Overexpression of the Her-1 oncogene and its relationship with macroscopic prognostic tumor variables in invasive cervical cancer
Abstract: Cervical cancer is the leading cause of death in women of reproductive age in developing countries. The treatment of advanced stages is frequently unsatisfactory. Overexpression of the epidermal growth factor receptor (EGFR or Her1) could play a significant role in signaling both...
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| Formato: | Artículo revista |
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2021
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/35008 |
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I10-R327-article-35008 |
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Universidad Nacional de Córdoba |
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I-10 |
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R-327 |
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Revista de la Facultad de Ciencias Médicas de Córdoba |
| format |
Artículo revista |
| topic |
Uterine Cervical Cancer Epidermal Growth Factor Receptor Prognosis cáncer de cuello uterino Receptores del Factor de Crecimiento Epidérmico Pronóstico |
| spellingShingle |
Uterine Cervical Cancer Epidermal Growth Factor Receptor Prognosis cáncer de cuello uterino Receptores del Factor de Crecimiento Epidérmico Pronóstico Franco , GF Moya , MP Calafat , P Medina , A Dionisio de Cabalier , ME Kasparian, AC Overexpression of the Her-1 oncogene and its relationship with macroscopic prognostic tumor variables in invasive cervical cancer |
| topic_facet |
Uterine Cervical Cancer Epidermal Growth Factor Receptor Prognosis cáncer de cuello uterino Receptores del Factor de Crecimiento Epidérmico Pronóstico |
| author |
Franco , GF Moya , MP Calafat , P Medina , A Dionisio de Cabalier , ME Kasparian, AC |
| author_facet |
Franco , GF Moya , MP Calafat , P Medina , A Dionisio de Cabalier , ME Kasparian, AC |
| author_sort |
Franco , GF |
| title |
Overexpression of the Her-1 oncogene and its relationship with macroscopic prognostic tumor variables in invasive cervical cancer |
| title_short |
Overexpression of the Her-1 oncogene and its relationship with macroscopic prognostic tumor variables in invasive cervical cancer |
| title_full |
Overexpression of the Her-1 oncogene and its relationship with macroscopic prognostic tumor variables in invasive cervical cancer |
| title_fullStr |
Overexpression of the Her-1 oncogene and its relationship with macroscopic prognostic tumor variables in invasive cervical cancer |
| title_full_unstemmed |
Overexpression of the Her-1 oncogene and its relationship with macroscopic prognostic tumor variables in invasive cervical cancer |
| title_sort |
overexpression of the her-1 oncogene and its relationship with macroscopic prognostic tumor variables in invasive cervical cancer |
| description |
Abstract:
Cervical cancer is the leading cause of death in women of reproductive age in developing countries. The treatment of advanced stages is frequently unsatisfactory. Overexpression of the epidermal growth factor receptor (EGFR or Her1) could play a significant role in signaling both tumor genesis and growth. It’s not clearly defined yet its clinical and therapeutic utility or whether it constitutes a predictor of poor prognosis. Therefore, it is of interest to investigate new histoprognostic factors associated with its overexpression.
Retrospective Cohort Study. Samples of tumor tissues were studied from thirty patients who attended the Hospital Nacional de Clínicas, and nine from the Sanatorio Allende, both in Córdoba city. The diagnosis was invasive cervical cancer (epidermal vs. adenocarcinoma?) treated with radical Wertheim Meiggs hysterectomy or radical abdominal trachelectomy. EGFR pharmDx ™ Kit for EGFR (HER1) diagnostic assay was used to determine the overexpression of HER1 on tumoral tissue. Total absence of staining was considered a negative result. Any intensity of cell membrane staining was considered positive, with increasing values from +1 to +3. The following variables were analyzed: tumor stage and size at diagnosis, myocervical involvement, parametrial involvement, and vaginal vault involvement. Student's t test was used for comparison of data. A p-value < 0.05 was considered statistically significant.
On the macroscopic examination: 15 ulcerated, 12 vegetant, 4 infiltrative y 8 combined. Microscopic findings: 2 adenocarcinomas, 1 adenosquamous and 36 squamous cell carcinomas. The higher intensity of HER1 marking was correlated with a larger tumor size at the time of diagnosis (p = 0.012), presentation of the disease in advanced stages, and greater penetration of the tumor into the myocervix (p = 0.032). No significant differences were found in parametrial or vaginal vault involvement.
The overexpression of HER1 would constitute a factor of poor prognosis of the disease that would show a more aggressive behavior of the primary tumor, with faster growth of the lesion, especially at higher intensities of staining. It constitutes a factor whose usefulness in practice should be weighed in subsequent studies to help define new therapeutic strategies: adjuvant chemotherapy, postoperative radiotherapy and / or concurrent chemotherapy. |
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2021 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/35008 |
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I10-R327-article-350082024-04-15T16:19:09Z Overexpression of the Her-1 oncogene and its relationship with macroscopic prognostic tumor variables in invasive cervical cancer Sobreexpresión del oncogen Her-1 y su relación con variables macroscópicas tumorales de pronóstico en cáncer invasor de cuello uterino Franco , GF Moya , MP Calafat , P Medina , A Dionisio de Cabalier , ME Kasparian, AC Uterine Cervical Cancer Epidermal Growth Factor Receptor Prognosis cáncer de cuello uterino Receptores del Factor de Crecimiento Epidérmico Pronóstico Abstract: Cervical cancer is the leading cause of death in women of reproductive age in developing countries. The treatment of advanced stages is frequently unsatisfactory. Overexpression of the epidermal growth factor receptor (EGFR or Her1) could play a significant role in signaling both tumor genesis and growth. It’s not clearly defined yet its clinical and therapeutic utility or whether it constitutes a predictor of poor prognosis. Therefore, it is of interest to investigate new histoprognostic factors associated with its overexpression. Retrospective Cohort Study. Samples of tumor tissues were studied from thirty patients who attended the Hospital Nacional de Clínicas, and nine from the Sanatorio Allende, both in Córdoba city. The diagnosis was invasive cervical cancer (epidermal vs. adenocarcinoma?) treated with radical Wertheim Meiggs hysterectomy or radical abdominal trachelectomy. EGFR pharmDx ™ Kit for EGFR (HER1) diagnostic assay was used to determine the overexpression of HER1 on tumoral tissue. Total absence of staining was considered a negative result. Any intensity of cell membrane staining was considered positive, with increasing values from +1 to +3. The following variables were analyzed: tumor stage and size at diagnosis, myocervical involvement, parametrial involvement, and vaginal vault involvement. Student's t test was used for comparison of data. A p-value < 0.05 was considered statistically significant. On the macroscopic examination: 15 ulcerated, 12 vegetant, 4 infiltrative y 8 combined. Microscopic findings: 2 adenocarcinomas, 1 adenosquamous and 36 squamous cell carcinomas. The higher intensity of HER1 marking was correlated with a larger tumor size at the time of diagnosis (p = 0.012), presentation of the disease in advanced stages, and greater penetration of the tumor into the myocervix (p = 0.032). No significant differences were found in parametrial or vaginal vault involvement. The overexpression of HER1 would constitute a factor of poor prognosis of the disease that would show a more aggressive behavior of the primary tumor, with faster growth of the lesion, especially at higher intensities of staining. It constitutes a factor whose usefulness in practice should be weighed in subsequent studies to help define new therapeutic strategies: adjuvant chemotherapy, postoperative radiotherapy and / or concurrent chemotherapy. Resumen: El cáncer de cuello uterino es la principal causa de muerte en mujeres en edad reproductiva en países en vías de desarrollo. Su tratamiento en estadios avanzados es frecuentemente insatisfactorio. La sobreexpresión del receptor del factor de crecimiento epidérmico (EGFR o Her1) podría tener un rol significativo en la señalización de la génesis y el crecimiento tumoral. No está definida claramente su utilidad clínica y terapéutica o si constituye un factor predictor de mal pronóstico. Resulta de interés investigar nuevos factores pronósticos tumorales asociados con su sobrexpresión. Estudio Retrospectivo de Cohorte. Se estudiaron muestras de los tejidos tumorales y de treinta pacientes atendidas en el Hospital Nacional de Clínicas y nueve del Sanatorio Allende de la ciudad de Córdoba, cuyo diagnóstico fue cáncer invasor de cuello uterino, tratadas con cirugía. Para determinar la sobreexpresión del HER1 en el material tumoral se utilizó el ensayo diagnóstico EGFR pharmDx™ Kit para EGFR (HER1). La ausencia de tinción se consideró negativa. Cualquier intensidad de tinción de la membrana celular fue considerada positiva, con valores crecientes de +1 a +3. Se analizaron las siguientes variables: estadio y tamaño tumoral al momento del diagnóstico, compromiso miocervical, compromiso de parametrios y compromiso de la cúpula vaginal. El análisis de las variables numéricas se realizó con el test t de Student. Valores de p < 0.05 fueron considerados estadísticamente significativos. Al examen macroscópico: 15 ulcerados, 12 vegetantes, 4 infiltrantes y 8 mixtos. A la microscopia: 2 adenocarcinomas, 1 adenoescamoso y 36 epidermoides. La mayor intensidad de marcación HER1 se correlacionó con un mayor tamaño tumoral al momento del diagnóstico (p=0.012), presentación de la enfermedad en estadios avanzados y mayor penetración del tumor en el miocervix (p=0.032). No se encontraron diferencias significativas en el compromiso parametrial ni de la cúpula vaginal. La sobrexpresión del HER1 constituiría un factor de mal pronóstico que pondría en evidenca mayor agresividad del tumor primario y crecimiento más rápido de la lesión, a mayores intensidades de tinción. Constituye un factor cuya utilidad en la práctica debería ser ponderada en estudios posteriores para definir nuevas estrategias terapéuticas: adyuvancia, radioterapia postoperatoria y/o quimioterapia concurrente. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2021-10-12 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion texto texto texto https://revistas.unc.edu.ar/index.php/med/article/view/35008 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 78 No. Suplemento (2021): Suplemento JIC XXII Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 78 Núm. Suplemento (2021): Suplemento JIC XXII Revista da Faculdade de Ciências Médicas de Córdoba; v. 78 n. Suplemento (2021): Suplemento JIC XXII 1853-0605 0014-6722 http://creativecommons.org/licenses/by-nc/4.0 |