Analgesic effectiveness of Clonidine vs Fentanyl as adjuvants in intrathecal anesthesia of lower abdomen and trauma surgeries
Clonidine, which has been used for more than 15 years in humans, was initially used as an antihypertensive, resuming its usefulness in epidural regional anesthesia since the end of 1996 and is currently part of the anesthesiologist's therapeutic armamentarium due to its analgesic properties and...
Guardado en:
| Autores principales: | , |
|---|---|
| Formato: | Artículo revista |
| Publicado: |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2022
|
| Materias: | |
| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/38968 |
| Aporte de: |
| id |
I10-R327-article-38968 |
|---|---|
| record_format |
ojs |
| institution |
Universidad Nacional de Córdoba |
| institution_str |
I-10 |
| repository_str |
R-327 |
| container_title_str |
Revista de la Facultad de Ciencias Médicas de Córdoba |
| format |
Artículo revista |
| topic |
clonidine bupivacaine hyperbaric intrathecal analgesia bupivacaina clonidina hiperbarica intratecal analgesia |
| spellingShingle |
clonidine bupivacaine hyperbaric intrathecal analgesia bupivacaina clonidina hiperbarica intratecal analgesia Gareis, L Santiago, RG Analgesic effectiveness of Clonidine vs Fentanyl as adjuvants in intrathecal anesthesia of lower abdomen and trauma surgeries |
| topic_facet |
clonidine bupivacaine hyperbaric intrathecal analgesia bupivacaina clonidina hiperbarica intratecal analgesia |
| author |
Gareis, L Santiago, RG |
| author_facet |
Gareis, L Santiago, RG |
| author_sort |
Gareis, L |
| title |
Analgesic effectiveness of Clonidine vs Fentanyl as adjuvants in intrathecal anesthesia of lower abdomen and trauma surgeries |
| title_short |
Analgesic effectiveness of Clonidine vs Fentanyl as adjuvants in intrathecal anesthesia of lower abdomen and trauma surgeries |
| title_full |
Analgesic effectiveness of Clonidine vs Fentanyl as adjuvants in intrathecal anesthesia of lower abdomen and trauma surgeries |
| title_fullStr |
Analgesic effectiveness of Clonidine vs Fentanyl as adjuvants in intrathecal anesthesia of lower abdomen and trauma surgeries |
| title_full_unstemmed |
Analgesic effectiveness of Clonidine vs Fentanyl as adjuvants in intrathecal anesthesia of lower abdomen and trauma surgeries |
| title_sort |
analgesic effectiveness of clonidine vs fentanyl as adjuvants in intrathecal anesthesia of lower abdomen and trauma surgeries |
| description |
Clonidine, which has been used for more than 15 years in humans, was initially used as an antihypertensive, resuming its usefulness in epidural regional anesthesia since the end of 1996 and is currently part of the anesthesiologist's therapeutic armamentarium due to its analgesic properties and sedatives, offering their maximum benefit in pain control in the intraoperative and postoperative period. Clonidine in combination with opiate drugs and local anesthetics improves the quality of analgesia and reduces the dose of these drugs by up to 50%. The use of intrathecal clonidine as an adjuvant in spinal anesthesia would improve the anesthetic and analgesic quality in relation to the use of fentanyl as an adjuvant, in patients undergoing lower abdominal and lower limb trauma surgeries. Objective: To determine the analgesic and anesthetic effectiveness of clonidine vs. Fentanyl as adjuvants for intrathecal anesthesia
A randomized, prospective, double-blind clinical study was conducted at Hospital Misericordia approved by CIEIS. Total 60 (sixty) patients undergoing lower abdominal and lower limb trauma surgeries with spinal anesthesia, divided into two groups. Group C (n=30) Hyperbaric bupivacaine 0.5% 15 mg of + 1 mcg/kg of clonidine; Group F (n=30) Hyperbaric bupivacaine 0.5% 15 mg of hyperbaric bupivacaine 0.5% + 10 mcg of fentanyl. The guidelines of the Declaration of Helsinki were followed.
Statistically significant differences (p = 0.0001) were observed in the time that elapses between the intrathecal administration of the drugs and the request for the first dose of additional analgesia. Fentanyl 2 hours ± 2.1 compared to clonidine 6 hours ± 2.91. Statistically significant differences are also observed (p = 0.001), with a LEB at the time of requesting the first dose higher for Fentanyl of 4-6 in relation to Clonidine with 1-3.
The bupivacaine-clonidine analgesic scheme prolongs the sensory blockade, managing to reduce intraoperative and postoperative pain, reaching EVN values (verbal numerical scale) 0 at the end of surgery and motor blockade, reducing the need for rescue analgesia. with morphine; all this in a significant way compared to fentanyl. |
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2022 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/38968 |
| work_keys_str_mv |
AT gareisl analgesiceffectivenessofclonidinevsfentanylasadjuvantsinintrathecalanesthesiaoflowerabdomenandtraumasurgeries AT santiagorg analgesiceffectivenessofclonidinevsfentanylasadjuvantsinintrathecalanesthesiaoflowerabdomenandtraumasurgeries AT gareisl efectividadanalgesicadeclonidinavsfentanilocomoadyuvantesenanestesiaintratecaldecirugiasabdomeninferiorytraumatologica AT santiagorg efectividadanalgesicadeclonidinavsfentanilocomoadyuvantesenanestesiaintratecaldecirugiasabdomeninferiorytraumatologica |
| first_indexed |
2024-09-03T21:03:49Z |
| last_indexed |
2024-09-03T21:03:49Z |
| _version_ |
1809210335465308160 |
| spelling |
I10-R327-article-389682024-04-15T16:14:45Z Analgesic effectiveness of Clonidine vs Fentanyl as adjuvants in intrathecal anesthesia of lower abdomen and trauma surgeries Efectividad analgésica de Clonidina vs Fentanilo como adyuvantes en anestesia intratecal de cirugías abdomen inferior y traumatológica Gareis, L Santiago, RG clonidine bupivacaine hyperbaric intrathecal analgesia bupivacaina clonidina hiperbarica intratecal analgesia Clonidine, which has been used for more than 15 years in humans, was initially used as an antihypertensive, resuming its usefulness in epidural regional anesthesia since the end of 1996 and is currently part of the anesthesiologist's therapeutic armamentarium due to its analgesic properties and sedatives, offering their maximum benefit in pain control in the intraoperative and postoperative period. Clonidine in combination with opiate drugs and local anesthetics improves the quality of analgesia and reduces the dose of these drugs by up to 50%. The use of intrathecal clonidine as an adjuvant in spinal anesthesia would improve the anesthetic and analgesic quality in relation to the use of fentanyl as an adjuvant, in patients undergoing lower abdominal and lower limb trauma surgeries. Objective: To determine the analgesic and anesthetic effectiveness of clonidine vs. Fentanyl as adjuvants for intrathecal anesthesia A randomized, prospective, double-blind clinical study was conducted at Hospital Misericordia approved by CIEIS. Total 60 (sixty) patients undergoing lower abdominal and lower limb trauma surgeries with spinal anesthesia, divided into two groups. Group C (n=30) Hyperbaric bupivacaine 0.5% 15 mg of + 1 mcg/kg of clonidine; Group F (n=30) Hyperbaric bupivacaine 0.5% 15 mg of hyperbaric bupivacaine 0.5% + 10 mcg of fentanyl. The guidelines of the Declaration of Helsinki were followed. Statistically significant differences (p = 0.0001) were observed in the time that elapses between the intrathecal administration of the drugs and the request for the first dose of additional analgesia. Fentanyl 2 hours ± 2.1 compared to clonidine 6 hours ± 2.91. Statistically significant differences are also observed (p = 0.001), with a LEB at the time of requesting the first dose higher for Fentanyl of 4-6 in relation to Clonidine with 1-3. The bupivacaine-clonidine analgesic scheme prolongs the sensory blockade, managing to reduce intraoperative and postoperative pain, reaching EVN values (verbal numerical scale) 0 at the end of surgery and motor blockade, reducing the need for rescue analgesia. with morphine; all this in a significant way compared to fentanyl. La clonidina la cual ha sido utilizada por más de 15 años en humanos, inicialmente se usó como antihipertensivo, retomándose su utilidad en anestesia regional por vía epidural desde finales de 1996 y actualmente forma parte del armamentario terapéutico del anestesiólogo por sus propiedades analgésicas y sedantes, ofreciendo su máximo beneficio en el control del dolor en el periodo intraoperatorio y posoperatorio. Clonidina en combinación con fármacos opiáceos y anestésicos locales, mejora la calidad de la analgesia y disminuye la dosis de estos fármacos hasta un 50%. El uso de clonidina intratecal como adyuvante en anestesia raquídea mejoraria la calidad anestésica y analgésica en relación al uso de fentanilo como adyuvante, en pacientes sometidos a cirugías de abdomen inferior y traumatológicas de miembro inferior. Objetivo: Determinar la efectividad analgésica y anestésica de clonidina vs. fentanilo como coadyuvantes de la anestesia intratecal Se realizó un estudio clínico aleatorio randomizado, prospectivo, doble ciego en Hospital Misericordia aprobado por CIEIS. Total 60 (sesenta) pacientes sometidos a cirugías de abdomen inferior y traumatológicas de miembro inferior con anestesia raquídea, distribuidos en dos grupos. Grupo C (n=30) Bupivacaina hiperbárica 0.5% 15 mg de + 1 mcg/kg de clonidina; Grupo F (n=30) Bupivacaina hiperbárica 0.5% 15 mg de bupivacaina hiperbárica 0.5% + 10 mcg de fentanilo. Se siguieron los lineamientos de la declaración de Helsinki. Se apreciaron diferencias estadísticamente significativas (p = 0,0001) en el tiempo que transcurre entre la administración intratecal de los medicamentos hasta la solicitud de la primera dosis de analgesia adicional. Fentanilo 2 horas ± 2,1 en comparación con clonidina 6 horas ± 2,91. Se aprecian también diferencias estadísticamente significativas (p = 0,001), con una EVN en el momento de la solicitud de la primera dosis superior para Fentanilo de 4-6 en relación a la Clonidina con 1-3. El esquema analgésico Bupivacaina-Clonidina prolonga el bloqueo sensitivo, logrando disminuir el dolor en el intraoperatorio y postoperatorio, alcanzando valores EVN (escala verbal numerica) 0 al termino de la cirugía y del bloqueo motor, reduciendo la necesidad de realizar analgesia de rescate con morfina; todo ello en forma significativa comparada a fentanilo. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2022-10-26 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion texto https://revistas.unc.edu.ar/index.php/med/article/view/38968 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 79 No. Suplemento JIC XXIII (2022): Suplemento JIC XXIII Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 79 Núm. Suplemento JIC XXIII (2022): Suplemento JIC XXIII Revista da Faculdade de Ciências Médicas de Córdoba; v. 79 n. Suplemento JIC XXIII (2022): Suplemento JIC XXIII 1853-0605 0014-6722 http://creativecommons.org/licenses/by-nc/4.0 |