/39011
Aporte de:
Revista de la Facultad de Ciencias Médicas de Córdoba de Universidad Nacional de Córdoba
id I10-R327-article-39011
record_format ojs
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-327
container_title_str Revista de la Facultad de Ciencias Médicas de Córdoba
format Artículo revista
topic hydrops fetal
parvovirus b19
intrauterine fetal death
hidropesía fetal
parvovirus b19
muerte fetal intrauterina.
spellingShingle hydrops fetal
parvovirus b19
intrauterine fetal death
hidropesía fetal
parvovirus b19
muerte fetal intrauterina.
Dicuatro, N
Pedranti, M
Colazo Salbetti, MB
Boggio, GA
Ortiz, E
Folla Fuenzalida , M
Melideo, C
Lucchini, HD
Adamo , MP
Moreno, LB
Hydrops and intrauterine fetal death associated with parvovirus B19 infection. case report
topic_facet hydrops fetal
parvovirus b19
intrauterine fetal death
hidropesía fetal
parvovirus b19
muerte fetal intrauterina.
author Dicuatro, N
Pedranti, M
Colazo Salbetti, MB
Boggio, GA
Ortiz, E
Folla Fuenzalida , M
Melideo, C
Lucchini, HD
Adamo , MP
Moreno, LB
author_facet Dicuatro, N
Pedranti, M
Colazo Salbetti, MB
Boggio, GA
Ortiz, E
Folla Fuenzalida , M
Melideo, C
Lucchini, HD
Adamo , MP
Moreno, LB
author_sort Dicuatro, N
title Hydrops and intrauterine fetal death associated with parvovirus B19 infection. case report
title_short Hydrops and intrauterine fetal death associated with parvovirus B19 infection. case report
title_full Hydrops and intrauterine fetal death associated with parvovirus B19 infection. case report
title_fullStr Hydrops and intrauterine fetal death associated with parvovirus B19 infection. case report
title_full_unstemmed Hydrops and intrauterine fetal death associated with parvovirus B19 infection. case report
title_sort hydrops and intrauterine fetal death associated with parvovirus b19 infection. case report
description Human parvovirus B19/B19V infection in pregnant women can be transmitted to the fetus and cause anemia, hydrops and fetal death in situations that are still poorly understood. Its clinical suspicion is important to request opportune studies in the mother and the fetus that can confirm the diagnosis (specific antibodies and viral DNA). A fatal case of hydrops fetalis associated with B19V infection is reported. A 40-year-old patient with a controlled pregnancy (30 weeks of gestation). Consultation for not perceiving fetal movements. History of rheumatoid arthritis in remission (without treatment during pregnancy) and previous abortion (attributed to cytomegalovirus); receives alpha-methyldopa for pregnancy-induced hypertension with good evolution. Family history of systemic lupus erythematosus and scleroderma. She did not report rashes or previous parvoviral symptoms. Blood group 0 Rh+. Physical examination: blood pressure/BP 140-90mmHg, afebrile. Negative uterine dynamics (10 minutes), negative fetal heartbeat (doppler), closed cervix, intact amniotic membranes, negative genitorrhagia. Ultrasound: "single fetus died in utero, with pleural effusion, ascites and hydropic signs". A cesarean section was performed extracting a dead male fetus, with signs of maceration, weighing 1500g. Postoperative with good evolution. Discharge with analgesia and controls by obstetrics office, medical clinic and rheumatology. Pathological anatomy: "900g placenta, edematous chorionic villi, decreased villous capillaries with signs of moderate obliterative endarteritis; generalized edema attributable to hydrops." negative genetics. Maternal serum studies (2 months post-cesarean): indeterminate IgM-B19V=24.8IU/mL(cutoff/25), positive IgG-B19>50IU/mL(cutoff/3), positive PCR/B19V (limit detection) . Other negative TORCH results. IgM-CMV negative, IgG-CMV positive=709.5AU/mL(cutoff/6). In placenta: PCR/B19V negative. A case of hydrops with fetal death related to B19V is reported. The timely collection of samples could improve the efficiency of diagnostic methods and the interpretation of results in cases of such great impact on health.
publisher Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2022
url https://revistas.unc.edu.ar/index.php/med/article/view/39011
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spelling I10-R327-article-390112024-04-15T16:14:45Z Hydrops and intrauterine fetal death associated with parvovirus B19 infection. case report Hidropesía y muerte fetal intraútero asociada a infección por parvovirus B19. Reporte de un caso Dicuatro, N Pedranti, M Colazo Salbetti, MB Boggio, GA Ortiz, E Folla Fuenzalida , M Melideo, C Lucchini, HD Adamo , MP Moreno, LB hydrops fetal parvovirus b19 intrauterine fetal death hidropesía fetal parvovirus b19 muerte fetal intrauterina. Human parvovirus B19/B19V infection in pregnant women can be transmitted to the fetus and cause anemia, hydrops and fetal death in situations that are still poorly understood. Its clinical suspicion is important to request opportune studies in the mother and the fetus that can confirm the diagnosis (specific antibodies and viral DNA). A fatal case of hydrops fetalis associated with B19V infection is reported. A 40-year-old patient with a controlled pregnancy (30 weeks of gestation). Consultation for not perceiving fetal movements. History of rheumatoid arthritis in remission (without treatment during pregnancy) and previous abortion (attributed to cytomegalovirus); receives alpha-methyldopa for pregnancy-induced hypertension with good evolution. Family history of systemic lupus erythematosus and scleroderma. She did not report rashes or previous parvoviral symptoms. Blood group 0 Rh+. Physical examination: blood pressure/BP 140-90mmHg, afebrile. Negative uterine dynamics (10 minutes), negative fetal heartbeat (doppler), closed cervix, intact amniotic membranes, negative genitorrhagia. Ultrasound: "single fetus died in utero, with pleural effusion, ascites and hydropic signs". A cesarean section was performed extracting a dead male fetus, with signs of maceration, weighing 1500g. Postoperative with good evolution. Discharge with analgesia and controls by obstetrics office, medical clinic and rheumatology. Pathological anatomy: "900g placenta, edematous chorionic villi, decreased villous capillaries with signs of moderate obliterative endarteritis; generalized edema attributable to hydrops." negative genetics. Maternal serum studies (2 months post-cesarean): indeterminate IgM-B19V=24.8IU/mL(cutoff/25), positive IgG-B19>50IU/mL(cutoff/3), positive PCR/B19V (limit detection) . Other negative TORCH results. IgM-CMV negative, IgG-CMV positive=709.5AU/mL(cutoff/6). In placenta: PCR/B19V negative. A case of hydrops with fetal death related to B19V is reported. The timely collection of samples could improve the efficiency of diagnostic methods and the interpretation of results in cases of such great impact on health. La infección por parvovirus humano B19/B19V en la embarazada puede transmitirse al feto y provocar anemia, hidropesía y muerte fetal en situaciones aún poco conocidas. Su sospecha clínica es importante para solicitar estudios oportunos en la madre y el feto que puedan confirmar el diagnóstico (anticuerpos específicos y ADN viral). Se reporta un caso fatal de hidropesía fetal asociado a infección por B19V.  Paciente de 40 años con embarazo controlado (30 semanas de gestación). Consulta por no percibir movimientos fetales. Antecedente de artritis reumatoidea en remisión (sin tratamiento durante el embarazo) y aborto previo (atribuido a citomegalovirus); recibe alfa-metildopa por hipertensión-inducida-embarazo con buena evolución. Antecedentes familiares de lupus eritematoso sistémico y esclerodermia. No refiere exantemas o sintomatología parvoviral previa. Grupo sanguíneo 0 Rh+. Examen físico: tensión arterial/TA 140-90mmHg, afebril. Dinámica uterina negativa (10 minutos), latidos cardiacos fetales negativos (doppler), cérvix cerrado, membranas amnióticas íntegras, genitorragia negativa. Ecografía: "feto único muerto in útero, con derrame pleural, ascitis y signos hidrópicos”. Se realiza operación cesárea extrayendo feto masculino muerto, con signos de maceración, peso 1500g. Postoperatorio con buena evolución. Alta con analgesia y controles por consultorio de obstetricia, clínica médica y reumatología. Anatomía patológica: "placenta de 900g, vellosidades coriales edematosas, disminución de capilares vellosos con signos de endarteritis obliterativa moderada; edema generalizado atribuible a hidropesía". Genética negativa. Estudios en suero materno (2 meses post-cesárea): IgM-B19V indeterminado=24,8UI/mL(cutoff/25), IgG-B19 positiva>50UI/mL(cutoff/3), PCR/B19V positiva (límite detección). Resto de resultados TORCH negativos. IgM-CMV negativa, IgG-CMV positiva=709,5UA/mL(cutoff/6). En placenta: PCR/B19V negativa.  Se reporta un caso de hidropesía con muerte fetal relacionada a B19V. La obtención oportuna de muestras podría mejorar la eficiencia de los métodos diagnósticos y la interpretación de resultados en casos de tanto impacto para la salud.   Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2022-10-26 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion texto https://revistas.unc.edu.ar/index.php/med/article/view/39011 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 79 No. Suplemento JIC XXIII (2022): Suplemento JIC XXIII Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 79 Núm. Suplemento JIC XXIII (2022): Suplemento JIC XXIII Revista da Faculdade de Ciências Médicas de Córdoba; v. 79 n. Suplemento JIC XXIII (2022): Suplemento JIC XXIII 1853-0605 0014-6722 http://creativecommons.org/licenses/by-nc/4.0

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