Daily intake of different types of fatty acids associated with dietary patterns and their relationship with the TP53-codon 72 polymorphism and the risk of oral squamous cell carcinoma
Abstract: Current evidence on diet-cancer interaction remains incomplete, particularly in oral carcinoma (OC). This study aimed to evaluate the relationship among daily saturated, monounsaturated and polyunsaturated fatty acids (FAs) intake and eating patterns in people with / without...
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2021
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/35073 |
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I10-R327-article-35073 |
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ojs |
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Universidad Nacional de Córdoba |
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I-10 |
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R-327 |
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Revista de la Facultad de Ciencias Médicas de Córdoba |
| format |
Artículo revista |
| topic |
oral cancer diet fatty acids Tp53 oral cancer diet fatty acids Tp53 . |
| spellingShingle |
oral cancer diet fatty acids Tp53 oral cancer diet fatty acids Tp53 . Don , J Aballay , L Pasqualini , ME Secchi , D Daily intake of different types of fatty acids associated with dietary patterns and their relationship with the TP53-codon 72 polymorphism and the risk of oral squamous cell carcinoma |
| topic_facet |
oral cancer diet fatty acids Tp53 oral cancer diet fatty acids Tp53 . |
| author |
Don , J Aballay , L Pasqualini , ME Secchi , D |
| author_facet |
Don , J Aballay , L Pasqualini , ME Secchi , D |
| author_sort |
Don , J |
| title |
Daily intake of different types of fatty acids associated with dietary patterns and their relationship with the TP53-codon 72 polymorphism and the risk of oral squamous cell carcinoma |
| title_short |
Daily intake of different types of fatty acids associated with dietary patterns and their relationship with the TP53-codon 72 polymorphism and the risk of oral squamous cell carcinoma |
| title_full |
Daily intake of different types of fatty acids associated with dietary patterns and their relationship with the TP53-codon 72 polymorphism and the risk of oral squamous cell carcinoma |
| title_fullStr |
Daily intake of different types of fatty acids associated with dietary patterns and their relationship with the TP53-codon 72 polymorphism and the risk of oral squamous cell carcinoma |
| title_full_unstemmed |
Daily intake of different types of fatty acids associated with dietary patterns and their relationship with the TP53-codon 72 polymorphism and the risk of oral squamous cell carcinoma |
| title_sort |
daily intake of different types of fatty acids associated with dietary patterns and their relationship with the tp53-codon 72 polymorphism and the risk of oral squamous cell carcinoma |
| description |
Abstract:
Current evidence on diet-cancer interaction remains incomplete, particularly in oral carcinoma (OC). This study aimed to evaluate the relationship among daily saturated, monounsaturated and polyunsaturated fatty acids (FAs) intake and eating patterns in people with / without OC, during a minimum period of five years, and its possible relationship with SNP TP53-R72P. A retrospective case-control study (n = 79), matched by sex and age (21-85 years old), was carried out. Dietary information was collected using a quantitative food frequency survey validated for Cordoba population. TP53-R72P alleles were determined using conventional PCR. The Mann–Whitney U test and logistic regression were applied to assess the association between case/control status and FAs intake adjusted by alcohol/tobacco, respectively. Dietary patterns were identified by principal component factor analysis. The intake of saturated FAs such as myristic (p = 0.037), palmitic (p = 0.004), stearic (p = 0.009), arachidic (p = 0.012), monounsaturated such as palmitoleic (p = 0.013), oleic (p = 0.002) and polyunsaturated as linoleic (p = 0.0006) and alpha-linoleic (p = 0.003) was higher in cases.
Omega6/omega3 ratio was significantly higher in cases (p = 0.003). The mutated C allele was more frequent in cases (p = 0.0061) than controls. All surveyed patients with OC were heterozygous for TP53-R72. In addition, they presented a high consumption of total fats in relation to controls.
The studied population presented a dietary pattern described as “Western diet”; related with a high daily intake of meat, eggs and alcohol; it was remarkable an association between red meat consumption and the presence of OC (p = 0.015). This diet has a high amount of omega-6 FAs, which leads to an increase in arachidonic acid and its derivatives, than have been related to the risk of OC. The presence of mutated TP53-R72P allele in OC patients is related to the loss of ability to induce apoptosis. The presence of both risk factors, diet and presence of a mutated polymorphic variant, could linked to an increaserisk of developing OC.
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| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2021 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/35073 |
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I10-R327-article-350732024-04-15T16:19:09Z Daily intake of different types of fatty acids associated with dietary patterns and their relationship with the TP53-codon 72 polymorphism and the risk of oral squamous cell carcinoma Ingesta de diferentes ácidos grasos dietarios asociados a patrones alimentarios y su relación con el polimorfismo de TP53-codon 72 y el riesgo de carcinoma oral de células escamosas. A Don , J Aballay , L Pasqualini , ME Secchi , D oral cancer diet fatty acids Tp53 oral cancer diet fatty acids Tp53 . Abstract: Current evidence on diet-cancer interaction remains incomplete, particularly in oral carcinoma (OC). This study aimed to evaluate the relationship among daily saturated, monounsaturated and polyunsaturated fatty acids (FAs) intake and eating patterns in people with / without OC, during a minimum period of five years, and its possible relationship with SNP TP53-R72P. A retrospective case-control study (n = 79), matched by sex and age (21-85 years old), was carried out. Dietary information was collected using a quantitative food frequency survey validated for Cordoba population. TP53-R72P alleles were determined using conventional PCR. The Mann–Whitney U test and logistic regression were applied to assess the association between case/control status and FAs intake adjusted by alcohol/tobacco, respectively. Dietary patterns were identified by principal component factor analysis. The intake of saturated FAs such as myristic (p = 0.037), palmitic (p = 0.004), stearic (p = 0.009), arachidic (p = 0.012), monounsaturated such as palmitoleic (p = 0.013), oleic (p = 0.002) and polyunsaturated as linoleic (p = 0.0006) and alpha-linoleic (p = 0.003) was higher in cases. Omega6/omega3 ratio was significantly higher in cases (p = 0.003). The mutated C allele was more frequent in cases (p = 0.0061) than controls. All surveyed patients with OC were heterozygous for TP53-R72. In addition, they presented a high consumption of total fats in relation to controls. The studied population presented a dietary pattern described as “Western diet”; related with a high daily intake of meat, eggs and alcohol; it was remarkable an association between red meat consumption and the presence of OC (p = 0.015). This diet has a high amount of omega-6 FAs, which leads to an increase in arachidonic acid and its derivatives, than have been related to the risk of OC. The presence of mutated TP53-R72P allele in OC patients is related to the loss of ability to induce apoptosis. The presence of both risk factors, diet and presence of a mutated polymorphic variant, could linked to an increaserisk of developing OC. Resumen: La evidencia actual sobre la interacción dieta-cáncer sigue siendo incompleta, particularmente en el carcinoma oral (CO). El objetivo del estudio fue evaluar la relación entre la ingesta dietaria de ácidos grasos (AGs) saturados, monoinsaturados y poliinsaturados y patrones de alimentación en personas con/sin CO, durante un período mínimo previo de cinco años al momento de la encuesta; y su posible relación con la presencia del polimorfismo TP53-R72P. Se realizó un estudio retrospectivo de casos/controles (n=79), apareados por sexo y edad (21-85 años). Se recolectaron datos de un cuestionario cuantitativo de frecuencia alimentaria validado para la población cordobesa. TP53-R72P se genotipificó por PCR alelo específica. Se aplicaron la prueba Mann-Whitney y regresión logística para evaluar la asociación entre casos/controles y la ingesta de AGs ajustada por alcohol/tabaco, respectivamente. Los patrones alimentarios se identificaron por análisis factorial de componentes principales. La ingesta de AGs saturados como mirístico (p=0.037), palmítico (p=0.004), esteárico (p=0.009), araquídico (p=0.012), monoinsaturados como palmitoleico (p=0.013), oleico (p=0.002) y poliinsaturados como linoleico (p=0.0006) y alfa-linoleico (p=0.003) fue mayor en los casos. La relación omega-6/omega-3 fue significativamente mayor en los casos (p=0.003). De los sujetos genotipificados, el alelo mutado C fue más frecuente en los casos (p=0.0061) que en los controles. De los sujetos encuestados y con genotipificación TP53-R72P se observó que todos los pacientes con CO eran heterocigotos y, además, presentaron un alto consumo de grasas en relación a los controles. La población total presentó un patrón alimentario reconocido como dieta occidental asociada a una ingesta diaria elevada en carnes, huevos y alcohol de la población estudiada; siendo notorio una asociación entre el consumo de carnes rojas y la presencia de CO (p=0.015). Esta dieta presenta una alta cantidad de AGs omega-6, lo que conduce a un aumento del ácido araquidónico y sus derivados, los cuales se han relacionado con el riesgo de CO. La presencia del alelo mutado TP53-R72P en pacientes con CO está relacionado con la pérdida de capacidad de conducir a la célula a apoptosis. La presencia de ambos factores de riesgo, dieta y presencia de variante polimórfica mutada, podría incrementar el riesgo de desarrollar CO. . Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2021-10-12 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion texto texto texto https://revistas.unc.edu.ar/index.php/med/article/view/35073 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 78 No. Suplemento (2021): Suplemento JIC XXII Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 78 Núm. Suplemento (2021): Suplemento JIC XXII Revista da Faculdade de Ciências Médicas de Córdoba; v. 78 n. Suplemento (2021): Suplemento JIC XXII 1853-0605 0014-6722 http://creativecommons.org/licenses/by-nc/4.0 |