Therapeutic alternatives for drug-associated maxillary osteonecrosis (MRONJ): reports of two clinical cases and review of the literature.: reportes de dos casos clínicos y revisión de la literatura
Introduction: Drug-associated Maxillary Osteonecrosis is one of the most relevant adverse effects in treatment with antiresorptive drugs such as bisphosphonates and denosumab. Oncological conditions such as multiple myeloma, breast cancer, prostate, and bone-metabolic disorders such as osteoporosis...
| Autores principales: | , , , |
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| Formato: | Artículo revista |
| Lenguaje: | Español |
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2022
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/37289 |
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I10-R327-article-37289 |
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ojs |
| institution |
Universidad Nacional de Córdoba |
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I-10 |
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R-327 |
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Revista de la Facultad de Ciencias Médicas de Córdoba |
| language |
Español |
| format |
Artículo revista |
| topic |
bisphosphonate induced osteonecrosis of the jaws therapeutics platelet-rich fibrin osteonecrosis de los maxilares asociada a bifosfonatos tratamientos fibrina rica en plaquetas osteonecrose da arcada osseodentária associada a difosfonatos terapêutica fibrina rica em plaquetas |
| spellingShingle |
bisphosphonate induced osteonecrosis of the jaws therapeutics platelet-rich fibrin osteonecrosis de los maxilares asociada a bifosfonatos tratamientos fibrina rica en plaquetas osteonecrose da arcada osseodentária associada a difosfonatos terapêutica fibrina rica em plaquetas Leonardi, Nicolás Gilligan , Gerardo Piemonte, Eduardo Panico, René Therapeutic alternatives for drug-associated maxillary osteonecrosis (MRONJ): reports of two clinical cases and review of the literature.: reportes de dos casos clínicos y revisión de la literatura |
| topic_facet |
bisphosphonate induced osteonecrosis of the jaws therapeutics platelet-rich fibrin osteonecrosis de los maxilares asociada a bifosfonatos tratamientos fibrina rica en plaquetas osteonecrose da arcada osseodentária associada a difosfonatos terapêutica fibrina rica em plaquetas |
| author |
Leonardi, Nicolás Gilligan , Gerardo Piemonte, Eduardo Panico, René |
| author_facet |
Leonardi, Nicolás Gilligan , Gerardo Piemonte, Eduardo Panico, René |
| author_sort |
Leonardi, Nicolás |
| title |
Therapeutic alternatives for drug-associated maxillary osteonecrosis (MRONJ): reports of two clinical cases and review of the literature.: reportes de dos casos clínicos y revisión de la literatura |
| title_short |
Therapeutic alternatives for drug-associated maxillary osteonecrosis (MRONJ): reports of two clinical cases and review of the literature.: reportes de dos casos clínicos y revisión de la literatura |
| title_full |
Therapeutic alternatives for drug-associated maxillary osteonecrosis (MRONJ): reports of two clinical cases and review of the literature.: reportes de dos casos clínicos y revisión de la literatura |
| title_fullStr |
Therapeutic alternatives for drug-associated maxillary osteonecrosis (MRONJ): reports of two clinical cases and review of the literature.: reportes de dos casos clínicos y revisión de la literatura |
| title_full_unstemmed |
Therapeutic alternatives for drug-associated maxillary osteonecrosis (MRONJ): reports of two clinical cases and review of the literature.: reportes de dos casos clínicos y revisión de la literatura |
| title_sort |
therapeutic alternatives for drug-associated maxillary osteonecrosis (mronj): reports of two clinical cases and review of the literature.: reportes de dos casos clínicos y revisión de la literatura |
| description |
Introduction: Drug-associated Maxillary Osteonecrosis is one of the most relevant adverse effects in treatment with antiresorptive drugs such as bisphosphonates and denosumab. Oncological conditions such as multiple myeloma, breast cancer, prostate, and bone-metabolic disorders such as osteoporosis lead the indications for these antiresorptive therapies. Treatment is complex because the disease is often refractory. Pharmacological, conservative and surgical treatments are described. Objective: The aim of this study is to report two clinical cases of MRONJ treated with two different therapeutic protocols and the analysis of the available literature on these aspects based on the clinical classification defined by the American Association of Oral and Maxillofacial Surgeons (AAOMS). Conclusion: Patients who develop clinical signs of great morbidity associated with MRONJ, may see their quality of life conditioned and suffer a worsening of their underlying pathology. MRONJ treatment is conditioned by the stage of the disease, its success depends on interdisciplinary management and strict medical and dental clinical follow-up, as well as rigorous monitoring to prevent or detect future recurrences early. |
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2022 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/37289 |
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I10-R327-article-372892023-03-20T16:24:58Z Therapeutic alternatives for drug-associated maxillary osteonecrosis (MRONJ): reports of two clinical cases and review of the literature.: reportes de dos casos clínicos y revisión de la literatura Alternativas terapéuticas de osteonecrosis maxilar asociada a medicamentos (ONMAM): reportes de dos casos clínicos y revisión de la literatura Alternativas terapêuticas de osteonecrose maxilar associada a medicamentos (ONMAM): relato de dois casos clínicos e revisão da literatura: reportes de dos casos clínicos y revisión de la literatura Leonardi, Nicolás Gilligan , Gerardo Piemonte, Eduardo Panico, René bisphosphonate induced osteonecrosis of the jaws therapeutics platelet-rich fibrin osteonecrosis de los maxilares asociada a bifosfonatos tratamientos fibrina rica en plaquetas osteonecrose da arcada osseodentária associada a difosfonatos terapêutica fibrina rica em plaquetas Introduction: Drug-associated Maxillary Osteonecrosis is one of the most relevant adverse effects in treatment with antiresorptive drugs such as bisphosphonates and denosumab. Oncological conditions such as multiple myeloma, breast cancer, prostate, and bone-metabolic disorders such as osteoporosis lead the indications for these antiresorptive therapies. Treatment is complex because the disease is often refractory. Pharmacological, conservative and surgical treatments are described. Objective: The aim of this study is to report two clinical cases of MRONJ treated with two different therapeutic protocols and the analysis of the available literature on these aspects based on the clinical classification defined by the American Association of Oral and Maxillofacial Surgeons (AAOMS). Conclusion: Patients who develop clinical signs of great morbidity associated with MRONJ, may see their quality of life conditioned and suffer a worsening of their underlying pathology. MRONJ treatment is conditioned by the stage of the disease, its success depends on interdisciplinary management and strict medical and dental clinical follow-up, as well as rigorous monitoring to prevent or detect future recurrences early. Introducción: La Osteonecrosis Maxilar asociada a Medicamentos (ONMAM) constituye uno de los efectos adversos más relevantes en el tratamiento con drogas antirresortivas como bifosfonatos y denosumab. Patologías oncológicas como mieloma múltiple, cáncer de mama, próstata, y alteraciones óseas-metabólicas como la osteoporosis lideran las indicaciones para estas terapias antirresortivas. El tratamiento es complejo debido a que muchas veces, la enfermedad es refractaria a la terapéutica aplicada. Se describen tratamientos farmacológicos, conservadores y quirúrgicos. Objetivo: El objetivo de este trabajo es reportar dos casos clínicos de ONMAM tratados con dos protocolos terapéuticos diferentes y el análisis de la literatura disponible en la actualidad sobre estos aspectos en base a la clasificación clínica definida por la American Association of Oral and Maxillofacial Surgeons (AAOMS). Conclusión: Los pacientes que desarrollan cuadros clínicos bucales de gran morbilidad como lo es ONMAM, pueden ver condicionada su calidad de vida y sufrir un agravamiento de su patología de base. El tratamiento de ONMAM está condicionado al estadio de la enfermedad, el éxito del mismo depende del manejo interdisciplinario y de un estricto seguimiento clínico médico y odontológico, así como también un riguroso monitoreo para evitar o detectar precozmente futuras recurrencias. Introdução: A Osteonecrose Maxilar Associada a Medicamentos (ONMAM) é um dos efeitos adversos mais relevantes no tratamento com drogas antirreabsortivas como bifosfonatos e denosumab. Patologias oncológicas como mieloma múltiplo, câncer de mama, próstata e distúrbios ósseo-metabólicos como osteoporose lideram as indicações para essas terapias antirreabsortivas. Nos últimos anos, a incidência de ONMAM foi mantida ou aumentada devido ao uso cada vez mais difundido dessas terapias. O tratamento é complexo porque a doença é muitas vezes refratária à terapia aplicada. Tratamentos farmacológicos, conservadores e cirúrgicos são descritos. Objetivo: O objetivo deste trabalho é relatar dois casos clínicos de OMNAM tratados com dois protocolos terapêuticos diferentes e a análise da literatura atualmente disponível sobre esses aspectos com base na classificação clínica definida pela American Association of Oral and Maxillofacial Surgeons (AAOMS). Conclusão: Pacientes que desenvolvem quadros clínicos bucais de grande morbidade, como o ONMAM, podem ter sua qualidade de vida condicionada e sofrer um agravamento de sua patologia de base. O tratamento do ONMAM é condicionado pelo estágio da doença, seu sucesso depende de manejo interdisciplinar e acompanhamento clínico médico e odontológico rigoroso, além de acompanhamento rigoroso para prevenir ou detectar precocemente futuras recidivas. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2022-12-21 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion text/html application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/37289 10.31053/1853.0605.v79.n4.37289 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 79 No. 4 (2022); 379-382 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 79 Núm. 4 (2022); 379-382 Revista da Faculdade de Ciências Médicas de Córdoba; v. 79 n. 4 (2022); 379-382 1853-0605 0014-6722 10.31053/1853.0605.v79.n4 spa https://revistas.unc.edu.ar/index.php/med/article/view/37289/39770 https://revistas.unc.edu.ar/index.php/med/article/view/37289/39902 Derechos de autor 2022 Universidad Nacional de Córdoba http://creativecommons.org/licenses/by-nc/4.0 |