Cushing's disease in pregnancy and treatment with cabergoline: obstetric and neonatal results

Introduction: Cushing's disease (CD) is rare during pregnancy and is associated with significant maternal and fetal complications. The aim was to report the case of a patient with CD who achieved pregnancy and delivery without complications after treatment with low doses of cabergoline. Methods...

Descripción completa

Detalles Bibliográficos
Autores principales: Murillo, Natacha Belén, Ramacciotti, Constanza Fernanda, Fux-Otta, Carolina, Cecenarro, Laura Anahi
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2023
Materias:
Cabergoline;
Cushing's syndrome;
pregnancy
cabergolina
síndrome de cushing;
embarazo
Cabergolina;
gravidez
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/37056
Aporte de:
Revista de la Facultad de Ciencias Médicas de Córdoba de Universidad Nacional de Córdoba
id I10-R327-article-37056
record_format ojs
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-327
container_title_str Revista de la Facultad de Ciencias Médicas de Córdoba
language Español
format Artículo revista
topic Cabergoline;
Cushing's syndrome;
pregnancy
cabergolina
síndrome de cushing;
embarazo
Cabergolina;
síndrome de cushing;
gravidez
spellingShingle Cabergoline;
Cushing's syndrome;
pregnancy
cabergolina
síndrome de cushing;
embarazo
Cabergolina;
síndrome de cushing;
gravidez
Murillo, Natacha Belén
Ramacciotti, Constanza Fernanda
Fux-Otta, Carolina
Cecenarro, Laura Anahi
Cushing's disease in pregnancy and treatment with cabergoline: obstetric and neonatal results
topic_facet Cabergoline;
Cushing's syndrome;
pregnancy
cabergolina
síndrome de cushing;
embarazo
Cabergolina;
síndrome de cushing;
gravidez
author Murillo, Natacha Belén
Ramacciotti, Constanza Fernanda
Fux-Otta, Carolina
Cecenarro, Laura Anahi
author_facet Murillo, Natacha Belén
Ramacciotti, Constanza Fernanda
Fux-Otta, Carolina
Cecenarro, Laura Anahi
author_sort Murillo, Natacha Belén
title Cushing's disease in pregnancy and treatment with cabergoline: obstetric and neonatal results
title_short Cushing's disease in pregnancy and treatment with cabergoline: obstetric and neonatal results
title_full Cushing's disease in pregnancy and treatment with cabergoline: obstetric and neonatal results
title_fullStr Cushing's disease in pregnancy and treatment with cabergoline: obstetric and neonatal results
title_full_unstemmed Cushing's disease in pregnancy and treatment with cabergoline: obstetric and neonatal results
title_sort cushing's disease in pregnancy and treatment with cabergoline: obstetric and neonatal results
description Introduction: Cushing's disease (CD) is rare during pregnancy and is associated with significant maternal and fetal complications. The aim was to report the case of a patient with CD who achieved pregnancy and delivery without complications after treatment with low doses of cabergoline. Methods: A 29-year-old woman diagnosed with CD (ACTH-secreting macroadenoma that produces displacement of the optic chiasm, infiltrates the right cavernous sinus and includes the internal carotid artery). She undergoes transsphenoidal surgery with incomplete tumor resection. After a year of clinical stability, the symptoms reappeared, so medical treatment with cabergoline was established. Results: At the first trimester, clinical and biochemical parameters indicate active CD, so it was decided to readminister Cabergoline at low doses for the rest of the pregnancy. The response to dopaminergic agonists was excellent, and the laboratories were normalized, and the disease was controlled. The patient delivered a healthy girl at 38-week-old, with normal percentiles and without complications. Conclusion: Pregnancy is rare in patients with CD. However, the consequences of maternal-fetal exposure to hypercortisolism can be serious. Our experience with the use of low-dose cabergoline in a pregnant woman with CD provides favourable data to the few existing bibliographic reports, adding evidence on the safety profile of the drug in this group of patients.
publisher Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2023
url https://revistas.unc.edu.ar/index.php/med/article/view/37056
work_keys_str_mv AT murillonatachabelen cushingsdiseaseinpregnancyandtreatmentwithcabergolineobstetricandneonatalresults
AT ramacciotticonstanzafernanda cushingsdiseaseinpregnancyandtreatmentwithcabergolineobstetricandneonatalresults
AT fuxottacarolina cushingsdiseaseinpregnancyandtreatmentwithcabergolineobstetricandneonatalresults
AT cecenarrolauraanahi cushingsdiseaseinpregnancyandtreatmentwithcabergolineobstetricandneonatalresults
AT murillonatachabelen enfermedaddecushingenelembarazoyusodecabergolinaresultadosobstetricosyneonatales
AT ramacciotticonstanzafernanda enfermedaddecushingenelembarazoyusodecabergolinaresultadosobstetricosyneonatales
AT fuxottacarolina enfermedaddecushingenelembarazoyusodecabergolinaresultadosobstetricosyneonatales
AT cecenarrolauraanahi enfermedaddecushingenelembarazoyusodecabergolinaresultadosobstetricosyneonatales
AT murillonatachabelen doencadecushingnagravidezetratamentocomcabergolinaresultadosobstetricoseneonatais
AT ramacciotticonstanzafernanda doencadecushingnagravidezetratamentocomcabergolinaresultadosobstetricoseneonatais
AT fuxottacarolina doencadecushingnagravidezetratamentocomcabergolinaresultadosobstetricoseneonatais
AT cecenarrolauraanahi doencadecushingnagravidezetratamentocomcabergolinaresultadosobstetricoseneonatais
first_indexed 2024-09-03T21:03:31Z
last_indexed 2024-09-03T21:03:31Z
_version_ 1809210316195627008
spelling I10-R327-article-370562023-07-10T12:03:20Z Cushing's disease in pregnancy and treatment with cabergoline: obstetric and neonatal results Enfermedad de Cushing en el embarazo y uso de cabergolina: resultados obstétricos y neonatales Doença de Cushing na gravidez e tratamento com cabergolina: resultados obstétricos e neonatais Murillo, Natacha Belén Ramacciotti, Constanza Fernanda Fux-Otta, Carolina Cecenarro, Laura Anahi Cabergoline; Cushing's syndrome; pregnancy cabergolina síndrome de cushing; embarazo Cabergolina; síndrome de cushing; gravidez Introduction: Cushing's disease (CD) is rare during pregnancy and is associated with significant maternal and fetal complications. The aim was to report the case of a patient with CD who achieved pregnancy and delivery without complications after treatment with low doses of cabergoline. Methods: A 29-year-old woman diagnosed with CD (ACTH-secreting macroadenoma that produces displacement of the optic chiasm, infiltrates the right cavernous sinus and includes the internal carotid artery). She undergoes transsphenoidal surgery with incomplete tumor resection. After a year of clinical stability, the symptoms reappeared, so medical treatment with cabergoline was established. Results: At the first trimester, clinical and biochemical parameters indicate active CD, so it was decided to readminister Cabergoline at low doses for the rest of the pregnancy. The response to dopaminergic agonists was excellent, and the laboratories were normalized, and the disease was controlled. The patient delivered a healthy girl at 38-week-old, with normal percentiles and without complications. Conclusion: Pregnancy is rare in patients with CD. However, the consequences of maternal-fetal exposure to hypercortisolism can be serious. Our experience with the use of low-dose cabergoline in a pregnant woman with CD provides favourable data to the few existing bibliographic reports, adding evidence on the safety profile of the drug in this group of patients. Introducción: La enfermedad de Cushing (EC) es rara durante el embarazo y se asocia con complicaciones maternas y fetales significativas. El objetivo fue reportar el caso de una paciente con EC que logró embarazo y parto sin complicaciones tras el tratamiento con dosis bajas de cabergolina. Métodos: Mujer de 29 años con diagnóstico de EC (macroadenoma secretor de ACTH que produce desplazamiento del quiasma óptico, infiltra el seno cavernoso derecho y engloba la arteria carótida interna). Se somete a cirugía transesfenoidal con resección tumoral incompleta. Luego de un año de estabilidad clínica, reaparecen los síntomas por lo que se instaura tratamiento médico con cabergolina. Durante el tratamiento la paciente concibe embarazo y se suspende la medicación. Resultados: En el primer trimestre, los parámetros clínicos y bioquímicos indican EC activa, por lo que se decide reinstaurar Cabergolina a dosis bajas durante el resto de la gestación. Con el agonista dopaminérgico se alcanza normalizar parámetros clínicos y de laboratorio y la paciente dio a luz una niña sana a las 38 semanas, dentro de percentiles normales y sin complicaciones. Conclusión: El embarazo es un evento raro en pacientes con EC. Sin embargo, las consecuencias de la exposición materno-fetal al hipercortisolismo pueden ser graves. Nuestra experiencia con el uso de cabergolina a dosis bajas en una embarazada con EC, aporta datos favorables a los escasos reportes bibliográficos existentes, sumando evidencia sobre el perfil de seguridad del fármaco en esta población de pacientes. Introdução: A doença de Cushing (DC) é rara durante a gravidez e está associada a complicações maternas e fetais significativas. O objetivo foi relatar o caso de uma paciente com DC que obteve gravidez e parto sem intercorrências após tratamento com baixas doses de cabergolina. Métodos: Mulher de 29 anos com diagnóstico de DC (macroadenoma secretor de ACTH que produz deslocamento do quiasma óptico, infiltra o seio cavernoso direito e engloba a artéria carótida interna). Foi submetido a cirurgia transesfenoidal com ressecção incompleta do tumor. Após um ano de estabilidade clínica, os sintomas reapareceram, sendo instituído tratamento clínico com cabergolina. Resultados: No primeiro trimestre, os parâmetros clínicos e bioquímicos indicaram DC ativa, então decidiu-se restabelecer a Cabergolina em baixas doses pelo resto da gravidez. Obteve-se excelente resposta ao agonista dopaminérgico com normalização laboratorial e a paciente deu à luz uma menina saudável de 38 semanas, dentro dos percentis normais e sem complicações. Conclusão: A gravidez é rara em pacientes com DC. No entanto, as consequências da exposição materno-fetal ao hipercortisolismo podem ser graves. Nossa experiência com o uso de cabergolina em baixa dose em gestante com DC fornece dados favoráveis aos poucos relatos bibliográficos existentes, acrescentando evidências sobre o perfil de segurança da droga nesse grupo de pacientes. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2023-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Texto text/html application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/37056 10.31053/1853.0605.v80.n1.37056 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 80 No. 1 (2023); 55-58 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 80 Núm. 1 (2023); 55-58 Revista da Faculdade de Ciências Médicas de Córdoba; v. 80 n. 1 (2023); 55-58 1853-0605 0014-6722 10.31053/1853.0605.v80.n1 spa https://revistas.unc.edu.ar/index.php/med/article/view/37056/41047 https://revistas.unc.edu.ar/index.php/med/article/view/37056/40951 Derechos de autor 2023 Universidad Nacional de Córdoba http://creativecommons.org/licenses/by-nc/4.0

Ejemplares similares