Cardiovascular risk and subclinical atherosclerosis in a psoriatic arthritis cohort
Abstract: INTRODUCTION: Psoriatic arthritis (PsA) is a chronic and inflammatory disease associated with higher cardiovascular morbidity and mortality compared to the general population. Currently, it is considered an independent risk factor for cardiovascular (CV) diseases. OBJECTIVE: To e...
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2021
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/35074 |
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I10-R327-article-35074 |
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Universidad Nacional de Córdoba |
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I-10 |
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R-327 |
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Revista de la Facultad de Ciencias Médicas de Córdoba |
| format |
Artículo revista |
| topic |
Psoriatic arthritis Cardiovascular risk Artritis Psoriasica Riesgo Cardiovascular Morbimortalidad Cardiovascular |
| spellingShingle |
Psoriatic arthritis Cardiovascular risk Artritis Psoriasica Riesgo Cardiovascular Morbimortalidad Cardiovascular Quaglia , MI Figueroa , RM Gobbi , C Albiero , JA Castrillon , ME Lewis , D Alba , P Savio , V Cardiovascular risk and subclinical atherosclerosis in a psoriatic arthritis cohort |
| topic_facet |
Psoriatic arthritis Cardiovascular risk Artritis Psoriasica Riesgo Cardiovascular Morbimortalidad Cardiovascular |
| author |
Quaglia , MI Figueroa , RM Gobbi , C Albiero , JA Castrillon , ME Lewis , D Alba , P Savio , V |
| author_facet |
Quaglia , MI Figueroa , RM Gobbi , C Albiero , JA Castrillon , ME Lewis , D Alba , P Savio , V |
| author_sort |
Quaglia , MI |
| title |
Cardiovascular risk and subclinical atherosclerosis in a psoriatic arthritis cohort |
| title_short |
Cardiovascular risk and subclinical atherosclerosis in a psoriatic arthritis cohort |
| title_full |
Cardiovascular risk and subclinical atherosclerosis in a psoriatic arthritis cohort |
| title_fullStr |
Cardiovascular risk and subclinical atherosclerosis in a psoriatic arthritis cohort |
| title_full_unstemmed |
Cardiovascular risk and subclinical atherosclerosis in a psoriatic arthritis cohort |
| title_sort |
cardiovascular risk and subclinical atherosclerosis in a psoriatic arthritis cohort |
| description |
Abstract:
INTRODUCTION: Psoriatic arthritis (PsA) is a chronic and inflammatory disease associated with higher cardiovascular morbidity and mortality compared to the general population. Currently, it is considered an independent risk factor for cardiovascular (CV) diseases.
OBJECTIVE: To evaluate the cardiovascular risk profile and the presence of subclinical atherosclerosis in patients with PsA.
MATERIAL AND METHODS: A cross-sectional study was performed between July / 2019-2020. Patients with PsA were included according to Caspar criteria. Demographic data, comorbidities, duration of the disease and involved domains were analyzed. Disease activity was evaluated by PASI, BSA and DAPSA, considering remission by DAPSA and MDA. CV risk was stratified according to SCORE. Subclinical atherosclerosis (ATEsc) and it was defined by carotid ultrasound, with the presence of myointimal thickening and atherosclerotic plaque. Patients with a previous cardiovascular event were excluded. Continuous variables analyzed were median and interquartile ranges, and categorical as frequency and percentage.
RESULTS: 42 patients were included. The median age was 54.50 years (41.75-60.75), with 60% of women. 48% of patients were obese, 36% hypertensive, 31% Hyperlipidemia, 24% diabetic, and 19% smokers. The median duration of psoriasis was 16 years (6.75-23.75), while APs was 12 months (12-72). 83% (34) had polyarticular peripheral involvement, 26% (11) axial, 63% (26) nail, 31% (13) dactylitis and 26% (11) enthesitis. 28% (11/40) of the patients presented MDA and 8% (3/40) remission. 80.5% (33/41) presented moderate CV risk and 19.5% (8/41) high-very high. 31.5% (38/42) of the patients had ATEsc. The group with high CV risk was significantly associated with the presence of ATEsc (p = 0.01). We not found a relationship between ATEsc and the absence of classic CV risk factors, involved domains, or disease activity.
CONCLUSION: In our study, we found a high risk for the cardiovascular events with the presence of subclinical atherosclerosis in one third of the patients. The evaluation of cardiovascular risk and management of comorbidities in individuals with PsA is essential |
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2021 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/35074 |
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I10-R327-article-350742024-04-15T16:19:09Z Cardiovascular risk and subclinical atherosclerosis in a psoriatic arthritis cohort Riesgo cardiovascular y aterosclerosis subclínica en una cohorte de artritis psoriásica Quaglia , MI Figueroa , RM Gobbi , C Albiero , JA Castrillon , ME Lewis , D Alba , P Savio , V Psoriatic arthritis Cardiovascular risk Artritis Psoriasica Riesgo Cardiovascular Morbimortalidad Cardiovascular Abstract: INTRODUCTION: Psoriatic arthritis (PsA) is a chronic and inflammatory disease associated with higher cardiovascular morbidity and mortality compared to the general population. Currently, it is considered an independent risk factor for cardiovascular (CV) diseases. OBJECTIVE: To evaluate the cardiovascular risk profile and the presence of subclinical atherosclerosis in patients with PsA. MATERIAL AND METHODS: A cross-sectional study was performed between July / 2019-2020. Patients with PsA were included according to Caspar criteria. Demographic data, comorbidities, duration of the disease and involved domains were analyzed. Disease activity was evaluated by PASI, BSA and DAPSA, considering remission by DAPSA and MDA. CV risk was stratified according to SCORE. Subclinical atherosclerosis (ATEsc) and it was defined by carotid ultrasound, with the presence of myointimal thickening and atherosclerotic plaque. Patients with a previous cardiovascular event were excluded. Continuous variables analyzed were median and interquartile ranges, and categorical as frequency and percentage. RESULTS: 42 patients were included. The median age was 54.50 years (41.75-60.75), with 60% of women. 48% of patients were obese, 36% hypertensive, 31% Hyperlipidemia, 24% diabetic, and 19% smokers. The median duration of psoriasis was 16 years (6.75-23.75), while APs was 12 months (12-72). 83% (34) had polyarticular peripheral involvement, 26% (11) axial, 63% (26) nail, 31% (13) dactylitis and 26% (11) enthesitis. 28% (11/40) of the patients presented MDA and 8% (3/40) remission. 80.5% (33/41) presented moderate CV risk and 19.5% (8/41) high-very high. 31.5% (38/42) of the patients had ATEsc. The group with high CV risk was significantly associated with the presence of ATEsc (p = 0.01). We not found a relationship between ATEsc and the absence of classic CV risk factors, involved domains, or disease activity. CONCLUSION: In our study, we found a high risk for the cardiovascular events with the presence of subclinical atherosclerosis in one third of the patients. The evaluation of cardiovascular risk and management of comorbidities in individuals with PsA is essential Resumen: INTRODUCCIÓN: La artritis psoriásica (APs) es una enfermedad crónica e inflamatoria, asociada a una mayor morbimortalidad cardiovascular comparada con la población general. Actualmente, es considerada un factor de riesgo independiente para padecer enfermedades cardiovasculares (CV). OBJETIVO: Evaluar el perfil de riesgo cardiovascular y la presencia de aterosclerosis subclínica en pacientes con APs. MATERIAL Y MÉTODOS: Se realizó un estudio transversal entre Julio/2019-2020. Ingresaron pacientes con APs según criterios de Caspar. Se analizaron variables demográficas, comorbilidades, tiempo de evolución y dominios afectados. La actividad de la enfermedad se evaluó por PASI, BSA y DAPSA, considerando remisión por DAPSA y MDA. El riesgo CV fue estratificado según SCORE. Se definió aterosclerosis subclínica (ATEsc) mediante ecografía carotídea, con la presencia de engrosamiento miointimal y de placa aterosesclerótica. Se excluyeron pacientes con evento cardiovascular previo. Las variables continuas se expresaron como mediana y rangos intercuartílicos, las categóricas como frecuencia y porcentaje. RESULTADOS: Se incluyeron 42 pacientes. Presentaron una mediana de 54.50 años(41.75-60.75), siendo el 60% mujeres. 48% eran obesos, 36% hipertensos, 31% dislipémicos, 24% diabéticos y 19% tabaquistas. La mediana de duración de la psoriasis fue 16 años (6.75-23.75), mientras que de APs 12 meses (12-72). El 83%(34) presentó compromiso periférico poliarticular, 26%(11) axial, 63%(26) ungueal, 31%(13) dactilitis y 26%(11) entesitis. El 28 %(11/40) de los pacientes presentaron MDA y el 8%(3/40) remisión. El 80.5%(33/41) presentó riesgo CV moderado y 19.5%(8/41) alto-muy alto. El 31,5% (38/42) de los pacientes evidenció ATEsc. Se relacionó significativamente al grupo que presentaba alto riesgo CV con la presencia de ATEsc (p= 0.01). No encontramos relación entre ATEsc y ausencia de factores de riesgo CV clásicos, dominios afectados ni actividad de la enfermedad. CONCLUSIÓN: En nuestra cohorte, encontramos un alto riesgo de padecer muerte de causa cardiovascular junto a la presencia de aterosclerosis subclínica en un tercio de los pacientes. Es fundamental la evaluación del riesgo cardiovascular y manejo de las comorbilidades en los individuos que presentan APs. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2021-10-12 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion texto texto texto https://revistas.unc.edu.ar/index.php/med/article/view/35074 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 78 No. Suplemento (2021): Suplemento JIC XXII Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 78 Núm. Suplemento (2021): Suplemento JIC XXII Revista da Faculdade de Ciências Médicas de Córdoba; v. 78 n. Suplemento (2021): Suplemento JIC XXII 1853-0605 0014-6722 http://creativecommons.org/licenses/by-nc/4.0 |