Células neuroendócrinas de la próstata
From the first description of Pretl in 1944, many authors have shown difterent morphological and immunohistochemical studies related to prostatic neuroendocrine cells. These cells belong to a neuroendocrine system, wide disseminated network, that is found in man)' human tissues. They secret neu...
Guardado en:
| Autores principales: | , , |
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| Formato: | Artículo revista |
| Lenguaje: | Español |
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2002
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| Materias: | |
| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/36848 |
| Aporte de: |
| Sumario: | From the first description of Pretl in 1944, many authors have shown difterent morphological and immunohistochemical studies related to prostatic neuroendocrine cells. These cells belong to a neuroendocrine system, wide disseminated network, that is found in man)' human tissues. They secret neuroendocrine peptides and play an important role in the glandular pithelium regulation (growing, differentiation, and exocrine secretion), in both normal and hyperplastic glands. They are also present in ordinary prostatic adenocarcinoma and in unusual small ccli carcinoma. Recently, it has been suggested that prostatic neuroendocrine celis may be relatedto prognosis in prostatic carcinoma, particulary in cases with hormonal therapy resistant. In this study, there are 23 prostatic disorders: 11 nodular hyperpiasias and 12 adenocarcinomas, and also arcas of normal gland.The objetive is the morphologic identification of these cells with sil ver impregnation technique, in normal tissuc, nodular hyperplasia and adenocarcinorna. In normal gland and nodular hyperpiasia, the NE cells can he seen along most of the gland or near the urcthra, solitary or in small clusters. These cells are located hetween acinar epithelium cells and basement membrane, but they are a]so found within the stroma in relationto nerve endings. They characteristically contain argyrophil and argentaffin granules in the cytoplasm and exhibit cytoplasmatic processes extended to acinar or urethral lumen. Within the stroma, they are seen isolated with dendritic or ribbon-like cytoplasmaticprocesses. In this study, there is only one adenocarcinoma of high grade with NE cells. In this neoplasm they are increase in number, and appear isolated and more polymorphic |
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