Circulation and clinical presentation of Metapneumovirus infection among pediatric inpatients with acute respiratory infection (ARI)
Abstract: Human Metapneumovirus (HMPV) was discovered in 2001. This virus is an important pathogen that causes ARI in children under 5 years old, for this reason many health-care centers are including its detection in the respiratory virus panel. Since the clinical presentation of ARI...
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| Formato: | Artículo revista |
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2021
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/35099 |
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I10-R327-article-35099 |
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ojs |
| institution |
Universidad Nacional de Córdoba |
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I-10 |
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R-327 |
| container_title_str |
Revista de la Facultad de Ciencias Médicas de Córdoba |
| format |
Artículo revista |
| topic |
Metapneumovirus inmunofluorescence bronchiolitis Metapneumovirus inmunofluorescencia bronquiolitis . |
| spellingShingle |
Metapneumovirus inmunofluorescence bronchiolitis Metapneumovirus inmunofluorescencia bronquiolitis . Garro, N Grutadauria, S Nader, V Kiener, A De Elías Boqué , R Circulation and clinical presentation of Metapneumovirus infection among pediatric inpatients with acute respiratory infection (ARI) |
| topic_facet |
Metapneumovirus inmunofluorescence bronchiolitis Metapneumovirus inmunofluorescencia bronquiolitis . |
| author |
Garro, N Grutadauria, S Nader, V Kiener, A De Elías Boqué , R |
| author_facet |
Garro, N Grutadauria, S Nader, V Kiener, A De Elías Boqué , R |
| author_sort |
Garro, N |
| title |
Circulation and clinical presentation of Metapneumovirus infection among pediatric inpatients with acute respiratory infection (ARI) |
| title_short |
Circulation and clinical presentation of Metapneumovirus infection among pediatric inpatients with acute respiratory infection (ARI) |
| title_full |
Circulation and clinical presentation of Metapneumovirus infection among pediatric inpatients with acute respiratory infection (ARI) |
| title_fullStr |
Circulation and clinical presentation of Metapneumovirus infection among pediatric inpatients with acute respiratory infection (ARI) |
| title_full_unstemmed |
Circulation and clinical presentation of Metapneumovirus infection among pediatric inpatients with acute respiratory infection (ARI) |
| title_sort |
circulation and clinical presentation of metapneumovirus infection among pediatric inpatients with acute respiratory infection (ari) |
| description |
Abstract:
Human Metapneumovirus (HMPV) was discovered in 2001. This virus is an important pathogen that causes ARI in children under 5 years old, for this reason many health-care centers are including its detection in the respiratory virus panel. Since the clinical presentation of ARI is common for all of the respiratory viruses, the participation of the virology laboratory becomes crucial to establish the etiologic diagnosis.
The objective of this study was to assess the circulation of HMPV and describe the clinical and epidemiological characteristics of the infection in a cohort of inpatients admitted at the pediatric ward of Sanatorio Allende (Córdoba, Argentina).
A descriptive analysis, previously approved by the Institution´s Ethical Committee, was conducted. 1311 consecutive respiratory samples, routinely taken from inpatients under 5 years old with diagnosis of ARI from May 2017 through December 2019, were included. Samples were tested by direct immunofluorescence for respiratory syncytial virus, influenza, parainfluenza, adenovirus and HMPV. Specimens were taken from day 1 to 7 (median 4), from the beginning of symptoms.
Out of the 1311 respiratory samples, 634 (48.4%) were positive for any of the assayed agents. HMPV was found in 53/634 samples (8.4%), with an increased incidence towards the end of winter and during spring. The median age was 10 months (range: 0-60 months), and 47% were girls. Forty-nine per cent (26/53) were admitted to the pediatric intensive care unit. The main signs and symptoms were: lower airway sounds (rhonchi and crackles 82%; stridor 43%), fever ≥38ºC (70%) and coughing (59%). Radiological findings at the admission were: interstitial infiltrate (22%), parahilar infiltrate (22%) and parenchymatous condensation (14%). The median of hospitalization days was 5 (2-18) and 86% of patients required oxygen therapy. At discharge, 55% of children were diagnosed as bronchiolitis.
The circulation of HMPV was proved in the studied population, justifying the detection of this viral pathogen, otherwise those inpatients would have remained without an etiological diagnosis. An opportune diagnosis directly impacts in improving the patient management and prevents the unnecessary use of antibiotics.
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| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2021 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/35099 |
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I10-R327-article-350992024-04-15T16:19:09Z Circulation and clinical presentation of Metapneumovirus infection among pediatric inpatients with acute respiratory infection (ARI) Circulación y presentación clínica de Metapneumovirus en pacientes pediátricos internados por infección respiratoria aguda (IRA) A Garro, N Grutadauria, S Nader, V Kiener, A De Elías Boqué , R Metapneumovirus inmunofluorescence bronchiolitis Metapneumovirus inmunofluorescencia bronquiolitis . Abstract: Human Metapneumovirus (HMPV) was discovered in 2001. This virus is an important pathogen that causes ARI in children under 5 years old, for this reason many health-care centers are including its detection in the respiratory virus panel. Since the clinical presentation of ARI is common for all of the respiratory viruses, the participation of the virology laboratory becomes crucial to establish the etiologic diagnosis. The objective of this study was to assess the circulation of HMPV and describe the clinical and epidemiological characteristics of the infection in a cohort of inpatients admitted at the pediatric ward of Sanatorio Allende (Córdoba, Argentina). A descriptive analysis, previously approved by the Institution´s Ethical Committee, was conducted. 1311 consecutive respiratory samples, routinely taken from inpatients under 5 years old with diagnosis of ARI from May 2017 through December 2019, were included. Samples were tested by direct immunofluorescence for respiratory syncytial virus, influenza, parainfluenza, adenovirus and HMPV. Specimens were taken from day 1 to 7 (median 4), from the beginning of symptoms. Out of the 1311 respiratory samples, 634 (48.4%) were positive for any of the assayed agents. HMPV was found in 53/634 samples (8.4%), with an increased incidence towards the end of winter and during spring. The median age was 10 months (range: 0-60 months), and 47% were girls. Forty-nine per cent (26/53) were admitted to the pediatric intensive care unit. The main signs and symptoms were: lower airway sounds (rhonchi and crackles 82%; stridor 43%), fever ≥38ºC (70%) and coughing (59%). Radiological findings at the admission were: interstitial infiltrate (22%), parahilar infiltrate (22%) and parenchymatous condensation (14%). The median of hospitalization days was 5 (2-18) and 86% of patients required oxygen therapy. At discharge, 55% of children were diagnosed as bronchiolitis. The circulation of HMPV was proved in the studied population, justifying the detection of this viral pathogen, otherwise those inpatients would have remained without an etiological diagnosis. An opportune diagnosis directly impacts in improving the patient management and prevents the unnecessary use of antibiotics. Resumen: El Metapneumovirus humano (MPVh) fue descubierto en 2001. Es un importante agente causal de IRA en menores de 5 años, por esta razón muchos centros de salud ya incluyen su detección en el panel de virosis respiratorias. Debido a que la presentación clínica de IRA es común para todos los virus respiratorios, la participación del laboratorio virológico es fundamental para establecer el diagnóstico etiológico. El objetivo de este trabajo fue establecer la circulación de MPVh y describir las características clínico-epidemiológicas de la infección en una población de niños atendidos en el Sanatorio Allende de Córdoba. Se realizó un análisis descriptivo, que fue aprobado por el Comité de Ética de la Institución. Se estudiaron consecutivamente 1311 muestras respiratorias, tomadas en forma rutinaria a pacientes menores de 5 años internados por IRA entre mayo de 2017- diciembre de 2019. Se analizó por inmunofluorescencia directa la presencia de: virus respiratorio sincicial, influenza, parainfluenza, adenovirus y MPVh. Las muestras fueron tomadas entre 1 y 7 días (mediana 4) de iniciados los síntomas. De las 1311 muestras respiratorias, 634 (48.4%) fueron positivas para alguno de los agentes estudiados. MPVh se encontró en 53/634 muestras (8,4%). Se observó un aumento de casos hacia finales del invierno y durante la primavera. La mediana de edad fue de 10 meses (rango: 0-60 meses), correspondiendo 47% al sexo femenino. El 49% de los pacientes (26/53) se internaron en UTI pediátrica a su ingreso. Los principales signos y síntomas observados fueron ruidos respiratorios bajos (roncus y crépitos 82%; sibilancias 43%), fiebre≥38ºC (70%) y tos (59%). Los hallazgos radiológicos de ingreso fueron: infiltrado intersticial (22%), infiltrado parahiliar (22%) y condensación parenquimatosa (14%). La mediana de días de hospitalización fue de 5 (2-18), requiriéndose oxigenoterapia en el 86% de los pacientes. El principal diagnóstico de egreso fue bronquiolitis (55%). Se comprobó la circulación de MPVh en la población estudiada, justificando la detección del agente viral, ya que de no hacerlo, los pacientes hospitalizados hubieran quedado sin diagnóstico etiológico. Un diagnóstico virológico oportuno repercute directamente en un mejor manejo del paciente y en la disminución del uso innecesario de antibióticos. . Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2021-10-12 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion texto texto texto https://revistas.unc.edu.ar/index.php/med/article/view/35099 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 78 No. Suplemento (2021): Suplemento JIC XXII Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 78 Núm. Suplemento (2021): Suplemento JIC XXII Revista da Faculdade de Ciências Médicas de Córdoba; v. 78 n. Suplemento (2021): Suplemento JIC XXII 1853-0605 0014-6722 http://creativecommons.org/licenses/by-nc/4.0 |